Qiong L. Zhou, PhD
Research Assistant Professor, Pharmacology, Physiology & Biophysics
Biography
Dr. Zhou currently works directly with Zhen Y. Jiang, M.D., Ph.D., Director of the Laboratory of Diabetes and Obesity Research, on understanding how insulin signaling networks and innate immunity regulate metabolic functions.
During her research career, Qiong L. Zhou, Ph.D., has contributed significantly to collaborative projects with renowned scientists. In a collaborative study with Dr. Craig Mello’s laboratory while at the University of Massachusetts Medical School, she established microRNA profiles of three sets of samples from: 1. 3T3-L1 preadipocytes, adipocytes and adipocytes treated with insulin; 2. human muscle tissues from non exercised or exercised individuals; and 3. human monocytes before and after lipid perfusion by using deep sequencing technique. She is continuing to analyze these profiles to identify the major microRNAs that target the components of insulin signaling pathways and key molecules involved in diabetes and obesity. She was also part of the team that identified a new Akt substrate, TBC1D1, a RabGAP containing protein. These results were published in a paper suggesting that TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes (Zhou et al, Biochem J. 2008). While at the Sanford-Burnham Medical Research Institute, Qiong has worked on a project dissecting the role of neutrophil elastase in the development of high-fat diet induced obesity and related inflammation, insulin resistance and energy imbalance with different mouse models. This also resulted in a recent publication (Aubert et al, Cell Metabolism 2013).
Education
- King's College London, PhD
Publications
- Published on 3/29/2018
Zhou QL, Song Y, Huang CH, Huang JY, Gong Z, Liao Z, Sharma AG, Greene L, Deng JZ, Rigor MC, Xie X, Qi S, Ayala JE, Jiang ZY. Membrane Trafficking Protein CDP138 Regulates Fat Browning and Insulin Sensitivity through Controlling Catecholamine Release. Mol Cell Biol. 2018 04 15; 38(8). PMID: 29378832.
Read at: PubMed - Published on 2/15/2017
Huang JY, Zhou QL, Huang CH, Song Y, Sharma AG, Liao Z, Zhu K, Massidda MW, Jamieson RR, Zhang JY, Tenen DG, Jiang ZY. Neutrophil Elastase Regulates Emergency Myelopoiesis Preceding Systemic Inflammation in Diet-induced Obesity. J Biol Chem. 2017 Mar 24; 292(12):4770-4776. PMID: 28202548.
Read at: PubMed - Published on 4/2/2013
Mansuy-Aubert V, Zhou QL, Xie X, Gong Z, Huang JY, Khan AR, Aubert G, Candelaria K, Thomas S, Shin DJ, Booth S, Baig SM, Bilal A, Hwang D, Zhang H, Lovell-Badge R, Smith SR, Awan FR, Jiang ZY. Imbalance between neutrophil elastase and its inhibitor a1-antitrypsin in obesity alters insulin sensitivity, inflammation, and energy expenditure. Cell Metab. 2013 Apr 2; 17(4):534-48. PMID: 23562077.
Read at: PubMed - Published on 9/7/2011
Xie X, Gong Z, Mansuy-Aubert V, Zhou QL, Tatulian SA, Sehrt D, Gnad F, Brill LM, Motamedchaboki K, Chen Y, Czech MP, Mann M, Krüger M, Jiang ZY. C2 domain-containing phosphoprotein CDP138 regulates GLUT4 insertion into the plasma membrane. Cell Metab. 2011 Sep 7; 14(3):378-89. PMID: 21907143.
Read at: PubMed - Published on 6/28/2010
Zhou QL, Jiang ZY, Mabardy AS, Del Campo CM, Lambright DG, Holik J, Fogarty KE, Straubhaar J, Nicoloro S, Chawla A, Czech MP. A novel pleckstrin homology domain-containing protein enhances insulin-stimulated Akt phosphorylation and GLUT4 translocation in adipocytes. J Biol Chem. 2010 Sep 3; 285(36):27581-9. PMID: 20587420.
Read at: PubMed - Published on 2/26/2010
Walz HA, Shi X, Chouinard M, Bue CA, Navaroli DM, Hayakawa A, Zhou QL, Nadler J, Leonard DM, Corvera S. Isoform-specific regulation of Akt signaling by the endosomal protein WDFY2. J Biol Chem. 2010 May 7; 285(19):14101-8. PMID: 20189988.
Read at: PubMed - Published on 5/1/2008
Zhou QL, Jiang ZY, Holik J, Chawla A, Hagan GN, Leszyk J, Czech MP. Akt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes. Biochem J. 2008 May 1; 411(3):647-55. PMID: 18215134.
Read at: PubMed - Published on 10/2/2007
Forman SA, Zhou QL, Stewart DS. Photoactivated 3-azioctanol irreversibly desensitizes muscle nicotinic ACh receptors via interactions at alphaE262. Biochemistry. 2007 Oct 23; 46(42):11911-8. PMID: 17910479.
Read at: PubMed - Published on 3/30/2005
Jiang ZY, Zhou QL, Holik J, Patel S, Leszyk J, Coleman K, Chouinard M, Czech MP. Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells. J Biol Chem. 2005 Jun 3; 280(22):21622-8. PMID: 15799971.
Read at: PubMed - Published on 11/1/2004
Zhou QL, Park JG, Jiang ZY, Holik JJ, Mitra P, Semiz S, Guilherme A, Powelka AM, Tang X, Virbasius J, Czech MP. Analysis of insulin signalling by RNAi-based gene silencing. Biochem Soc Trans. 2004 Nov; 32(Pt 5):817-21. PMID: 15494023.
Read at: PubMed
View 6 more publications: View full profile at BUMC