Haiyan Gong, MD, PhD
Professor, Ophthalmology
Biography
Glaucoma is a leading cause of blindness worldwide. A primary risk factor for the development and progression of primary open-angle glaucoma (POAG) is elevation of intraocular pressure (IOP), which resulted from increased aqueous outflow resistance. However, the cause of this elevated aqueous outflow resistance in POAG remains unknown. The research in our laboratory is focused on understanding the mechanisms that regulate aqueous humor outflow resistance in normal eyes and how this resistance is increased in POAG in order to provide new insights for developing new therapeutic strategies to lower IOP.
Other Positions
- Professor, Anatomy & Neurobiology, Boston University Chobanian & Avedisian School of Medicine
- Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
Education
- Nanchang University, MD
- Boston University School of Medicine, PhD
- Peking Union Medical College, MS
Publications
- Published on 8/7/2022
Sosnowik S, Swain DL, Liu N, Fan S, Toris CB, Gong H. Endothelial Glycocalyx Morphology in Different Flow Regions of the Aqueous Outflow Pathway of Normal and Laser-Induced Glaucoma Monkey Eyes,. Cells. 2022; 15(11):2452.
Read at: Custom - Published on 3/10/2022
Sosnowik S, Swain DL, Fan S, Toris CB, Gong H. Morphological changes to Schlemm's canal and the distal aqueous outflow pathway in monkey eyes with laser-induced ocular hypertension. Exp Eye Res. 2022 Jun; 219:109030. PMID: 35283108.
Read at: PubMed - Published on 2/1/2022
McDowell CM, Kizhatil K, Elliott MH, Overby DR, van Batenburg-Sherwood J, Millar JC, Kuehn MH, Zode G, Acott TS, Anderson MG, Bhattacharya SK, Bertrand JA, Borras T, Bovenkamp DE, Cheng L, Danias J, De Ieso ML, Du Y, Faralli JA, Fuchshofer R, Ganapathy PS, Gong H, Herberg S, Hernandez H, Humphries P, John SWM, Kaufman PL, Keller KE, Kelley MJ, Kelly RA, Krizaj D, Kumar A, Leonard BC, Lieberman RL, Liton P, Liu Y, Liu KC, Lopez NN, Mao W, Mavlyutov T, McDonnell F, McLellan GJ, Mzyk P, Nartey A, Pasquale LR, Patel GC, Pattabiraman PP, Peters DM, Raghunathan V, Rao PV, Rayana N, Raychaudhuri U, Reina-Torres E, Ren R, Rhee D, Chowdhury UR, Samples JR, Samples EG, Sharif N, Schuman JS, Sheffield VC, Stevenson CH, Soundararajan A, Subramanian P, Sugali CK, Sun Y, Toris CB, Torrejon KY, Vahabikashi A, Vranka JA, Wang T, Willoughby CE, Xin C, Yun H, Zhang HF, Fautsch MP, Tamm ER, Clark AF, Ethier CR, Stamer WD. Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms. Invest Ophthalmol Vis Sci. 2022 02 01; 63(2):12. PMID: 35129590.
Read at: PubMed - Published on 1/13/2022
Ren R, Humphrey AA, Swain DL, Gong H. Relationships between Intraocular Pressure, Effective Filtration Area, and Morphological Changes in the Trabecular Meshwork of Steroid-Induced Ocular Hypertensive Mouse Eyes. Int J Mol Sci. 2022 Jan 13; 23(2). PMID: 35055036.
Read at: PubMed - Published on 1/1/2022
Freddo TF, Civan M and Gong H. Albert and Jakobiec's Principles and Practices of Ophthalmology. Aqueous humor and the dynamics of its flow: Mechanisms and routes of aqueous humor drainage. Springer. 2022; 1989-2032.
- Published on 7/7/2021
Vincent MP, Stack T, Vahabikashi A, Li G, Perkumas KM, Ren R, Gong H, Stamer WD, Johnson M, Scott EA. Surface Engineering of FLT4-Targeted Nanocarriers Enhances Cell-Softening Glaucoma Therapy. ACS Appl Mater Interfaces. 2021 Jul 21; 13(28):32823-32836. PMID: 34232612.
Read at: PubMed - Published on 2/9/2021
Swain DL, Le TD, Yasmin S, Fernandes B, Lamaj G, Dasgupta I, Gao Y, Gong H. Morphological factors associated with giant vacuoles with I-pores in Schlemm's canal endothelial cells of human eyes: A serial block-face scanning electron microscopy study. Exp Eye Res. 2021 04; 205:108488. PMID: 33571532.
Read at: PubMed - Published on 12/28/2020
Nettesheim A, Shim MS, Dixon A, Raychaudhuri U, Gong H, Liton PB. Cathepsin B Localizes in the Caveolae and Participates in the Proteolytic Cascade in Trabecular Meshwork Cells. Potential New Drug Target for the Treatment of Glaucoma. J Clin Med. 2020 Dec 28; 10(1). PMID: 33379277.
Read at: PubMed - Published on 1/1/2020
Gong H and Swain DL. Current Developments in Glaucoma Surgery and MIGS. Anatomy of the conventional aqueous outflow pathway. Kugler. 2020; 1-37.
- Published on 12/5/2019
Vahabikashi A, Gelman A, Dong B, Gong L, Cha EDK, Schimmel M, Tamm ER, Perkumas K, Stamer WD, Sun C, Zhang HF, Gong H, Johnson M. Increased stiffness and flow resistance of the inner wall of Schlemm's canal in glaucomatous human eyes. Proc Natl Acad Sci U S A. 2019 Dec 26; 116(52):26555-26563. PMID: 31806762.
Read at: PubMed
View 69 more publications: View full profile at BUMC