Sachiko Homma Takayama, PhD, is a Research Assistant Professor of Neurology at the Chobanian and Avedisian School of Medicine. For her research, she has received funding from many organizations including Friends of FSH Research for researching the roles of molecular chaperones and the ubiquitin-proteasome system in skeletal muscle diseases. She has made new discoveries in the medical field including having identified a new pathway of myogenic cell death in myofibrillar myopathy.
- Otsuma Women's University, PhD
- University of Tsukuba, BS
- Published on 12/8/2022
Wang X, Chen J, Homma ST, Wang Y, Smith GR, Ruf-Zamojski F, Sealfon SC, Zhou L. Diverse effector and regulatory functions of fibro/adipogenic progenitors during skeletal muscle fibrosis in muscular dystrophy. iScience. 2023 Jan 20; 26(1):105775. PMID: 36594034.
- Published on 5/10/2022
Beermann ML, Homma S, Miller JB. Proximity ligation assay to detect DUX4 protein in FSHD1 muscle: a pilot study. BMC Res Notes. 2022 May 10; 15(1):163. PMID: 35538497.
- Published on 2/15/2022
Masteika IF, Sathya A, Homma S, Miller BM, Boyce FM, Miller JB. Downstream events initiated by expression of FSHD-associated DUX4: Studies of nucleocytoplasmic transport, ?H2AX accumulation, and Bax/Bak-dependence. Biol Open. 2022 02 15; 11(2). PMID: 35191484.
- Published on 2/19/2019
Mitsuhashi H, Homma S, Beermann ML, Ishimaru S, Takeda H, Yu BK, Liu K, Duraiswamy S, Boyce FM, Miller JB. Efficient system for upstream mRNA trans-splicing to generate covalent, head-to-tail, protein multimers. Sci Rep. 2019 02 19; 9(1):2274. PMID: 30783185.
- Published on 4/26/2018
Mitsuhashi H, Ishimaru S, Homma S, Yu B, Honma Y, Beermann ML, Miller JB. Functional domains of the FSHD-associated DUX4 protein. Biol Open. 2018 Apr 26; 7(4). PMID: 29618456.
- Published on 12/1/2016
Homma S, Beermann ML, Yu B, Boyce FM, Miller JB. Nuclear bodies reorganize during myogenesis in vitro and are differentially disrupted by expression of FSHD-associated DUX4. Skelet Muscle. 2016 Dec 01; 6(1):42. PMID: 27906075.
- Published on 3/29/2015
Jones TI, King OD, Himeda CL, Homma S, Chen JC, Beermann ML, Yan C, Emerson CP, Miller JB, Wagner KR, Jones PL. Individual epigenetic status of the pathogenic D4Z4 macrosatellite correlates with disease in facioscapulohumeral muscular dystrophy. Clin Epigenetics. 2015; 7(1):37. PMID: 25904990.
- Published on 1/15/2015
Homma S, Beermann ML, Boyce FM, Miller JB. Expression of FSHD-related DUX4-FL alters proteostasis and induces TDP-43 aggregation. Ann Clin Transl Neurol. 2015 Feb; 2(2):151-66. PMID: 25750920.
- Published on 3/17/2014
Himeda CL, Debarnot C, Homma S, Beermann ML, Miller JB, Jones PL, Jones TI. Myogenic enhancers regulate expression of the facioscapulohumeral muscular dystrophy-associated DUX4 gene. Mol Cell Biol. 2014 Jun; 34(11):1942-55. PMID: 24636994.
- Published on 7/13/2012
Jones TI, Chen JC, Rahimov F, Homma S, Arashiro P, Beermann ML, King OD, Miller JB, Kunkel LM, Emerson CP, Wagner KR, Jones PL. Facioscapulohumeral muscular dystrophy family studies of DUX4 expression: evidence for disease modifiers and a quantitative model of pathogenesis. Hum Mol Genet. 2012 Oct 15; 21(20):4419-30. PMID: 22798623.
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