Joseph Kaserman, MD

Assistant Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Dr. Kaserman is an Assistant Professor of Medicine at the Chobanian and Avedisian School of Medicine and a member of the Pulmonary, Allergy, Sleep and Critical Care Medicine section as well as a researcher in the Wilson Lab at the Center for Regenerative Medicine of Boston University and Boston Medical Center. His research has focused on studying the biological underpinnings of the genetic disease alpha-1 antitrypsin deficiency using pluripotent stem cell models combined with gene editing technology in order to rationally develop potential future disease modifying and curative therapies.

Publications

  • Published 4/8/2026

    Hersh CP, Teckman JH, Strnad P, Hakim A, Carroll TP, Hall IP, Ghosh AJ, Barjaktarevic I, McElvaney NG, Kaserman JE, Lomas DA, Strange C, Drummond MB, Rennard S, Hanna KE, Clark VC, Goldklang MP, Iverson P, Wilson AA. Z variant heterozygosity in alpha-1 antitrypsin deficiency: disease risk and treatment implications. Orphanet J Rare Dis. 2026 Apr 08; 21(1). PMID: 41952152.

    Read at: PubMed

  • Published 10/29/2024

    Soares De Oliveira L, Kaserman JE, Van Der Spek AH, Lee NJ, Undeutsch HJ, Werder RB, Wilson AA, Hollenberg AN. Thyroid hormone receptor beta (THRß1) is the major regulator of T3 action in human iPSC-derived hepatocytes. Mol Metab. 2024 Dec; 90:102057. PMID: 39481850.

    Read at: PubMed

  • Published 10/1/2024

    Hu Y, Soares De Oliveira L, Falize K, Paul van Trotsenburg AS, Fliers E, Kaserman JE, Wilson AA, Hollenberg AN, Bruinstroop E, Boelen A. Disturbed function of TBL1X has a differential effect on T3-regulated gene expression in two human liver cell models. Eur Thyroid J. 2024 Oct 01; 13(5). PMID: 39316725.

    Read at: PubMed

  • Published 12/6/2022

    Kaserman JE, Werder RB, Wang F, Matte T, Higgins MI, Dodge M, Lindstrom-Vautrin J, Bawa P, Hinds A, Bullitt E, Caballero IS, Shi X, Gerszten RE, Brunetti-Pierri N, Liesa M, Villacorta-Martin C, Hollenberg AN, Kotton DN, Wilson AA. Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity. Cell Rep. 2022 Dec 06; 41(10):111775. PMID: 36476855.

    Read at: PubMed

  • Published 9/8/2022

    Scoon WA, Mancio-Silva L, Suder EL, Villacorta-Martin C, Lindstrom-Vautrin J, Bernbaum JG, Mazur S, Johnson RF, Olejnik J, Flores EY, Mithal A, Wang F, Hume AJ, Kaserman JE, March-Riera S, Wilson AA, Bhatia SN, Mühlberger E, Mostoslavsky G. Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes. Stem Cell Reports. 2022 Oct 11; 17(10):2286-2302. PMID: 36084636.

    Read at: PubMed

View All 13 Publications:   View Full Profile in BUMC

Other Positions

  • Member, Pulmonary Center
    Boston University
  • Member, Center for Regenerative Medicine
    Boston University

Websites

Education

  • University of Vermont College of Medicine, MD
  • Cornell University, BS

View all profiles