Mark W. Logue, PhD

Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

My research involves the use of computational tools to search the human genome for genetic variants influencing risk of psychiatric and neurological disorders including panic disorder, post-traumatic stress disorder, and Alzheimer’s disease. The genetics of these traits is complex, as multiple genes interact with environmental factors to determine an individual’s risk. When studying psychiatric traits, this complexity is compounded because psychiatric disorders are not distinct at the genetic level. For example, genetic variants that increase risk of developing panic disorder may also predispose an individual to bipolar disorder or phobias. To unravel this complexity, information must be integrated from a variety of sources, including families with a multiple affected individuals, large case-control study samples, and samples from different ancestral populations. The type of genetic data that can be examined is similarly diverse and can include microsatellite markers, single nucleotide polymorphisms, and base-pair level sequence data. By leveraging these multiple sources of data, and by using analysis methods that allow for this complexity at both the genetic and trait level, the presence of disease can be correlated with variants across multiple genes. The identification of these variants can implicate new biological systems or molecular pathways which are disrupted, potentially resulting in the development of new biomarkers of disease, new treatments, or personalized therapies based on a patient’s genetic profile.

Publications

  • Published 7/2/2026

    Mufford MS, van der Meer D, Baird CL, Sun D, LaBar KS, Ramesar R, Hussain A, Abdallah CG, Andrew E, Averill CL, Baker JT, Baugh LA, Blackford JU, Bomyea J, Bryant RA, Ching CRK, Choi K, Cotton AS, Daniels JK, Davenport ND, Davidson RJ, De Bellis MD, Dennis EL, Densmore M, deRoon-Cassini TA, Disner SG, du Plessis S, Etkin A, Fani N, Fercho KA, Fitzgerald J, Geuze E, Gordon EM, Grupe DW, Harpaz-Rotem I, Russel CC, Herzog JI, Hofmann D, Hudson AR, Ipser J, Jahanshad N, Jovanovic T, Kaufman ML, Koch SBJ, Koerte IK, Korgaonkar MS, Krystal JH, Lanius R, Larson C, Lebois LAM, Levy I, Li G, Liberzon I, Logue MW, Magnotta VA, Manthey A, Maron-Katz A, May G, McLaughlin KA, Mueller SC, Nawijn L, Nelson SM, Neria Y, Neufeld RWJ, Nitschke JB, O'Leary EN, Olatunji BO, Olff M, Olson EA, Peverill M, Phan KL, Pineda E, Ressler KJ, Rosso IM, Salminen LE, Meltzer K, Schmahl C, Seedat S, Sharp CA, Shenton ME, Sierk A, Simons RM, Simons JS, Sponheim SR, Stein MB, Stevens JS, Straube T, Suarez-Jimenez B, Théberge J, Thomopolous SI, van der Wee NJA, van der Werff SJA, van Erp TGM, van Rooij SJH, van Zuiden M, Veltman DJ, Vermeiren RRJM, Walter H, Wang X, Wang L, Xie H, Zhu X, Zhu Y, Thompson PM, Andreassen OA, Stein DJ, Morey RA, Dalvie S. Shared and specific associations of amygdala nuclei volumes with PTSD symptom domains and childhood trauma: An ENIGMA-PGC PTSD mega-analysis. Mol Psychiatry. 2026 Jul 02. PMID: 42393252.

    Read at: PubMed

  • Published 6/17/2026

    Wolf EJ, Zhao X, Hao S, Lawhorn C, Carbaugh J, Fortier CB, Milberg WP, Logue MW, Miller MW. PTSD Severity-Related Accelerated Aging, Hippocampal Volume, and CLDN5 DNA Methylation. Biopsychosoc Sci Med. 2026 Jun 17. PMID: 42300138.

    Read at: PubMed

  • Published 6/9/2026

    Grillo AR, Wallander SE, McCormick BM, Zhao X, Logue MW, Miller MW, Wolf EJ. A longitudinal study of CLDN5 DNA methylation and PTSD. J Behav Med. 2026 Jun 09. PMID: 42262642.

    Read at: PubMed

  • Published 6/3/2026

    Shao Y, Yin Y, Cheng Y, McGeary JE, Taveira TH, Tsuang DW, Logue MW, Ayandeh S, Ahmed A, Zamrini E, Zeng-Treitler Q. Medication-Wide Association Study of Alzheimer's Disease and Related Dementias: Identifying Drug Candidates from Electronic Health Records through Explainable AI. medRxiv. 2026 Jun 03. PMID: 42282197.

    Read at: PubMed

  • Published 5/28/2026

    Clark AL, Valocchi E, McGill MB, Lopez FV, Chanfreau-Coffinier C, Thomas KR, Jester DJ, Logue MW, Merritt VC. Examining the additive risk of TBI and comorbid conditions on dementia in military veterans: a retrospective cohort study. Alzheimers Res Ther. 2026 May 28; 18(1). PMID: 42210358.

    Read at: PubMed

Other Positions

  • Professor, Biostatistics
    Boston University School of Public Health
  • Investigator
    Framingham Heart Study
  • Member, Evans Center for Interdisciplinary Biomedical Research
    Boston University
  • Statistician, National Center for PTSD
    VA Boston Healthcare System
  • Member, Genome Science Institute
    Boston University

Education

  • University of Iowa, PhD
  • University of Iowa, MS
  • University of Oregon, BS