Cancer Research: Dr. Feng is Director of the Laboratory of Zebrafish Genetics and Cancer Therapeutics. Dr. Feng’s research interests focus on identifying novel genes and pathways that are essential for MYC-related tumor transformation and progression, particularly for T-Lymphoblastic Lymphoma/Leukemia, Neuroblastoma and Breast Cancer. The research strategy of Dr. Feng’s research is to combine the analysis of human cancer cells with the genetic and imaging capacities of the zebrafish system.
Current research areas in Dr. Feng’s laboratory include:
1) To determine the molecular mechanisms underlying tumor cell intravasation and tumor progression.
2) To identify novel genes and pathways that, when mutated, delay the initiation and progression of MYC-related cancers.
3) To test the identified genes’ therapeutic potential in treating MYC-related cancers and to characterize their molecular relevance to MYC.
The long-term goal of Dr. Feng’s research is to discover novel molecular therapies to target critical components of MYC-driven oncogenic pathways, thus providing treatment alternatives that are more specific and less toxic.
- Member, BU-BMC Cancer Center, Boston University
- Member, Genome Science Institute, Boston University
- Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
- Beijing Medical University, MD
- University of Georgia, PhD
- Peking Union Medical College, MS
- GMS FC 715
- GMS IMP 730
- GMS MM 703
- GMS PM 932
- Published on 3/23/2023
Laroche FJF, Li S, Shen N, Hwang SK, Nguyen G, Yu W, Wong CK, Quinton RJ, Berman JN, Liu CT, Singh A, Ganem NJ, Thiagalingam S, Feng H. S1P1 Threonine 236 Phosphorylation Mediates the Invasiveness of Triple-Negative Breast Cancer and Sensitivity to FTY720. Cells. 2023 Mar 23; 12(7). PMID: 37048053.
- Published on 6/16/2022
Wang Y, Shen N, Spurlin G, Korm S, Huang S, Anderson NM, Huiting LN, Liu H, Feng H. a-Ketoglutarate-Mediated DNA Demethylation Sustains T-Acute Lymphoblastic Leukemia upon TCA Cycle Targeting. Cancers (Basel). 2022 Jun 16; 14(12). PMID: 35740646.
- Published on 2/8/2022
Kemet C, Hill E, Feng H. Fishing for drugs. Elife. 2022 02 08; 11. PMID: 35133278.
- Published on 11/16/2021
Shen N, Korm S, Karantanos T, Li D, Zhang X, Ritou E, Xu H, Lam A, English J, Zong WX, Liu CT, Shirihai O, Feng H. DLST-dependence dictates metabolic heterogeneity in TCA-cycle usage among triple-negative breast cancer. Commun Biol. 2021 11 16; 4(1):1289. PMID: 34785772.
- Published on 8/2/2021
Friedlander JE, Shen N, Zeng A, Korm S, Feng H. Failure to Guard: Mitochondrial Protein Quality Control in Cancer. Int J Mol Sci. 2021 Aug 02; 22(15). PMID: 34361072.
- Published on 7/7/2021
Anderson NM, Qin X, Finan JM, Lam A, Athoe J, Missiaen R, Skuli N, Kennedy A, Saini AS, Tao T, Zhu S, Nissim I, Look AT, Qing G, Simon MC, Feng H. Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma. Cancer Res. 2021 Sep 01; 81(17):4417-4430. PMID: 34233924.
- Published on 5/20/2021
Miao KZ, Kim GY, Meara GK, Qin X, Feng H. Tipping the Scales With Zebrafish to Understand Adaptive Tumor Immunity. Front Cell Dev Biol. 2021; 9:660969. PMID: 34095125.
- Published on 5/1/2021
Zhou Y, Lian H, Shen N, Korm S, Kwok Ping Lam A, Layton O, Huiting LN, Li D, Miao K, Zeng A, Landesman-Bollag E, Seldin DC, Fu H, Hong L, Feng H. The multifaceted role of protein kinase CK2 in high-risk acute lymphoblastic leukemia. Haematologica. 2021 05 01; 106(5):1461-1465. PMID: 32817283.
- Published on 3/1/2021
Shao W, Kilic K, Yin W, Wirak G, Qin X, Feng H, Boas D, Gabel CV, Yi J. Wide field-of-view volumetric imaging by a mesoscopic scanning oblique plane microscopy with switchable objective lenses. Quant Imaging Med Surg. 2021 Mar; 11(3):983-997. PMID: 33654671.
- Published on 7/7/2020
Qin X, Denton WD, Huiting LN, Smith KS, Feng H. Unraveling the regulatory role of endoplasmic-reticulum-associated degradation in tumor immunity. Crit Rev Biochem Mol Biol. 2020 08; 55(4):322-353. PMID: 32633575.
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