Jessica L. Fetterman, PhD
Assistant Professor, Medicine
Biography
Jessica L. Fetterman, PhD, FAHA is a basic and translational scientist studying the intersections of mitochondrial physiology, mitochondrial genetic epidemiology, and cardiovascular disease. Her work focuses on the contribution of mitochondrial genetic variation and abnormalities to cardiovascular disease in the presence of risk factors, including tobacco product use and diabetes.
Using bioinformatics methods, Dr. Fetterman discovered that several select mitochondrial genetic variants are associated with non-invasive measures of vascular function within the Framingham Heart Study (FHS). Additionally, she has applied similar methodology to select mitochondrial single variant data within Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) to determine the associations of select mitochondrial genetic variants with cardiometabolic measures in collaboration with members of the mitochondrial genetics working group. Recently, Dr. Fetterman was awarded the competitive Trans-Omics Precision Medicine (TOPMed) Analytical Support Award for early career investigators to perform comprehensive bioinformatic annotation of the mitochondrial genetic variants within the TOPMed cohorts.
Dr. Fetterman also conducts research on the impact of new and emerging tobacco products on the vasculature, particularly studies designed to inform tobacco product regulation. Some of her recent work demonstrated that tobacco product flavoring additives induce vascular endothelial dysfunction, an early indicator of cardiovascular injury. She serves as an Associate Director of Education and Training within American Heart Association Tobacco Regulation and Addiction Center. Additionally, she is the Director for the Boston University Tobacco Regulatory Science Affinity Research Collaborative, which is designed to bring together multi-disciplinary teams of scientists within Boston University to increase our understanding of tobacco product use patterns and the impact of new and emerging tobacco products on human health and disease.
Other Positions
- Investigator, Framingham Heart Study
- Member, Whitaker Cardiovascular Institute, Boston University
- Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
Education
- University of Alabama at Birmingham, PhD
- Ohio Wesleyan University, BA
Publications
- Published on 2/6/2025
Jebai R, Hong T, Ranker LR, Wu J, Rohila A, Fetterman JL, Cornacchione Ross J. Social Media Engagement and Quit Intentions among Youth with Exclusive E-cigarette Use: The Moderating Role of Social Norms. Nicotine Tob Res. 2025 Feb 06. PMID: 39912206.
Read at: PubMed - Published on 2/5/2025
Cooper LL, Majid S, Wang N, Fetterman JL, Palmisano JN, Benjamin EJ, Vasan RS, Mitchell GF, Hamburg NM. Cross-sectional and longitudinal associations of smoking behaviour with central arterial haemodynamic measures: the Framingham Heart Study. Eur J Prev Cardiol. 2025 Feb 05. PMID: 39907713.
Read at: PubMed - Published on 1/14/2025
Moreira-Bouchard JD, Roberts LM, Silva V, Nessen EJ, Smith KK, Streed CG, Fetterman JL. Enhancing student understanding of cardiovascular disease burden in marginalized communities in the physiology classroom. Adv Physiol Educ. 2025 Mar 01; 49(1):230-239. PMID: 39809469.
Read at: PubMed - Published on 12/15/2024
Pinheiro A, Petty CA, Stephens CE, Cabrera K, Palanques-Tost E, Gower AC, Marano M, Leviss EM, Boberg MJ, Mahendran J, Bock PM, Fetterman JL, Naya FJ. The Dlk1-Dio3 noncoding RNA cluster coordinately regulates mitochondrial respiration and chromatin structure to establish proper cell state for muscle differentiation. Development. 2024 Dec 15; 151(24). PMID: 39612212.
Read at: PubMed - Published on 12/3/2024
Dennison Himmelfarb CR, Benowitz NL, Blank MD, Bhatnagar A, Chase PJ, Davis EM, Fetterman JL, Keller-Hamilton B, Ogungbe O, Page RL, Rezk-Hanna M, Robertson RM, Whitsel LP. Impact of Smokeless Oral Nicotine Products on Cardiovascular Disease: Implications for Policy, Prevention, and Treatment: A Policy Statement From the American Heart Association. Circulation. 2025 Jan 07; 151(1):e1-e21. PMID: 39624904.
Read at: PubMed - Published on 11/29/2024
Wu J, Ranker LR, Origgi JM, Ma J, Hao D, Benjamin EJ, Cornacchione Ross J, Xuan Z, Wijaya D, Fetterman JL, Hong T. Protecting historically marginalized groups or targeted marketing? A computational analysis of individuals engaging with public and protected cigar-branded tweets. Drug Alcohol Depend. 2025 Jan 01; 266:112516. PMID: 39689499.
Read at: PubMed - Published on 11/12/2024
Ranker LR, Tofu DA, Lu M, Wu J, Bhatnagar A, Robertson RM, Wijaya D, Hong T, Fetterman JL, Xuan Z. Concurrent Mentions of Vaping and Alcohol on Twitter: Latent Dirichlet Analysis. J Med Internet Res. 2024 Nov 12; 26:e51870. PMID: 39531640.
Read at: PubMed - Published on 11/1/2024
Moreira-Bouchard JD, Cunha J, Tao BS, Kim H, Lepson J, Nessen EJ, Milstone ZJ, Fisher N, Clinton N, Roberts LM, Serrano MA, Gopal DM, Benjamin EJ, So-Armah K, Fetterman JL. Creating diversity, equity, inclusion, and accessibility statements for your CV: a resource guide to effectiveness and comprehensiveness. Am J Physiol Heart Circ Physiol. 2024 Dec 01; 327(6):H1376-H1383. PMID: 39485298.
Read at: PubMed - Published on 10/16/2024
Eckhardt CM, Balte P, Morris JE, Bhatt SP, Couper D, Fetterman J, Freedman N, Jacobs DR, Hou L, Kalhan R, Liu Y, Loehr L, Lutsey PL, Schwartz JE, White W, Yende S, London SJ, Sanchez TR, Oelsner EC. Non-cigarette tobacco products, aryl-hydrocarbon receptor repressor gene methylation and smoking-related health outcomes. Thorax. 2024 Oct 16; 79(11):1060-1068. PMID: 39033027.
Read at: PubMed - Published on 10/4/2024
Wu J, Fetterman JL, Cornacchione Ross J, Hong T. Effects of Message Frames and Sources in TikTok Videos for Youth Vaping Cessation: Emotions and Perceived Message Effectiveness as Mediating Mechanisms. J Adolesc Health. 2025 Jan; 76(1):122-130. PMID: 39365229.
Read at: PubMed
View 63 more publications: View full profile at BUMC