Joseph M. Keane, MD

Adjunct Assistant Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Joseph Keane is a Consultant Respiratory Physician in St. James’s Hospital, and Associate Professor of Medicine in Trinity College. He completed a clinical and research post-doctoral fellowship in Pulmonary and Critical Care Medicine at Chobanian and Avedisian School of Medicine.

Prof Keane’s research interests include the host immune response to tuberculosis; and developing improved diagnostic tests for this disease. His NEJM article on the association of TB reactivation and the use of TNF blockers is the most cited tuberculosis paper of the last 10 years. He is the director of the TB service in St. James’s Hospital, which is the designated supra-regional center for tuberculosis.

The Health Research Board, Science Foundation Ireland, and the Royal City of Dublin Hospital Trust fund Prof Keane’s research.

Prof Keane was the recipient of the Inaugural William Stokes Award in September 2011 in recognition of his research activities.

Publications

  • Published 8/16/2021

    O'Leary S, Bahlool AZ, O'Connor G, Cryan SA, Keane JM, O'Sullivan MP. An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis. J Vis Exp. 2021 08 16; (174). PMID: 34459817.

    Read at: PubMed

  • Published 10/29/2018

    O'Connor G, Krishnan N, Fagan-Murphy A, Cassidy J, O'Leary S, Robertson BD, Keane J, O'Sullivan MP, Cryan SA. Inhalable poly(lactic-co-glycolic acid) (PLGA) microparticles encapsulating all-trans-Retinoic acid (ATRA) as a host-directed, adjunctive treatment for Mycobacterium tuberculosis infection. Eur J Pharm Biopharm. 2019 Jan; 134:153-165. PMID: 30385419.

    Read at: PubMed

  • Published 2/12/2018

    Dockry É, O'Leary S, Gleeson LE, Lyons J, Keane J, Gray SG, Doherty DG. Epigenetic induction of CD1d expression primes lung cancer cells for killing by invariant natural killer T cells. Oncoimmunology. 2018; 7(6):e1428156. PMID: 29872551.

    Read at: PubMed

  • Published 1/15/2017

    Lewinsohn DM, Leonard MK, LoBue PA, Cohn DL, Daley CL, Desmond E, Keane J, Lewinsohn DA, Loeffler AM, Mazurek GH, O'Brien RJ, Pai M, Richeldi L, Salfinger M, Shinnick TM, Sterling TR, Warshauer DM, Woods GL. Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children. Clin Infect Dis. 2017 Jan 15; 64(2):111-115. PMID: 28052967.

    Read at: PubMed

  • Published 12/8/2016

    Lewinsohn DM, Leonard MK, LoBue PA, Cohn DL, Daley CL, Desmond E, Keane J, Lewinsohn DA, Loeffler AM, Mazurek GH, O'Brien RJ, Pai M, Richeldi L, Salfinger M, Shinnick TM, Sterling TR, Warshauer DM, Woods GL. Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children. Clin Infect Dis. 2017 Jan 15; 64(2):e1-e33. PMID: 27932390.

    Read at: PubMed

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Websites

Education

  • Trinity College, MBBCh
  • Trinity College, DM
  • Trinity College, BA

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