Michael Blower, PhD
Professor, Biochemistry & Cell Biology
Biography
Mike Blower is a Professor of Cell Biology and Biochemistry at the Chobanian and Avedisian School of Medicine at Boston University.
Mike received his B.A. from Miami University (Ohio), his Ph.D. from the University of California, San Diego under the mentorship of Gary Karpen. He was a Damon Runyon Postdoctoral Fellow at the University of California, Berkeley with Rebecca Heald and Karsten Weis. Following his postdoctoral training he was an Assistant and Associate Professor of Genetics at Harvard Medical School while managing a research lab in the Department of Molecular Biology at Massachusetts General Hospital. He is the recipient of a Burroughs-Wellcome Fund career Award in the Biomedical Sciences and many different grants from the NIH.
Mike’s current work focuses on the interaction of RNA with chromatin and how these interactions influence chromatin structure and gene expression. Additionally his lab studies the regulation of chromatin:RNA interactions throughout the cell cycle. His lab uses a multidisciplinary approach that integrates, cell biology, in vitro reconstitution, genomics and bioinformatics, and CRISPR genome engineering.
Education
- University of California, San Diego, PhD
- Miami University, BA
Publications
- Published on 9/10/2024
Sharp JA, Sparago E, Thomas R, Alimenti K, Wang W, Blower MD. Role of the SAF-A SAP domain in X inactivation, transcription, splicing, and cell proliferation. bioRxiv. 2024 Sep 10. PMID: 39314300.
Read at: PubMed - Published on 8/7/2023
Park S, Dahn R, Kurt E, Presle A, VanDenHeuvel K, Moravec C, Jambhekar A, Olukoga O, Shepherd J, Echard A, Blower M, Skop AR. The mammalian midbody and midbody remnant are assembly sites for RNA and localized translation. Dev Cell. 2023 Oct 09; 58(19):1917-1932.e6. PMID: 37552987.
Read at: PubMed - Published on 2/15/2023
Blower MD, Wang W, Sharp JA. Differential nuclear import regulates nuclear RNA inheritance following mitosis. Mol Biol Cell. 2023 Apr 01; 34(4):ar32. PMID: 36790906.
Read at: PubMed - Published on 3/22/2021
Perea-Resa C, Wattendorf L, Marzouk S, Blower MD. Cohesin: behind dynamic genome topology and gene expression reprogramming. Trends Cell Biol. 2021 09; 31(9):760-773. PMID: 33766521.
Read at: PubMed - Published on 1/7/2021
Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul I, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M, Perissi V, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN, Wilson AA, Mühlberger E, Emili A. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Mol Cell. 2021 Jan 07; 81(1):212. PMID: 33417854.
Read at: PubMed - Published on 12/24/2020
Ardehali MB, Damle M, Perea-Resa C, Blower MD, Kingston RE. Elongin A associates with actively transcribed genes and modulates enhancer RNA levels with limited impact on transcription elongation rate in vivo. J Biol Chem. 2021 Jan-Jun; 296:100202. PMID: 33334895.
Read at: PubMed - Published on 11/19/2020
Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul I, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M, Perissi V, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN, Wilson AA, Mühlberger E, Emili A. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Mol Cell. 2020 12 17; 80(6):1104-1122.e9. PMID: 33259812.
Read at: PubMed - Published on 11/2/2020
Sharp JA, Perea-Resa C, Wang W, Blower MD. Cell division requires RNA eviction from condensing chromosomes. J Cell Biol. 2020 11 02; 219(11). PMID: 33053167.
Read at: PubMed - Published on 2/7/2020
Perea-Resa C, Bury L, Cheeseman IM, Blower MD. Cohesin Removal Reprograms Gene Expression upon Mitotic Entry. Mol Cell. 2020 04 02; 78(1):127-140.e7. PMID: 32035037.
Read at: PubMed - Published on 1/2/2020
Yang F, Wang W, Cetinbas M, Sadreyev RI, Blower MD. Genome-wide analysis identifies cis-acting elements regulating mRNA polyadenylation and translation during vertebrate oocyte maturation. RNA. 2020 03; 26(3):324-344. PMID: 31896558.
Read at: PubMed
View 29 more publications: View full profile at BUMC