Mark W. Logue, PhD

Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

My research involves the use of computational tools to search the human genome for genetic variants influencing risk of psychiatric and neurological disorders including panic disorder, post-traumatic stress disorder, and Alzheimer’s disease. The genetics of these traits is complex, as multiple genes interact with environmental factors to determine an individual’s risk. When studying psychiatric traits, this complexity is compounded because psychiatric disorders are not distinct at the genetic level. For example, genetic variants that increase risk of developing panic disorder may also predispose an individual to bipolar disorder or phobias. To unravel this complexity, information must be integrated from a variety of sources, including families with a multiple affected individuals, large case-control study samples, and samples from different ancestral populations. The type of genetic data that can be examined is similarly diverse and can include microsatellite markers, single nucleotide polymorphisms, and base-pair level sequence data. By leveraging these multiple sources of data, and by using analysis methods that allow for this complexity at both the genetic and trait level, the presence of disease can be correlated with variants across multiple genes. The identification of these variants can implicate new biological systems or molecular pathways which are disrupted, potentially resulting in the development of new biomarkers of disease, new treatments, or personalized therapies based on a patient’s genetic profile.

Publications

  • Published 6/9/2026

    Grillo AR, Wallander SE, McCormick BM, Zhao X, Logue MW, Miller MW, Wolf EJ. A longitudinal study of CLDN5 DNA methylation and PTSD. J Behav Med. 2026 Jun 09. PMID: 42262642.

    Read at: PubMed

  • Published 5/28/2026

    Clark AL, Valocchi E, McGill MB, Lopez FV, Chanfreau-Coffinier C, Thomas KR, Jester DJ, Logue MW, Merritt VC. Examining the additive risk of TBI and comorbid conditions on dementia in military veterans: a retrospective cohort study. Alzheimers Res Ther. 2026 May 28. PMID: 42210358.

    Read at: PubMed

  • Published 5/7/2026

    Sherva R, Bayly H, Zhang R, Harrington K, Mez J, Miller MW, Tsuang D, Wolf E, Zeng Q, Le Guen Y, Tejeda M, Gaziano JM, Panizzon MS, Hauger RL, Merritt VC, Farrer LA, Logue MW. A Genome-wide Association Study of Alzheimer's Disease and Dementia in a Large Multi-ancestry Military Cohort Identifies Many New Dementia-Associated Loci. medRxiv. 2026 May 07. PMID: 42145619.

    Read at: PubMed

  • Published 5/6/2026

    Cook N, Zeng Y, Yang C, Jiang Z, Wang TC, Le Guen Y, Cody K, Johnson M, Zhang R, Merritt VC, Hauger RL, Koran ME, Mormino EC, Gordon B, DeCasien A, Andrews S, Dumitrescu L, Archer D, Hohman TJ, Pottier C, Cruchaga C, Sherva R, Logue M, Napolioni V, Greicius MD, Belloy ME. An APOE *4-Informed Genomic Atlas of the X Chromosome in Alzheimer's Disease. medRxiv. 2026 May 06. PMID: 42145643.

    Read at: PubMed

  • Published 3/10/2026

    Clark AL, Asimakopoulos G, Valocchi E, Chanfreau-Coffinier C, McGill M, Thomas KR, Jester DJ, Logue MW, Merritt VC. Individual-Level Factors Associated With 10-Year Incidence of Alzheimer Disease and Related Dementias in the VA Million Veteran Program. Neurology. 2026 Apr 14; 106(7):e214748. PMID: 41805402.

    Read at: PubMed

View All 186 Publications:   View Full Profile in BUMC

Other Positions

  • Professor, Biostatistics
    Boston University School of Public Health
  • Investigator
    Framingham Heart Study
  • Member, Evans Center for Interdisciplinary Biomedical Research
    Boston University
  • Statistician, National Center for PTSD
    VA Boston Healthcare System
  • Member, Genome Science Institute
    Boston University

Websites

Education

  • University of Iowa, PhD
  • University of Iowa, MS
  • University of Oregon, BS

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