As a clinical cardiac surgeon, I am frequently confronted with the problems of revascularization of the ischemic heart. Coronary artery bypass grafting is often employed to deliver new blood supply to the myocardium, but occasionally the anastomoses fail because of the development of neointimal hyperplasia and fibrosis where vessel connections are constructed. Using nanotechnology to deliver agents to the site of the anastomoses could be a game changer in terms of graft patency.
Transmyocardial laser revascularization of the heart has been shown to trigger neovascularization in underperfused regions of the myocardium not amenable to standard revascularization. The prospect of using nanotechnology to deliver growth factor or other agents in a targeted fashion to the area of the laser channels may help to achieve a quantum increase in the benefit realized from the laser surgery.
- Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
- Chief, Cardiac Surgery, Boston Medical Center
- Brown University School of Medicine, MD
- Brown University, MMS
- Brown University, AB
- Published on 4/29/2023
Wang Y, Yin K, Datar Y, Mohnot J, Nodoushani AY, Zhan Y, Karlson KJ, Edwards NM, Reardon MJ, Dobrilovic N. Aortic Dissection During Pregnancy and Puerperium: Contemporary Incidence and Outcomes in the United States. J Am Heart Assoc. 2023 May 02; 12(9):e028436. PMID: 37119066.
- Published on 11/1/2022
Nodoushani AY, Wang Y, Datar Y, Mohnot J, Karlson KJ, Edwards NM, Yin K, Dobrilovic N. Association of Intravenous Drug Use and Length of Stay Following Infective Endocarditis. J Surg Res. 2023 Feb; 282:239-245. PMID: 36332302.
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Datar Y, Yin K, Wang Y, Lawrence KW, Awtry EH, Cervantes-Arslanian AM, Kimmel SD, Fagan MA, Weinstein ZM, Karlson KJ, McAneny DB, Edwards NM, Dobrilovic N. Surgical outcomes of pulmonary valve infective endocarditis: A US population-based analysis. Int J Cardiol. 2022 Aug 15; 361:50-54. PMID: 35597492.
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Lawrence KW, Yin K, Connelly HL, Datar Y, Brydges H, Balasubramaniyan R, Karlson KJ, Edwards NM, Dobrilovic N. Sex-based outcomes in surgical repair of acute type A aortic dissection: A meta-analysis and meta-regression. J Thorac Cardiovasc Surg. 2022 Feb 10. PMID: 35331557.
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Brydges H, Yin K, Balasubramaniyan R, Lawrence KW, Luo R, Karlson KJ, McAneny DB, Edwards NM, Reardon MJ, Dobrilovic N. Primary Pericardial Mesothelioma: A Population-Based Propensity Score-Matched Analysis. Semin Thorac Cardiovasc Surg. 2022 Autumn; 34(3):1113-1119. PMID: 34320396.
- Published on 12/22/2020
Yin K, March RJ, Hoopes CW, Balk RA, Raman J, Lateef OB, Tiwari A, Bak E, Karlson KJ, Edwards NM, Dobrilovic N. Extracorporeal membrane oxygenation in the management of granulomatosis with polyangiitis. J Card Surg. 2021 Feb; 36(2):743-747. PMID: 33350513.
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Yin K, Brydges H, Lawrence KW, Wei Y, Karlson KJ, McAneny DB, Edwards NM, Reardon MJ, Dobrilovic N. Primary cardiac lymphoma. J Thorac Cardiovasc Surg. 2022 Aug; 164(2):573-580.e1. PMID: 33158567.
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Yin K, Luo R, Wei Y, Wang F, Zhang Y, Karlson KJ, Zhang Z, Reardon MJ, Dobrilovic N. Survival outcomes in patients with primary cardiac sarcoma in the United States. J Thorac Cardiovasc Surg. 2021 07; 162(1):107-115.e2. PMID: 32111430.
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Lazar HL, Ketchedjian A, Haime M, Karlson K, Cabral H. Topical vancomycin in combination with perioperative antibiotics and tight glycemic control helps to eliminate sternal wound infections. J Thorac Cardiovasc Surg. 2014 Sep; 148(3):1035-8; 1038-40. PMID: 25129595.
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