Nicholas A. Crossland, DVM, DACVP
Assistant Professor, Pathology & Laboratory Medicine
Biography
Dr. Crossland is a board certified Veterinary Anatomic Pathologist. He shares a dual appointment as an Assistant Professor in the Department of Pathology and Laboratory Medicine at Chobanian and Avedisian School of Medicine and an Investigator at the NEIDL where he directs the NEIDL Comparative Pathology Laboratory (NCPL).
His lab aims to elucidate pathogen-host interactions of highly pathogenic microbes. His lab complements classic pathology approaches with cutting edge technologies such as high throughput tissue staining, spatial transcriptomics and quantitative image analysis. This approach enables the discovery of biological pathways driving and preventing disease. At the translational level, we use our expertise to evaluate the efficacy of medical counter measures with the ultimate goal of alleviating and preventing human suffering.
His lab mentors both MS and PhD students that have their sites on pursuing a career in translational research. He is actively exploring collaborative opportunities with other BUMC faculty members to push the outputs achieved from tissue based assays to drive discovery and enhance our understanding of host-pathogen interactions.
Other Positions
- Faculty, National Emerging Infectious Disease Lab, Boston University
- Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
Education
- Kansas State University, DVM
- Kansas State University, BS
Publications
- Published on 3/1/2025
Le Sage V, Werner BD, Merrbach GA, Petnuch SE, O'Connell AK, Simmons HC, McCarthy KR, Reed DS, Moncla LH, Bhavsar D, Krammer F, Crossland NA, McElroy AK, Duprex WP, Lakdawala SS. Influenza A(H5N1) Immune Response among Ferrets with Influenza A(H1N1)pdm09 Immunity. Emerg Infect Dis. 2025 Mar; 31(3):477-487. PMID: 40023796.
Read at: PubMed - Published on 2/25/2025
Soucy AM, Brune JE, Jayaraman A, Shenoy AT, Korkmaz FT, Etesami NS, Hiller BE, Martin IM, Goltry WN, Ha CT, Crossland NA, Campbell JD, Beach TG, Traber KE, Jones MR, Quinton LJ, Bosmann M, Frevert CW, Mizgerd JP. Transcriptomic responses of lung mesenchymal cells during pneumonia. JCI Insight. 2025 Feb 25. PMID: 39998887.
Read at: PubMed - Published on 2/20/2025
Lata S, Yabaji SM, O'Connell AK, Gertje HP, Kirber MT, Crossland NA, Kramnik I. Protocol for 3D multiplexed fluorescent imaging of pulmonary TB lesions using Opal-TSA dyes for signal amplification. STAR Protoc. 2025 Mar 21; 6(1):103640. PMID: 39982826.
Read at: PubMed - Published on 2/6/2025
Guo W, Crossland N, Crott JW. Mediterranean diet improves liver health but does not protect against azoxymethane-induced colon tumorigenesis compared to Western diet in A/J mice. Exp Mol Pathol. 2025 Mar; 141:104953. PMID: 39919552.
Read at: PubMed - Published on 2/4/2025
Subramaniam S, Jose A, Kenney D, O'Connell AK, Bosmann M, Douam F, Crossland N. Challenging the notion of endothelial infection by SARS-CoV-2: insights from the current scientific evidence. Front Immunol. 2025; 16:1443932. PMID: 39967675.
Read at: PubMed - Published on 10/23/2024
Le Sage V, Werner BD, Merrbach GA, Petnuch SE, O'Connell AK, Simmons HC, McCarthy KR, Reed DS, Moncla LH, Bhavsar D, Krammer F, Crossland NA, McElroy AK, Duprex WP, Lakdawala SS. Pre-existing H1N1 immunity reduces severe disease with bovine H5N1 influenza virus. bioRxiv. 2024 Oct 23. PMID: 39484442.
Read at: PubMed - Published on 9/16/2024
Rathnasinghe R, Chang LA, Pearl R, Jangra S, Aspelund A, Hoag A, Yildiz S, Mena I, Sun W, Loganathan M, Crossland NA, Gertje HP, Tseng AE, Aslam S, Albrecht RA, Palese P, Krammer F, Schotsaert M, Muster T, García-Sastre A. Sequential immunization with chimeric hemagglutinin ?NS1 attenuated influenza vaccines induces broad humoral and cellular immunity. NPJ Vaccines. 2024 Sep 16; 9(1):169. PMID: 39300090.
Read at: PubMed - Published on 6/17/2024
Berggren KA, Sinha S, Lin AE, Schwoerer MP, Maya S, Biswas A, Cafiero TR, Liu Y, Gertje HP, Suzuki S, Berneshawi AR, Carver S, Heller B, Hassan N, Ali Q, Beard D, Wang D, Cullen JM, Kleiner RE, Crossland NA, Schwartz RE, Ploss A. Liver-specific Mettl14 deletion induces nuclear heterotypia and dysregulates RNA export machinery. bioRxiv. 2024 Jun 17. PMID: 38948765.
Read at: PubMed - Published on 6/7/2024
Subramaniam S, Kenney D, Jayaraman A, O'Connell AK, Walachowski S, Montanaro P, Reinhardt C, Colucci G, Crossland NA, Douam F, Bosmann M. Aging is associated with an insufficient early inflammatory response of lung endothelial cells in SARS-CoV-2 infection. Front Immunol. 2024; 15:1397990. PMID: 38911865.
Read at: PubMed - Published on 5/20/2024
Mei M, Cupic A, Miorin L, Ye C, Cagatay T, Zhang K, Patel K, Wilson N, McDonald WH, Crossland NA, Lo M, Rutkowska M, Aslam S, Mena I, Martinez-Sobrido L, Ren Y, García-Sastre A, Fontoura BMA. Inhibition of mRNA nuclear export promotes SARS-CoV-2 pathogenesis. Proc Natl Acad Sci U S A. 2024 May 28; 121(22):e2314166121. PMID: 38768348.
Read at: PubMed
View 48 more publications: View full profile at BUMC