Frederick Lief Ruberg, MD

Professor, Medicine

Frederick Ruberg
75 E. Newton St Collamore Building


Dr. Ruberg’s clinical and research expertise is in the field of cardiac imaging including echocardiography and cardiovascular magnetic resonance imaging (CMR). Dr. Ruberg applies imaging in research designed to facilitate improved diagnosis and management of the infiltrative cardiomyopathy cardiac amyloidosis.

Other Positions

  • Professor, Radiology, Boston University Chobanian & Avedisian School of Medicine
  • Member, Whitaker Cardiovascular Institute, Boston University
  • Member, Amyloidosis Center, Boston University
  • Program Director, Pilot Translational & Clinical Studies Program, Clinical and Translational Science Institute, Boston University Chobanian & Avedisian School of Medicine


  • University of Pennsylvania School of Medicine, MD
  • Haverford College, BA


  • Published on 4/30/2024

    Datar Y, Clerc OF, Cuddy SAM, Kim S, Taylor A, Neri JC, Benz DC, Bianchi G, Yee AJ, Sanchorawala V, Ruberg FL, Landau H, Liao R, Kijewski MF, Jerosch-Herold M, Kwong RY, Di Carli MF, Falk RH, Dorbala S. Quantification of right ventricular amyloid burden with 18F-florbetapir positron emission tomography/computed tomography and its association with right ventricular dysfunction and outcomes in light-chain amyloidosis. Eur Heart J Cardiovasc Imaging. 2024 Apr 30; 25(5):687-697. PMID: 38193678.

    Read at: PubMed
  • Published on 3/16/2024

    Edwards CV, Ferri GM, Villegas-Galaviz J, Ghosh S, Bawa PS, Wang F, Klimtchuk E, Ajayi TB, Morgan GJ, Prokaeva T, Staron A, Ruberg FL, Sanchorawala V, Giadone RM, Murphy GJ. Abnormal global longitudinal strain and reduced serum inflammatory markers in cardiac AL amyloidosis patients without significant amyloid fibril deposition. bioRxiv. 2024 Mar 16. PMID: 38558967.

    Read at: PubMed
  • Published on 3/5/2024

    Ruberg FL, Maurer MS. Cardiac Amyloidosis Due to Transthyretin Protein: A Review. JAMA. 2024 Mar 05; 331(9):778-791. PMID: 38441582.

    Read at: PubMed
  • Published on 2/22/2024

    Datar Y, Cuddy SAM, Ovsak G, Giblin GT, Maurer MS, Ruberg FL, Arnaout R, Dorbala S. Myocardial Texture Analysis of Echocardiograms in Cardiac Transthyretin Amyloidosis. J Am Soc Echocardiogr. 2024 May; 37(5):570-573. PMID: 38395112.

    Read at: PubMed
  • Published on 2/20/2024

    Ruberg FL, Gropler RJ. In This Issue of the Journal. Circ Cardiovasc Imaging. 2024 Feb; 17(2):e016675. PMID: 38377239.

    Read at: PubMed
  • Published on 12/1/2023

    Chan N, Einstein AJ, Griffin JM, Rosenblum H, Teruya S, Cuomo M, De Los Santos J, DeLuca A, Johnson LL, Kinkhabwala MP, Leb JS, Mintz A, Fine D, Helmke S, Muralidhar V, Pandey S, Sabogal N, Saith SE, Winburn M, Smiley D, Miller EJ, Ruberg FL, Maurer MS. Prevalence and significance of extracardiac uptake on pyrophosphate imaging in the SCAN-MP study: the first 379 cases. J Nucl Cardiol. 2023 Dec; 30(6):2531-2539. PMID: 38245059.

    Read at: PubMed
  • Published on 10/30/2023

    Stern LK, Grodin JL, Maurer MS, Ruberg FL, Patel AR, Khouri MG, Roth LR, Aras MA, Bhardwaj A, Bhattacharya P, Brailovsky Y, Drachman BM, Ebong IA, Fine NM, Gaggin H, Gopal D, Griffin J, Judge D, Kim P, Mitchell J, Mitter SS, Mohan RC, Ramos H, Reyentovich A, Sheikh FH, Sperry B, Carter S, Urey M, Vaishnav J, Vest AR, Kittleson MM, Patel JK. The Cardiac Amyloidosis Registry Study (CARS): Rationale, Design and Methodology. J Card Fail. 2024 May; 30(5):669-678. PMID: 37907148.

    Read at: PubMed
  • Published on 10/24/2023

    Gustine JN, Staron A, Mendelson L, Joshi T, Gopal DM, Siddiqi OK, Ruberg FL, Sanchorawala V. Predictors of treatment response and survival outcomes in patients with advanced cardiac AL amyloidosis. Blood Adv. 2023 Oct 24; 7(20):6080-6091. PMID: 37581513.

    Read at: PubMed
  • Published on 10/5/2023

    Clerc OF, Cuddy SAM, Jerosch-Herold M, Benz DC, Katznelson E, Canseco Neri J, Taylor A, Kijewski MF, Bianchi G, Ruberg FL, Di Carli MF, Liao R, Kwong RY, Falk RH, Dorbala S. Myocardial Characterization for Early Diagnosis, Treatment Response Monitoring, and Risk Assessment in Systemic Light-Chain Amyloidosis. medRxiv. 2023 Oct 05. PMID: 37873250.

    Read at: PubMed
  • Published on 9/14/2023

    Clerc OF, Datar Y, Cuddy SA, Bianchi G, Taylor A, Benz DC, Robertson M, Kijewski MF, Jerosch-Herold M, Kwong RY, Ruberg FL, Liao R, Di Carli MF, Falk RH, Dorbala S. Prognostic Value of Left Ventricular 18 F-Florbetapir Uptake in Systemic Light-Chain Amyloidosis. medRxiv. 2023 Sep 14. PMID: 37745589.

    Read at: PubMed

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