Qiong L. Zhou, Ph.D.
Ph.D.: King’s College University of London, U.K.
Laboratory: Laboratory of Diabetes and Obesity Research
Dr. Zhou currently works directly with Zhen Y. Jiang, M.D., Ph.D., Director of the Laboratory of Diabetes and Obesity Research, on understanding how insulin signaling networks and innate immunity regulate metabolic functions.
During her research career, Qiong L. Zhou, Ph.D., has contributed significantly to collaborative projects with renowned scientists. In a collaborative study with Dr. Craig Mello’s laboratory while at the University of Massachusetts Medical School, she established microRNA profiles of three sets of samples from: 1. 3T3-L1 preadipocytes, adipocytes and adipocytes treated with insulin; 2. human muscle tissues from non exercised or exercised individuals; and 3. human monocytes before and after lipid perfusion by using deep sequencing technique. She is continuing to analyze these profiles to identify the major microRNAs that target the components of insulin signaling pathways and key molecules involved in diabetes and obesity. She was also part of the team that identified a new Akt substrate, TBC1D1, a RabGAP containing protein. These results were published in a paper suggesting that TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes (Zhou et al, Biochem J. 2008). While at the Sanford-Burnham Medical Research Institute, Qiong has worked on a project dissecting the role of neutrophil elastase in the development of high-fat diet induced obesity and related inflammation, insulin resistance and energy imbalance with different mouse models. This also resulted in a recent publication (Aubert et al, Cell Metabolism 2013).
Mansuy-Aubert V, Zhou QL, Xie X, Gong Z, Huang JY, Khan AR, Aubert G, Candelaria K, Thomas S, Shin DJ, Booth S, Baig SM, Bilal A, Hwang D, Zhang H, Lovell-Badge R, Smith SR, Awan FR, Jiang ZY. Imbalance between neutrophil elastase and its inhibitor α1-antitrypsin in obesity alters insulin sensitivity, inflammation, and energy expenditure. Cell Metab. 2013 Apr 2;17(4):534-48. PMID:23562077/PMC3646573.
Xie X, Gong Z, Mansuy-Aubert V, Zhou QL, Tatulian SA, Sehrt D, Gnad F, Brill LM, Motamedchaboki K, Chen Y, Czech MP, Mann M, Krüger M, Jiang ZY. C2 domain-containing phosphoprotein CDP138 regulates GLUT4 insertion into the plasma membrane. Cell Metab. 2011 Sep 7;14(3):378-89. PMID: 21907143.
Zhou QL, Jiang ZY, Mabardy AS, Del Campo CM, Lambright DG, Holik J, Fogarty KE, Straubhaar J, Nicoloro S, Chawla A, Czech MP. A novel pleckstrin homology domain-containing protein enhances insulin-stimulated Akt phosphorylation and GLUT4 translocation in adipocytes. J Biol Chem. 2010 Sep 3;285(36):27581-9. PMID: 20587420.
Walz HA, Shi XI, Chouinard M, Bue CA, Navaroli DM, Hayakawa A, Zhou QL, Nadler J, Leonard DM, Corver S. Isoform specific regulation of AKT signaling by the endosomal protein WDFY2. J. Bio.Chem. 2010 MAY 7, 285(19): 14101-8. PMID:20189988:PMC2863185.
Zhou QL, Jiang ZY, Holik J, Chawla A, Hagan GN, Leszyk J, Czech MP. Akt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes. Biochem J. 2008 May 1;411(3):647-55. PMID: 18215134.
Forman S, Zhou QL, Stewart DS. Photoactivated 3AZIOCTANOL irreversibly desensitizes muscle nicotinic ACH receptors via interaction at alphaE262. Biochemistry. 2007 Oct 23; 46(42):11911-8.
Jiang ZY, Zhou QL, Holik J, Patel S, Leszyk J, Coleman K, Chouinard M, Czech MP. Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells. J Biol Chem. 2005 Jun 3;280(22):21622-8. PMID: 15799971.
Zhou QL, Park JG, Jiang ZY, Holik J, Mitra P, Semitz S, Guilherme A, Powelka AM, Tang X, Virbasius J, Czech MP. Analysis of insulin signaling by si RNA-b ased gene Silencing. Biochemical Soc. Transactions 32:817-21. 2004. PMID: 15494023.
Jiang ZY, Zhou QL, Coleman KA, Chouinard M, Boese Q, Czech MP. Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7569-74. PMID: 12808134.
Bose A, Guilherme A, Robida SI, Nicoloro SM, Zhou QL, Jiang ZY, Pomerleau DP, Czech MP. Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c. Nature. 2002 Dec 19-26;420(6917):821-4. PMID: 12490950.
Zhou QL, Strichartz G, Davar G. Endothelin-1 activates ETA receptors to increase intracellular calcium in model sensory neurons. NeuroReport, 2001, 12(174):3853-3857. PMID:11726808.
Jiang ZY, Zhou QL, Chatterjee A, Feener EP, Myers MG Jr, White MF, King GL. Endothelin-1 modulates insulin signaling through phosphatidylinositol 3-kinase pathway in vascular smooth muscle cells. Diabetes. 1999 May;48(5):1120-30. PMID: 10331419.
Jiang ZY, Zhou QL, Eaton JW, Koppenol WH, Hunt JV, Wolff SP. Spirohydantoin inhibitors of aldose reductase inhibit iron- and copper-catalysed ascorbate oxidation in vitro. Biochem Pharmacol. 1991 Aug 22;42(6):1273-8.PMID: 1909528.
Jiang ZY, Zhou QL, Chatterjee A, Feener EP, Myers Jr. MG, White MF, King GL. Endothelin-1 modulates insulin signaling through PI3-kinase pathway in vascular smooth muscle cells. Diabetes 48:1120 -30, 1999. PMID:10331419.
Jiang ZY, Zhou QL, Eaton JW, Koppenol WH, Hunt JV, Wolff SP. Spirohydantoin inhibitors of aldose reductase inhibit iron- and copper-catalysed ascorbate oxidation in vitro. Biochem Pharmacol. 1991 Aug 22;42(6):1273-8. PMID: 1909528.
Office: The Whitaker Cardiovascular Institute, 700 Albany Street, Room W-607B, Boston, MA 02118
Lab:The Whitaker Cardiovascular Institute, 700 Albany Street, Room W-616, Boston, MA 02118