Frederick L. Ruberg, MD - Chief, Cardiovascular Medicine

Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Frederick L. Ruberg, MD is the Thomas J. Ryan Professor of Cardiovascular Medicine and Professor of Radiology at Boston University (BU) Chobanian & Avedisian School of Medicine and Chief, Section of Cardiovascular Medicine at Boston Medical Center (BMC). Dr. Ruberg attended the University of Pennsylvania Perelman School of Medicine, completed internal medicine training at Brigham and Women’s Hospital, cardiovascular disease fellowship at Boston Medical Center/Boston University School of Medicine, followed by a fellowship in cardiovascular magnetic resonance (CMR) imaging at Beth Israel Deaconess Medical Center in Boston. Committed to research mentorship, he co-directs Workforce Development for the Boston University Clinical and Translational Science Institute (CTSI) and serves as Senior Associate Editor of Circulation: Cardiovascular Imaging. Dr. Ruberg is a Fellow of the American Heart Association and a member of the Association of University Cardiologists. His clinical and research expertise primarily involves cardiac imaging and infiltrative heart disease focused on improving the recognition and care of patients with cardiac amyloidosis, particularly that owing to ATTR and the hereditary genetic TTR variant Val122Ile (or V142I). He is an investigator on numerous NIH-funded awards including co-PI of the $7.2m NHLBI-funded Screening for Cardiac Amyloidosis with Nuclear Imaging (SCAN-MP, R01 HL139671) study. An active clinical cardiologist at the BU Amyloidosis Center, he has also contributed and co-directed numerous collaborative clinical guidelines initiatives, including mostly recently the 2023 the ACC Expert Consensus Decision Pathway document on The Comprehensive Multidisciplinary Care of Patient with Cardiac Amyloidosis. Dr. Ruberg has been recognized with mentorship (2017) and citizenship (2022) awards from the BU Department of Medicine.

Publications

  • Published 7/14/2026

    Berumen A, Staron A, Kalaitzidis G, Siddiqi OK, Gopal DM, Ruberg FL, Sanchorawala V. Evaluating AL-ISS within a BNP-based model for AL amyloidosis in the daratumumab era. Blood Adv. 2026 Jul 14; 10(13):4612-4616. PMID: 41995749.

    Read at: PubMed

  • Published 7/13/2026

    Pleasure M, Jackson CL, Castillo M, DeLuca A, Kinkhabwala M, Liu Q, Chernovolenko M, Ruberg FL, Elias P, Poterucha TJ, Wats K, Brailovsky Y, Maurer MS, Johnson LL, Einstein AJ. Quantitative single photon emission computed tomography/computed tomography of Tc-99m-pyrophosphate scans: metrics for short-term risk stratification in transthyretin cardiac amyloidosis. Nucl Med Commun. 2026 Jul 13. PMID: 42438950.

    Read at: PubMed

  • Published 6/1/2026

    Carey P, Barrera NI, Tersalvi G, Ansari B, Alreshq R, Davies DR, Dispenzieri A, Fine D, de Freitas C, Gallegos-Kattan C, Garmany A, Grogan M, Helmke S, Miller EJ, Pellikka PA, Scott CG, Teruya S, Ullah I, Ruberg FL, Maurer MS, AbouEzzeddine OF. Diagnostic Performance of the Mayo ATTR-CM Score in Diverse Populations: Comparison With the AMY Score. JACC Adv. 2026 Jun; 5(6 Pt 2):102843. PMID: 42312781.

    Read at: PubMed

  • Published 5/27/2026

    Slivnick JA, Lim SC, Randazzo M, Maurer MS, Helmke S, Scherrer-Crosbie M, Vakilpour A, Zareba KM, Goyal A, Cheng R, Nakamatsu N, Kitano T, Takeuchi M, Hotta VT, Campos Vieira ML, Elissamburu P, Ronderos RE, Prado A, Koutroumpakis E, Deswal A, Pursnani A, Sarswat N, Addetia K, Cotella J, Ruberg FL, Frost M, Fontana M, Lam Su Ping C, Lang RM, Asch FM. Multimodal Artificial Intelligence for Cardiac Amyloidosis Diagnosis: Integrating Echocardiography With Clinical and Laboratory Data for Improved Detection. Circ Cardiovasc Imaging. 2026 Jun; 19(6):e019610. PMID: 42200278.

    Read at: PubMed

  • Published 5/15/2026

    Tersalvi G, Tomasoni D, Coderre R, Kourelis TV, Dasgupta NR, Dispenzieri A, Flammer AJ, García-Pavía P, Gillmore JD, Grogan M, Hanna M, Maurer MS, Ruberg FL, AbouEzzeddine OF. Cardiac amyloidosis: Disease overview and novel pathophysiologic insights. J Nucl Cardiol. 2026 May; 59S:102723. PMID: 42142944.

    Read at: PubMed

View All 172 Publications:   View Full Profile in BUMC

Other Positions

  • Professor, Radiology
    Boston University Chobanian & Avedisian School of Medicine
  • Member, Whitaker Cardiovascular Institute
    Boston University
  • Member, Amyloidosis Center
    Boston University
  • Program Director, Clinical and Translational Science Institute
    Boston University Chobanian & Avedisian School of Medicine

Websites

Education

  • University of Pennsylvania School of Medicine, MD
  • Haverford College, BA

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