Mark W. Logue, PhD

Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

My research involves the use of computational tools to search the human genome for genetic variants influencing risk of psychiatric and neurological disorders including panic disorder, post-traumatic stress disorder, and Alzheimer’s disease. The genetics of these traits is complex, as multiple genes interact with environmental factors to determine an individual’s risk. When studying psychiatric traits, this complexity is compounded because psychiatric disorders are not distinct at the genetic level. For example, genetic variants that increase risk of developing panic disorder may also predispose an individual to bipolar disorder or phobias. To unravel this complexity, information must be integrated from a variety of sources, including families with a multiple affected individuals, large case-control study samples, and samples from different ancestral populations. The type of genetic data that can be examined is similarly diverse and can include microsatellite markers, single nucleotide polymorphisms, and base-pair level sequence data. By leveraging these multiple sources of data, and by using analysis methods that allow for this complexity at both the genetic and trait level, the presence of disease can be correlated with variants across multiple genes. The identification of these variants can implicate new biological systems or molecular pathways which are disrupted, potentially resulting in the development of new biomarkers of disease, new treatments, or personalized therapies based on a patient’s genetic profile.

Publications

  • Published 1/12/2026

    Wolf EJ, Zhao X, Madison A, Carbaugh J, Fortier CB, Milberg WP, Logue MW, Miller MW. Trauma exposure, PTSD, and methylation of the blood brain barrier claudin-5 gene. Psychoneuroendocrinology. 2026 Apr; 186:107753. PMID: 41547340.

    Read at: PubMed

  • Published 11/25/2025

    Wolf EJ, Zhao X, Madison A, Carbaugh J, Fortier CB, Milberg WP, Logue MW, Miller MW. Trauma Exposure, PTSD, and Methylation of the Blood Brain Barrier Claudin-5 Gene. medRxiv. 2025 Nov 25. PMID: 41358302.

    Read at: PubMed

  • Published 9/27/2025

    Kurniansyah N, Tasaki S, Rehman H, Zhu C, Farrell J, Sherva R, Hauger R, Merritt VC, Panizzon M, Zhang R, Gaziano JM, Gim J, Lee K, Lee DY, Nho K, Vialle RA, Mukherjee S, Trittschuh EH, Lee AJ, Brickman AM, Cruchaga C, Risacher S, Greve DN, Crane P, Martin E, Bush W, Mayeux R, Haines JL, Pericak-Vance MA, Logue M, Bennett DA, Barnes LL, Saykin A, Hohman T, Wang LS, Schellenberg GC, Ang TFA, Au R, Mez J, Lunetta KL, Zhang X, Farrer LA. A multi-ancestry polygenic risk score for Alzheimer disease is associated with cognitive decline, hippocampal atrophy and neuropathological hallmarks in diverse populations. medRxiv. 2025 Sep 27. PMID: 41040715.

    Read at: PubMed

  • Published 9/19/2025

    Brown K, Shutes-David A, Wilson K, Shao Y, Logue M, Zeng QT, Tsuang DW. Machine learning-based risk scores are associated with conversion to dementia in Veterans. J Alzheimers Dis. 2025 Nov; 108(2):873-882. PMID: 40971323.

    Read at: PubMed

  • Published 9/10/2025

    Miller MW, Zhao X, Wolf EJ, Milberg WP, Fortier CB, Logue MW. Genetic and epigenetic analysis of plasma glial fibrillary acidic protein (GFAP) levels in PTSD. Mol Psychiatry. 2026 Jan; 31(1):352-361. PMID: 40931166.

    Read at: PubMed

View All 179 Publications:   View Full Profile in BUMC

Other Positions

  • Professor, Biostatistics
    Boston University School of Public Health
  • Investigator
    Framingham Heart Study
  • Member, Evans Center for Interdisciplinary Biomedical Research
    Boston University
  • Statistician, National Center for PTSD
    VA Boston Healthcare System
  • Member, Genome Science Institute
    Boston University

Websites

Education

  • University of Iowa, PhD
  • University of Iowa, MS
  • University of Oregon, BS

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