George T. O’Connor, MD
Professor, Medicine
Biography
My research focuses on epidemiology, including genetic epidemiology, and clinical investigations of asthma, allergy, chronic obstructive pulmonary disease, and sleep apnea. I am currently a multiple PI and Co-director of the NHLBI’s Framingham Heart Study, and I am a co-investigator in the Risk Underlying Rural Areas Longitudinal (RURAL) Cohort Study. I am the Boston University-Boston Medical Center principal investigator of multiple NIH-funded multi-center investigations, including the All of Us Research Program, the Childhood Asthma in Urban Settings (CAUSE) consortium, and the Vitamin D Antenatal Asthma Reduction Trial (VDAART. I have led the BU-BMC site of clinical trials in children and adolescents with asthma and the Urban Environment and Childhood Asthma (URECA) birth-cohort study examining the risk factors for asthma and allergy in urban settings. l conduct epidemiologic and genetic epidemiologic research at the Framingham Heart Study, including genome-wide association studies seeking novel genetic determinants of lung function impairment, interstitial lung abnormalities, and atopy. My research spans disciplines including adult medicine, pediatrics, epidemiology, genetics and genomics, immunology, and environmental science. At Boston Medical Center, my outpatient practice focuses on adults with asthma, COPD, and bronchiectasis. I am an Associate Editor of JAMA.
Other Positions
- Ad-interim Director; Co-Principle Investigator, Framingham Heart Study
- Member, Pulmonary Center, Boston University
- Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
- Member, Genome Science Institute, Boston University
Education
- Boston University School of Medicine, MD
- Harvard School of Public Health, MS
- Boston University, BA
Publications
- Published on 6/1/2024
Kearney CM, Sangani R, Shankar D, O'Connor GT, Law AC, Walkey AJ, Bosch NA. Comparative Effectiveness of Mepolizumab, Benralizumab, and Dupilumab among Patients with Difficult-to-Control Asthma: A Multicenter Retrospective Propensity-matched Analysis. Ann Am Thorac Soc. 2024 Jun; 21(6):866-874. PMID: 38241013.
Read at: PubMed - Published on 5/21/2024
Fulkerson PC, Lussier SJ, Bendixsen CG, Castina SM, Gebretsadik T, Marlin JS, Russell PB, Seibold MA, Everman JL, Moore CM, Snyder BM, Thompson K, Tregoning GS, Wellford S, Arbes SJ, Bacharier LB, Calatroni A, Camargo CA, Dupont WD, Furuta GT, Gruchalla RS, Gupta RS, Hershey GK, Jackson DJ, Johnson CC, Kattan M, Liu AH, Murrison L, O'Connor GT, Phipatanakul W, Rivera-Spoljaric K, Rothenberg ME, Seroogy CM, Teach SJ, Zoratti EM, Togias A, Hartert TV, Heros Study Team OBOT. Human Epidemiology and RespOnse to SARS-CoV-2 (HEROS): Objectives, Design and Enrollment Results of a 12-City Remote Observational Surveillance Study of Households with Children using Direct-to-Participant Methods. Am J Epidemiol. 2024 May 21. PMID: 38775275.
Read at: PubMed - Published on 5/16/2024
Abdalla M, Elalami R, Cho MH, O'Connor GT, Rice M, Horowitz M, Akhoundi N, Yen A, Kalhan R, Diaz AA. Airway Mucus Plugs in Community-Living Adults: A Study Protocol. medRxiv. 2024 May 16. PMID: 38798504.
Read at: PubMed - Published on 4/2/2024
Konno-Yamamoto A, Goswamy V, Calatroni A, Gergen PJ, Johnson M, Sorkness RL, Bacharier LB, O'Connor GT, Kattan M, Wood RA, Gagalis L, Visness CM, Gern JE. Relationships between lung function, allergy, and wheezing in urban children. J Allergy Clin Immunol. 2024 Apr 02. PMID: 38574825.
Read at: PubMed - Published on 3/12/2024
Zhang J, Moll M, Hobbs BD, Bakke P, Regan EA, Xu H, Dupuis J, Chiles JW, McDonald MN, Divo MJ, Silverman EK, Celli BR, O'Connor GT, Cho MH. Genetically Predicted Body Mass Index and Mortality in COPD. Am J Respir Crit Care Med. 2024 Mar 12. PMID: 38471013.
Read at: PubMed - Published on 3/12/2024
Seo J, Gaddis NC, Patchen BK, Xu J, Barr RG, O'Connor G, Manichaikul AW, Gharib SA, Dupuis J, North KE, Cassano PA, Hancock DB. Exploiting meta-analysis of genome-wide interaction with serum 25-hydroxyvitamin D to identify novel genetic loci associated with pulmonary function. Am J Clin Nutr. 2024 May; 119(5):1227-1237. PMID: 38484975.
Read at: PubMed - Published on 2/27/2024
McCauley KE, Durack J, Lynch KV, Fadrosh DW, Fujimura KE, Vundla F, Özçam M, LeBeau P, Caltroni A, Burns P, Tran HT, Bacharier LB, Kattan M, O'Connor GT, Wood RA, Togias A, Boushey HA, Jackson DJ, Gern JE, Lynch SV. Early-life nasal microbiota dynamics relate to longitudinal respiratory phenotypes in urban children. J Allergy Clin Immunol. 2024 Jun; 153(6):1563-1573. PMID: 38423369.
Read at: PubMed - Published on 1/18/2024
Knihtilä HM, Stubbs BJ, Carey VJ, Laranjo N, Zeiger RS, Bacharier LB, O'Connor GT, Weiss ST, Litonjua AA. Preschool impulse oscillometry predicts active asthma and impaired lung function at school age. J Allergy Clin Immunol. 2024 Jul; 154(1):94-100.e13. PMID: 38244724.
Read at: PubMed - Published on 1/4/2024
Higbee DH, Lirio A, Hamilton F, Granell R, Wyss AB, London SJ, Bartz TM, Gharib SA, Cho MH, Wan E, Silverman E, Crapo JD, Lominchar JVT, Hansen T, Grarup N, Dantoft T, Kårhus L, Linneberg A, O'Connor GT, Dupuis J, Xu H, De Vries MM, Hu X, Rich SS, Barr RG, Manichaikul A, Wijnant SRA, Brusselle GG, Lahousse L, Li X, Hernández Cordero AI, Obeidat M, Sin DD, Harris SE, Redmond P, Taylor AM, Cox SR, Williams AT, Shrine N, John C, Guyatt AL, Hall IP, Davey Smith G, Tobin MD, Dodd JW. Genome-wide association study of preserved ratio impaired spirometry (PRISm). Eur Respir J. 2024 Jan; 63(1). PMID: 38097206.
Read at: PubMed - Published on 12/19/2023
Mebratu YA, Jones JT, Liu C, Negasi ZH, Rahman M, Rojas-Quintero J, O'Connor GT, Gao W, Dupuis J, Cho MH, Litonjua AA, Randell S, Tesfaigzi Y. Bik promotes proteasomal degradation to control low-grade inflammation. J Clin Invest. 2023 Dec 19; 134(4). PMID: 38113109.
Read at: PubMed
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