Mark W. Logue, Ph.D.
Research Assistant Professor, Dept of Medicine (Biomedical Genetics), BUSM
Statistician, Research, VA Boston Healthcare System
2001-2002 NIMH Post-Doctoral Research Fellow, Psychiatry, University of Iowa, Iowa City IA.
2001 – PhD Statistics – University of Iowa, Iowa City IA.
1996 – MS in Statistics – University of Iowa, Iowa City IA.
1994 – BS in Mathematics – University of Oregon, Eugene OR.
My research involves the use of computational tools to search the human genome for genetic variants influencing risk of psychiatric and neurological disorders including panic disorder, post-traumatic stress disorder, and Alzheimer’s disease. The genetics of these traits is complex, as multiple genes interact with environmental factors to determine an individual’s risk. When studying psychiatric traits, this complexity is compounded because psychiatric disorders are not distinct at the genetic level. For example, genetic variants that increase risk of developing panic disorder may also predispose an individual to bipolar disorder or phobias. To unravel this complexity, information must be integrated from a variety of sources, including families with a multiple affected individuals, large case-control study samples, and samples from different ancestral populations. The type of genetic data that can be examined is similarly diverse and can include microsatellite markers, single nucleotide polymorphisms, and base-pair level sequence data. By leveraging these multiple sources of data, and by using analysis methods that allow for this complexity at both the genetic and trait level, the presence of disease can be correlated with variants across multiple genes. The identification of these variants can implicate new biological systems or molecular pathways which are disrupted, potentially resulting in the development of new biomarkers of disease, new treatments, or personalized therapies based on a patient’s genetic profile.
Logue MW, Schu M, Vardarajan B, Farrell J, Bennett DA, Buxbaum JD, Byrd GS, Ertekin-Taner N, Evans D, Foroud T, Goate A, Graff-Radford NR, Kamboh MI, Kukull WA, Manly JJ, Alzheimer Disease Genetics Consortium, Haines JL, Mayeux R, Pericak-Vance MA, Schellenberg GD, Lunetta KL, Baldwin CT, Fallin MD, Farrer LA. 2014. Two rare AKAP9 variants are associated with Alzheimer disease in African Americans. Alzheimer and Dementia 10(6):609-618.e11. PMCID: PMC4253055.
Logue MW, Schu MS, Vardarajan BN, Farrell J, Lunetta LK, Jun G, Baldwin CT, DeAngelis MM, Farrer LA, 2014. A search for AMD risk variants in Alzheimer disease genes and pathways. Neurobiology of Aging. 35(6):1510.e7-1510.e18. PMCID: PMC3961547
Logue MW, Solovieff N, Leussis MP, Wolf EJ, Melista E, Baldwin C, Koenen KC, Petryshen T, Miller MW. 2013. The ankyrin-3 gene is associated with posttraumatic stress disorder and externalizing comorbidity. Psychoneuroendocrinology 38(10), 2249-2257. PMCID: PMC3775967
Logue MW, Baldwin C, Guffanti G, Melista E, Wolf EJ, Reardon AF, Uddin M, Wildman D, Galea S, Koenen KC, Miller MW. 2013. A genome-wide association study of post-traumatic stress disorder identifies the retinoid-related orphan receptor alpha (RORA) gene as a significant risk locus. Molecular Psychiatry. 18, 397-342. PMCID: PMC3494788.
Reitz C, Jun G, Naj A, Rajbhandary R,Vardarajan B, Wang L, PhD; Valladares O, Lin C, Larson EB, Graff-Radford NR, Evans D, MD; Philip L. De Jager PL, MD, PhD; Crane PK, MD, MPH; Buxbaum JD, Murrell JR, Raj T, Ertekin-Taner N, Logue M, Baldwin CT, Green RC, MD, MPH; Barnes LL, Cantwell LB, Fallin MD, Go RCP, Griffith P, Obisesan TO, Manly JJ, Lunetta KL, Kamboh MI, Lopez OL, Bennett DA, Hendrie H, Hall KS, Goate AM, Byrd GS, Kukull WA, Foroud TM, Haines JL, Farrer LA, Pericak-Vance MA, Schellenberg GD, Mayeux R, for the Alzheimer Disease Genetics Consortium. 2013. Variants in the ATP-Binding Cassette Transporter (ABCA7), Apolipoprotein E ϵ4,and the Risk of Late-Onset Alzheimer Disease in African Americans. JAMA. 309(14):1483-1492. PMCID: PMC3667653.
Farrer L, Logue M. 2012. Collection of Clinical and Epidemiological Data for Genetic Linkage and Association Studies. Current Protocols in Human Genetics, 1.1.1-1.1.20.
Logue MW, Bauver SR, Knowles JA, Gameroff MJ, Weissman MM, Crowe RR, Fyer AJ, Hamilton SP. 2012. Multivariate analysis of anxiety disorders yields further evidence of linkage to chromosomes 4q21, and 7p in panic disorder families. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics) 159B:247-280. PMCID: PMC3306232.
Logue MW, Schu, M, Vardarajan BN, Buros, J, Green RC, Go RCP, Griffith, P, Obisesan, TO, Shatz R, Borenstein A, Cupples, LA, Lunetta KL, Fallin MD, Baldwin CT, Farrer LA. 2011. A Comprehensive Genetic Association Study of Alzheimer Disease in African Americans. Archives of Neurology, 68:1569-1579. PMCID: PMC3356921.
Logue MW, Posner H, Green RC, Moline M, Cupples LA, Lunetta KL, Zou H, Hurt SW, Farrer LA, DeCarli C. 2011. MRI-measured atrophy and its relationship to cognitive functioning in vascular dementia and Alzheimer’s disease patients. Alzheimer and Dementia. 7: 493-500. PMCID: PMC3166967.
Logue MW, Vieland VJ, Goedken RJ, Crowe RR. 2003. Bayesian Analysis of a Previously Published Genome Screen for Panic Disorder Reveals New and Compelling Evidence for Linkage to Chromosome 7. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics) 121B: 95-99. PMID: 12898582
Bartlett, CW, Flax JF, Logue MW, Vieland VJ, Bassett AS, Tallal P, and Brzustowicz LM. 2002. A Major Susceptibility Locus for Specific Language Impairment is located on 13q21 American Journal of Human Genetics 71: 45-55. PMCID: PMC384992
Vieland VJ, Logue, M. 2002. HLODs, trait models, and ascertainment: Implications of admixture for parameter estimation and linkage detection, Human Heredity 53: 23-35. PMID: 11901268