Karl C. Kuban, MD

Emeritus Professor, Pediatrics

Karl Kuban


Karl Kuban brings depth and breadth in clinical care, research and teaching to his role as Chief of the Pediatric Neurology Division at Boston Medical Center. Dr. Kuban was resident training coordinator in Pediatric Neurology at both Children’s Hospital Boston, where he was on staff for 16 years, and at Tufts-New England Medical Center, where he was Associate Chief for 8 years. He has authored more than 70 original peer-reviewed publications, has created an interactive training CD/video for conducting a pediatric neurological examination, and has received awards for teaching and patient care.

Dr. Kuban completed his pediatrics training at Children’s Hospital Boston and his neurology training in the Longwood Area/Children’s Hospital Neurological Training Program. Dr. Kuban obtained a master’s degree in epidemiology from the Harvard School of Public Health and he has had a broad range of research interests, including ones focused on neonatal neurology, cerebral palsy, childhood stroke, autism and brain injury related to congenital heart disease. He currently serves as co-principal investigator for a multi-center NIH study looking at biological markers in the bloods of babies born under 28 weeks gestation.

Other Positions

  • Emeritus Professor, Neurology, Boston University Chobanian & Avedisian School of Medicine
  • Boston Medical Center


  • University of Miami, MD
  • Ohio State University, BSc
  • Harvard School of Public Health, SM/ScM


  • Published on 10/7/2023

    Freedman AN, Roell K, Engwall E, Bulka C, Kuban KCK, Herring L, Mills CA, Parsons PJ, Galusha A, O'Shea TM, Fry RC. Prenatal Metal Exposure Alters the Placental Proteome in a Sex-Dependent Manner in Extremely Low Gestational Age Newborns: Links to Gestational Age. Int J Mol Sci. 2023 Oct 07; 24(19). PMID: 37834424.

    Read at: PubMed
  • Published on 8/23/2023

    Santos HP, Enggasser AE, Clark J, Roell K, Zhabotynsky V, Gower WA, Yanni D, Yang NG, Washburn L, Gogcu S, Marsit CJ, Kuban K, O'Shea TM, Fry RC. Sexually dimorphic methylation patterns characterize the placenta and blood from extremely preterm newborns. BMC Biol. 2023 Aug 23; 21(1):173. PMID: 37608375.

    Read at: PubMed
  • Published on 5/17/2023

    Frazier JA, Li X, Kong X, Hooper SR, Joseph RM, Cochran DM, Kim S, Fry RC, Brennan PA, Msall ME, Fichorova RN, Hertz-Picciotto I, Daniels JL, Lai JS, Boles RE, Zvara BJ, Jalnapurkar I, Schweitzer JB, Singh R, Posner J, Bennett DH, Kuban KCK, O'Shea TM. Perinatal Factors and Emotional, Cognitive, and Behavioral Dysregulation in Childhood and Adolescence. J Am Acad Child Adolesc Psychiatry. 2023 Dec; 62(12):1351-1362. PMID: 37207889.

    Read at: PubMed
  • Published on 3/20/2023

    Freedman AN, Clark J, Eaves LA, Roell K, Oran A, Koval L, Rager J, Santos HP, Kuban K, Joseph RM, Frazier J, Marsit CJ, Burt AA, O'Shea TM, Fry RC. A multi-omic approach identifies an autism spectrum disorder (ASD) regulatory complex of functional epimutations in placentas from children born preterm. Autism Res. 2023 May; 16(5):918-934. PMID: 36938998.

    Read at: PubMed
  • Published on 11/1/2022

    Jensen ET, Yi J, Jackson W, Singh R, Joseph RM, Kuban KCK, Msall ME, Washburn L, Fry R, South AM, O'Shea TM. Analysis of Neurodevelopment in Children Born Extremely Preterm Treated With Acid Suppressants Before Age 2 Years. JAMA Netw Open. 2022 Nov 01; 5(11):e2241943. PMID: 36378311.

    Read at: PubMed
  • Published on 10/28/2022

    Marable CA, Roell K, Kuban K, O'Shea TM, Fry RC. Placental transcriptional signatures associated with cerebral white matter damage in the neonate. Front Neurosci. 2022; 16:1017953. PMID: 36389237.

    Read at: PubMed
  • Published on 10/20/2022

    Cochran DM, Jensen ET, Frazier JA, Jalnapurkar I, Kim S, Roell KR, Joseph RM, Hooper SR, Santos HP, Kuban KCK, Fry RC, O'Shea TM. Association of prenatal modifiable risk factors with attention-deficit hyperactivity disorder outcomes at age 10 and 15 in an extremely low gestational age cohort. Front Hum Neurosci. 2022; 16:911098. PMID: 36337853.

    Read at: PubMed
  • Published on 9/8/2022

    Freedman AN, Eaves LA, Rager JE, Gavino-Lopez N, Smeester L, Bangma J, Santos HP, Joseph RM, Kuban KC, O'Shea TM, Fry RC. The placenta epigenome-brain axis: placental epigenomic and transcriptomic responses that preprogram cognitive impairment. Epigenomics. 2022 Aug; 14(15):897-911. PMID: 36073148.

    Read at: PubMed
  • Published on 8/18/2022

    O'Shea TM, Register HM, Yi JX, Jensen ET, Joseph RM, Kuban KCK, Frazier JA, Washburn L, Belfort M, South AM, Santos HP, Shenberger J, Perrin EM, Thompson AL, Singh R, Rollins J, Gogcu S, Sanderson K, Wood C, Fry RC. Growth During Infancy After Extremely Preterm Birth: Associations with Later Neurodevelopmental and Health Outcomes. J Pediatr. 2023 Jan; 252:40-47.e5. PMID: 35987367.

    Read at: PubMed
  • Published on 7/14/2022

    Wu YW, Comstock BA, Gonzalez FF, Mayock DE, Goodman AM, Maitre NL, Chang T, Van Meurs KP, Lampland AL, Bendel-Stenzel E, Mathur AM, Wu TW, Riley D, Mietzsch U, Chalak L, Flibotte J, Weitkamp JH, Ahmad KA, Yanowitz TD, Baserga M, Poindexter BB, Rogers EE, Lowe JR, Kuban KCK, O'Shea TM, Wisnowski JL, McKinstry RC, Bluml S, Bonifacio S, Benninger KL, Rao R, Smyser CD, Sokol GM, Merhar S, Schreiber MD, Glass HC, Heagerty PJ, Juul SE. Trial of Erythropoietin for Hypoxic-Ischemic Encephalopathy in Newborns. N Engl J Med. 2022 07 14; 387(2):148-159. PMID: 35830641.

    Read at: PubMed

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