Simon Christopher Body, MBChB, MPH, FAHA
Professor, Anesthesiology
Biography
Dr. Body completed his residency and fellowship training in New Zealand. After nearly 30 years of experience at Brigham and Women’s and Beth Israel Hospitals, Dr. Body joined BU School of Medicine in 2020. His clinical expertise is in adult cardiac and thoracic anesthesia.
In 2000, Dr. Body initiated and led a program of examining the genetic influences upon adverse clinical outcomes after coronary artery bypass graft (CABG) surgery. Along with his co-investigators at BWH (Dr. J. Daniel Muehlschlegel), he collected over 2200 patients who had undergone primary CABG as the substrate for this research. Dr. Body and his colleagues are examining the role of variation in candidate genes and their phenotypic expression on adverse postoperative outcomes, specifically atrial fibrillation.
The other major focus of Dr. Body’s research is the genetic causes of bicuspid aortic valve (BAV) disease and its and its consequences – calcific aortic valve disease and aortic aneurysm. Along with his colleagues at US, Canadian and European institutions he has led the International BAV Consortium which has collected over 2,500 patients with a bicuspid aortic valve. His own cohort has over 1,700 BAV patients. These cohorts along with those of the GenTAC program and others from collaborating Investigators are currently being used to determine these genetic causes of BAV. Dr. Body is a member of the GenTAC Alliance and Vice Chair of its Basic Science Working Group.
Dr. Body has published more 220 papers, several book chapter and has been almost continuously funded by the NIH, AHA and other organizations since 2001. He has extensive experience mentoring clinical and research residents, fellows and staff.
Publications
- Published on 8/1/2023
Tessler I, Albuisson J, Piñeiro-Sabarís R, Verstraeten A, Kamber Kaya HE, Siguero-Álvarez M, Goudot G, MacGrogan D, Luyckx I, Shpitzen S, Levin G, Kelman G, Reshef N, Mananet H, Holdcraft J, Muehlschlegel JD, Peloso GM, Oppenheim O, Cheng C, Mazzella JM, Andelfinger G, Mital S, Eriksson P, Billon C, Heydarpour M, Dietz HC, Jeunemaitre X, Leitersdorf E, Sprinzak D, Blacklow SC, Body SC, Carmi S, Loeys B, de la Pompa JL, Gilon D, Messas E, Durst R. Novel Association of the NOTCH Pathway Regulator MIB1 Gene With the Development of Bicuspid Aortic Valve. JAMA Cardiol. 2023 Aug 01; 8(8):721-731. PMID: 37405741.
Read at: PubMed - Published on 7/10/2023
Blaser MC, Buffolo F, Halu A, Turner ME, Schlotter F, Higashi H, Pantano L, Clift CL, Saddic LA, Atkins SK, Rogers MA, Pham T, Vromman A, Shvartz E, Sukhova GK, Monticone S, Camussi G, Robson SC, Body SC, Muehlschlegel JD, Singh SA, Aikawa M, Aikawa E. Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis. Circulation. 2023 Aug 22; 148(8):661-678. PMID: 37427430.
Read at: PubMed - Published on 3/7/2023
Iqbal F, Schlotter F, Becker-Greene D, Lupieri A, Goettsch C, Hutcheson JD, Rogers MA, Itoh S, Halu A, Lee LH, Blaser MC, Mlynarchik AK, Hagita S, Kuraoka S, Chen HY, Engert JC, Passos LSA, Jha PK, Osborn EA, Jaffer FA, Body SC, Robson SC, Thanassoulis G, Aikawa M, Singh SA, Sonawane AR, Aikawa E. Sortilin enhances fibrosis and calcification in aortic valve disease by inducing interstitial cell heterogeneity. Eur Heart J. 2023 Mar 07; 44(10):885-898. PMID: 36660854.
Read at: PubMed - Published on 9/7/2022
Kelly I, Fields K, Sarin P, Pang A, Sigurdsson MI, Shernan SK, Fox AA, Body SC, Muehlschlegel JD. Identifying Patients Vulnerable to Inadequate Pain Resolution After Cardiac Surgery. Semin Thorac Cardiovasc Surg. 2022 Sep 07. PMID: 36084862.
Read at: PubMed - Published on 5/1/2022
Roselli C, Yu M, Nauffal V, Georges A, Yang Q, Love K, Weng LC, Delling FN, Maurya SR, Schrölkamp M, Tfelt-Hansen J, Hagège A, Jeunemaitre X, Debette S, Amouyel P, Guan W, Muehlschlegel JD, Body SC, Shah S, Samad Z, Kyryachenko S, Haynes C, Rienstra M, Le Tourneau T, Probst V, Roussel R, Wijdh-Den Hamer IJ, Siland JE, Knowlton KU, Jacques Schott J, Levine RA, Benjamin EJ, Vasan RS, Horne BD, Muhlestein JB, Benfari G, Enriquez-Sarano M, Natale A, Mohanty S, Trivedi C, Shoemaker MB, Yoneda ZT, Wells QS, Baker MT, Farber-Eger E, Michelena HI, Lundby A, Norris RA, Slaugenhaupt SA, Dina C, Lubitz SA, Bouatia-Naji N, Ellinor PT, Milan DJ. Genome-wide association study reveals novel genetic loci: a new polygenic risk score for mitral valve prolapse. Eur Heart J. 2022 May 01; 43(17):1668-1680. PMID: 35245370.
Read at: PubMed - Published on 4/12/2022
Decano JL, Iwamoto Y, Goto S, Lee JY, Matamalas JT, Halu A, Blaser M, Lee LH, Pieper B, Chelvanambi S, Silva-Nicolau J, Bartoli-Leonard F, Higashi H, Shibata H, Vyas P, Wang J, Gostjeva E, Body SC, Singh SA, Aikawa M, Aikawa E. A disease-driver population within interstitial cells of human calcific aortic valves identified via single-cell and proteomic profiling. Cell Rep. 2022 Apr 12; 39(2):110685. PMID: 35417712.
Read at: PubMed - Published on 10/20/2021
Ward Z, Schmeier S, Saddic L, Sigurdsson MI, Cameron VA, Pearson J, Miller A, Morley-Bunker A, Gorham J, Seidman JG, Moravec CS, Sweet WE, Aranki SF, Body S, Muehlschlegel JD, Pilbrow AP. Novel and Annotated Long Noncoding RNAs Associated with Ischemia in the Human Heart. Int J Mol Sci. 2021 Oct 20; 22(21). PMID: 34768754.
Read at: PubMed - Published on 6/22/2021
Hutcheson JD, Schlotter F, Creager MD, Li X, Pham T, Vyas P, Higashi H, Body SC, Aikawa M, Singh SA, Kos L, Aikawa E. Elastogenesis Correlates With Pigment Production in Murine Aortic Valve Leaflets. Front Cardiovasc Med. 2021; 8:678401. PMID: 34239903.
Read at: PubMed - Published on 4/16/2021
Monda E, Fusco A, Della Corte A, Caiazza M, Cirillo A, Gragnano F, Giugliano MP, Citro R, Rubino M, Esposito A, Cesaro A, Di Fraia F, Palmiero G, Di Maio M, Monda M, Calabrò P, Frisso G, Nistri S, Bossone E, Body SC, Russo MG, Limongelli G. Impact of Regular Physical Activity on Aortic Diameter Progression in Paediatric Patients with Bicuspid Aortic Valve. Pediatr Cardiol. 2021 Jun; 42(5):1133-1140. PMID: 33864103.
Read at: PubMed - Published on 1/6/2021
Schlotter F, de Freitas RCC, Rogers MA, Blaser MC, Wu PJ, Higashi H, Halu A, Iqbal F, Andraski AB, Rodia CN, Kuraoka S, Wen JR, Creager M, Pham T, Hutcheson JD, Body SC, Kohan AB, Sacks FM, Aikawa M, Singh SA, Aikawa E. ApoC-III is a novel inducer of calcification in human aortic valves. J Biol Chem. 2021 Jan-Jun; 296:100193. PMID: 33334888.
Read at: PubMed
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