Kostas Alysandratos, MD, PHD

Assistant Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Konstantinos Alysandratos, MD, PhD is an Assistant Professor in the Pulmonary, Allergy, Sleep & Critical Care Medicine Section at Boston University Chobanian & Avedisian School of Medicine and serves as Co-Director of the Interstitial Lung Disease (ILD) Clinic at Boston Medical Center, where he specializes in the treatment of complex lung diseases. He is also a Principal Investigator at the Center for Regenerative Medicine (CReM) of Boston University and Boston Medical Center, leading an NIH-funded research program aimed at advancing the understanding of pulmonary fibrosis pathogenesis and identifying druggable targets, particularly within the alveolar epithelium, using pluripotent stem cell model systems. Dr. Alysandratos earned his MD and PhD degrees from the University of Athens in Greece, completed his internal medicine residency at the University of Texas Southwestern Medical Center, and completed fellowships in Sleep Medicine and Pulmonary/Critical Care Medicine at Boston University.

Publications

  • Published 7/1/2025

    Rodríguez LR, Alysandratos KD, Katzen J, Murthy A, Roque Barboza W, Tomer Y, Bui S, Acín-Pérez R, Petcherski A, Minakin K, Carson P, Iyer S, Chavez K, Cooper CH, Babu A, Weiner AI, Vaughan AE, Arany Z, Shirihai OS, Kotton DN, Beers MF. Impaired AMPK control of alveolar epithelial cell metabolism promotes pulmonary fibrosis. JCI Insight. 2025 Aug 08; 10(15). PMID: 40591409.

    Read at: PubMed

  • Published 6/12/2025

    Caobi A, Su CM, Beusch CM, Kenney D, Darling TL, Feng S, Semaan M, Wacquiez A, Sanders NL, Tully ES, Chen DY, Evdokimova M, Ding Z, Jones D, Alysandratos KD, Mizgerd JP, Kirchdoerfer RN, Kotton DN, Douam F, Crossland NA, Boon ACM, Gordon DE, Baker SC, Saeed M. SARS-CoV-2 nsp15 enhances viral virulence by subverting host antiviral defenses. Proc Natl Acad Sci U S A. 2025 Jun 17; 122(24):e2426528122. PMID: 40504150.

    Read at: PubMed

  • Published 3/5/2025

    Burgess CL, Ayers LJ, Minakin K, Alysandratos KD, Varelas X, Kotton DN. Protocol for the differentiation of human alveolar epithelial type I cells from pluripotent stem cell-derived type II-like cells. STAR Protoc. 2025 Mar 21; 6(1):103667. PMID: 40048418.

    Read at: PubMed

  • Published 3/4/2025

    Evdokimova M, Feng S, Caobi A, Moreira FR, Jones D, Alysandratos KD, Tully ES, Kotton DN, Boyd DF, Banach BS, Kirchdoerfer RN, Saeed M, Baker SC. Coronavirus endoribonuclease antagonizes ZBP1-mediated necroptosis and delays multiple cell death pathways. Proc Natl Acad Sci U S A. 2025 Mar 11; 122(10):e2419620122. PMID: 40035769.

    Read at: PubMed

  • Published 12/12/2024

    Eiken MK, Childs CJ, Brastrom LK, Frum T, Plaster EM, Ahmed DW, Spencer RC, Shachaf O, Pfeiffer S, Levine JE, Alysandratos KD, Kotton DN, Spence JR, Loebel C. Nascent matrix deposition supports alveolar organoid formation from aggregates in synthetic hydrogels. Stem Cell Reports. 2025 Jan 14; 20(1):102376. PMID: 39672155.

    Read at: PubMed

View All 57 Publications:   View Full Profile in BUMC

Other Positions

  • Member, Pulmonary Center
    Boston University
  • Member, Center for Regenerative Medicine
    Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research
    Boston University

Websites

Education

  • University of Athens, MD
  • University of Athens, PhD

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