Karl J. Karlson, MD

Emeritus Assistant Professor, Surgery

Karl Karlson
88 E. Newton St Newton Pavilion


As a clinical cardiac surgeon, I am frequently confronted with the problems of revascularization of the ischemic heart. Coronary artery bypass grafting is often employed to deliver new blood supply to the myocardium, but occasionally the anastomoses fail because of the development of neointimal hyperplasia and fibrosis where vessel connections are constructed. Using nanotechnology to deliver agents to the site of the anastomoses could be a game changer in terms of graft patency.

Transmyocardial laser revascularization of the heart has been shown to trigger neovascularization in underperfused regions of the myocardium not amenable to standard revascularization. The prospect of using nanotechnology to deliver growth factor or other agents in a targeted fashion to the area of the laser channels may help to achieve a quantum increase in the benefit realized from the laser surgery.

Other Positions

  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
  • Chief, Cardiac Surgery, Boston Medical Center


  • Brown University School of Medicine, MD
  • Brown University, MMS
  • Brown University, AB


  • Published on 1/29/2024

    Dobrilovic N, Karlson K, Raman J, Soukas P, Sadiq I, Vognar L, Singh A. Left Bronchial Compression After Endovascular Repair of Contained Rupture of Descending Thoracic Aortic Dissection. Innovations (Phila). 2024; 19(1):92-93. PMID: 38284402.

    Read at: PubMed
  • Published on 4/29/2023

    Wang Y, Yin K, Datar Y, Mohnot J, Nodoushani AY, Zhan Y, Karlson KJ, Edwards NM, Reardon MJ, Dobrilovic N. Aortic Dissection During Pregnancy and Puerperium: Contemporary Incidence and Outcomes in the United States. J Am Heart Assoc. 2023 May 02; 12(9):e028436. PMID: 37119066.

    Read at: PubMed
  • Published on 11/1/2022

    Nodoushani AY, Wang Y, Datar Y, Mohnot J, Karlson KJ, Edwards NM, Yin K, Dobrilovic N. Association of Intravenous Drug Use and Length of Stay Following Infective Endocarditis. J Surg Res. 2023 Feb; 282:239-245. PMID: 36332302.

    Read at: PubMed
  • Published on 5/18/2022

    Datar Y, Yin K, Wang Y, Lawrence KW, Awtry EH, Cervantes-Arslanian AM, Kimmel SD, Fagan MA, Weinstein ZM, Karlson KJ, McAneny DB, Edwards NM, Dobrilovic N. Surgical outcomes of pulmonary valve infective endocarditis: A US population-based analysis. Int J Cardiol. 2022 Aug 15; 361:50-54. PMID: 35597492.

    Read at: PubMed
  • Published on 2/10/2022

    Lawrence KW, Yin K, Connelly HL, Datar Y, Brydges H, Balasubramaniyan R, Karlson KJ, Edwards NM, Dobrilovic N. Sex-based outcomes in surgical repair of acute type A aortic dissection: A meta-analysis and meta-regression. J Thorac Cardiovasc Surg. 2024 Jan; 167(1):76-85.e13. PMID: 35331557.

    Read at: PubMed
  • Published on 7/25/2021

    Brydges H, Yin K, Balasubramaniyan R, Lawrence KW, Luo R, Karlson KJ, McAneny DB, Edwards NM, Reardon MJ, Dobrilovic N. Primary Pericardial Mesothelioma: A Population-Based Propensity Score-Matched Analysis. Semin Thorac Cardiovasc Surg. 2022 Autumn; 34(3):1113-1119. PMID: 34320396.

    Read at: PubMed
  • Published on 12/22/2020

    Yin K, March RJ, Hoopes CW, Balk RA, Raman J, Lateef OB, Tiwari A, Bak E, Karlson KJ, Edwards NM, Dobrilovic N. Extracorporeal membrane oxygenation in the management of granulomatosis with polyangiitis. J Card Surg. 2021 Feb; 36(2):743-747. PMID: 33350513.

    Read at: PubMed
  • Published on 10/7/2020

    Yin K, Brydges H, Lawrence KW, Wei Y, Karlson KJ, McAneny DB, Edwards NM, Reardon MJ, Dobrilovic N. Primary cardiac lymphoma. J Thorac Cardiovasc Surg. 2022 Aug; 164(2):573-580.e1. PMID: 33158567.

    Read at: PubMed
  • Published on 1/23/2020

    Yin K, Luo R, Wei Y, Wang F, Zhang Y, Karlson KJ, Zhang Z, Reardon MJ, Dobrilovic N. Survival outcomes in patients with primary cardiac sarcoma in the United States. J Thorac Cardiovasc Surg. 2021 07; 162(1):107-115.e2. PMID: 32111430.

    Read at: PubMed
  • Published on 7/2/2014

    Lazar HL, Ketchedjian A, Haime M, Karlson K, Cabral H. Topical vancomycin in combination with perioperative antibiotics and tight glycemic control helps to eliminate sternal wound infections. J Thorac Cardiovasc Surg. 2014 Sep; 148(3):1035-8; 1038-40. PMID: 25129595.

    Read at: PubMed

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