Frederick L. Ruberg, MD - Chief, Cardiovascular Medicine

Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Frederick L. Ruberg, MD is the Thomas J. Ryan Professor of Cardiovascular Medicine and Professor of Radiology at Boston University (BU) Chobanian & Avedisian School of Medicine and Chief, Section of Cardiovascular Medicine at Boston Medical Center (BMC). Dr. Ruberg attended the University of Pennsylvania Perelman School of Medicine, completed internal medicine training at Brigham and Women’s Hospital, cardiovascular disease fellowship at Boston Medical Center/Boston University School of Medicine, followed by a fellowship in cardiovascular magnetic resonance (CMR) imaging at Beth Israel Deaconess Medical Center in Boston. Committed to research mentorship, he co-directs Workforce Development for the Boston University Clinical and Translational Science Institute (CTSI) and serves as Senior Associate Editor of Circulation: Cardiovascular Imaging. Dr. Ruberg is a Fellow of the American Heart Association and a member of the Association of University Cardiologists. His clinical and research expertise primarily involves cardiac imaging and infiltrative heart disease focused on improving the recognition and care of patients with cardiac amyloidosis, particularly that owing to ATTR and the hereditary genetic TTR variant Val122Ile (or V142I). He is an investigator on numerous NIH-funded awards including co-PI of the $7.2m NHLBI-funded Screening for Cardiac Amyloidosis with Nuclear Imaging (SCAN-MP, R01 HL139671) study. An active clinical cardiologist at the BU Amyloidosis Center, he has also contributed and co-directed numerous collaborative clinical guidelines initiatives, including mostly recently the 2023 the ACC Expert Consensus Decision Pathway document on The Comprehensive Multidisciplinary Care of Patient with Cardiac Amyloidosis. Dr. Ruberg has been recognized with mentorship (2017) and citizenship (2022) awards from the BU Department of Medicine.

Publications

  • Published 5/27/2026

    Slivnick JA, Lim SC, Randazzo M, Maurer MS, Helmke S, Scherrer-Crosbie M, Vakilpour A, Zareba KM, Goyal A, Cheng R, Wakamatsu N, Kitano T, Takeuchi M, Hotta VT, Vieira MLC, Elissamburu P, Ronderos RE, Prado A, Koutroumpakis E, Deswal A, Pursnani A, Sarswat N, Addetia K, Cotella J, Ruberg FL, Frost M, Fontana M, Lam Su Ping C, Lang RM, Asch FM. Multimodal Artificial Intelligence for Cardiac Amyloidosis Diagnosis: Integrating Echocardiography With Clinical and Laboratory Data for Improved Detection. Circ Cardiovasc Imaging. 2026 May 27; e019610. PMID: 42200278.

    Read at: PubMed

  • Published 5/1/2026

    Ambardekar AV, Sarswat N, Wright R, Berk J, Davis MK, Garcia-Pavia P, Gillmore JD, Grodin JL, Mitchell JD, Mooney D, Nativi-Nicolau J, Poulsen SH, Ruberg FL, Chen C, Ji A, Siddhanti S, Tamby JF, Castaño A, Katz L, Sinha U, Fox JC, Maurer MS, Cheng RK. Acoramidis, Serum Transthyretin, and Cardiovascular Outcomes in Transthyretin Amyloid Cardiomyopathy: Insights From the ATTRibute-CM Trial. J Card Fail. 2026 May; 32(5):864-876. PMID: 42128580.

    Read at: PubMed

  • Published 4/29/2026

    McMenamin KJ, Teruya S, Slivnick J, Alreshq R, Ullah I, Fine D, Elzieny AA, Helmke S, Gallegos C, Miller EJ, Asch FM, Hasan S, Maurer MS, Ruberg FL. Fully Automated vs. Human Echocardiogram Interpretation in Transthyretin Amyloid Cardiomyopathy: The SCAN-MP Study. J Am Soc Echocardiogr. 2026 Apr 29. PMID: 42066965.

    Read at: PubMed

  • Published 2/1/2026

    Pandey S, Ruberg FL. A tale of two tracers-does one outperform the other? J Nucl Cardiol. 2026 Feb; 56:102621. PMID: 41771626.

    Read at: PubMed

  • Published 1/1/2026

    Alexander KM, Davis MK, Akinboboye O, Berk J, Bhatt K, Cappelli F, Cuddy SAM, Fontana M, Garcia-Pavia P, Gillmore JD, Griffin JM, Grodin JL, Judge DP, Khouri MG, Lam K, Masri A, Maurer MS, Obici L, Ruberg FL, Sarswat N, Shah K, Soman P, Stern L, Wright R, Xiong K, Cao X, Lystig T, Tamby JF, Castaño A, Katz L, Sinha U, Fox JC, Solomon SD, Grogan M. Efficacy of Acoramidis in Wild-Type and Variant Transthyretin Amyloid Cardiomyopathy: Results From ATTRibute-CM and Its Open-Label Extension. JAMA Cardiol. 2026 Jan 01; 11(1):57-67. PMID: 41205147.

    Read at: PubMed

View All 167 Publications:   View Full Profile in BUMC

Other Positions

  • Professor, Radiology
    Boston University Chobanian & Avedisian School of Medicine
  • Member, Whitaker Cardiovascular Institute
    Boston University
  • Member, Amyloidosis Center
    Boston University
  • Program Director, Clinical and Translational Science Institute
    Boston University Chobanian & Avedisian School of Medicine

Websites

Education

  • University of Pennsylvania School of Medicine, MD
  • Haverford College, BA

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