Frederick L. Ruberg, MD - Chief, Cardiovascular Medicine

Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Frederick L. Ruberg, MD is the Thomas J. Ryan Professor of Cardiovascular Medicine and Professor of Radiology at Boston University (BU) Chobanian & Avedisian School of Medicine and Chief, Section of Cardiovascular Medicine at Boston Medical Center (BMC). Dr. Ruberg attended the University of Pennsylvania Perelman School of Medicine, completed internal medicine training at Brigham and Women’s Hospital, cardiovascular disease fellowship at Boston Medical Center/Boston University School of Medicine, followed by a fellowship in cardiovascular magnetic resonance (CMR) imaging at Beth Israel Deaconess Medical Center in Boston. Committed to research mentorship, he co-directs Workforce Development for the Boston University Clinical and Translational Science Institute (CTSI) and serves as Senior Associate Editor of Circulation: Cardiovascular Imaging. Dr. Ruberg is a Fellow of the American Heart Association and a member of the Association of University Cardiologists. His clinical and research expertise primarily involves cardiac imaging and infiltrative heart disease focused on improving the recognition and care of patients with cardiac amyloidosis, particularly that owing to ATTR and the hereditary genetic TTR variant Val122Ile (or V142I). He is an investigator on numerous NIH-funded awards including co-PI of the $7.2m NHLBI-funded Screening for Cardiac Amyloidosis with Nuclear Imaging (SCAN-MP, R01 HL139671) study. An active clinical cardiologist at the BU Amyloidosis Center, he has also contributed and co-directed numerous collaborative clinical guidelines initiatives, including mostly recently the 2023 the ACC Expert Consensus Decision Pathway document on The Comprehensive Multidisciplinary Care of Patient with Cardiac Amyloidosis. Dr. Ruberg has been recognized with mentorship (2017) and citizenship (2022) awards from the BU Department of Medicine.

Publications

  • Published 9/4/2026

    Kourelis T, Comenzo R, Cortese A, Grodin JL, Grogan M, Milani P, Ruberg FL, Sekijima Y, Weberling LD, Kastritis E, Alexander KM. Susceptibility and screening approaches in systemic amyloidosis: expert perspectives from the International Society of Amyloidosis (ISA). Amyloid. 2026 Sep 04; 1-14. PMID: 42695486.

    Read at: PubMed

  • Published 8/30/2026

    Ruberg FL, Davis MK, Cuddy SAM, Stern LK, Akinboboye O, Shah K, Sarswat N, Khouri MG, Judge DP, Griffin JM, Grodin JL, Fawaz S, Zeldow B, Tamby JF, Castaño A, Sinha U, Fontana M, Gillmore J, Alexander KM. Long-term effects of acoramidis on mortality in variant transthyretin amyloid cardiomyopathy, including p.Val142Ile: findings from the open-label extension of ATTRibute-CM. Eur J Heart Fail. 2026 Aug 30. PMID: 42669031.

    Read at: PubMed

  • Published 8/30/2026

    Dorbala S, Maurer MS, Cuddy SAM, AbouEzzeddine OF, Di Carli MF, Dilsizian V, Dispenzieri A, Gallegos-Kattán C, Guthrie S, Mangal B, Hanna M, Khouri MG, Malhotra S, Mitchell JD, Narra RK, Orlandi C, Rosenthal JL, Ruberg FL, Smiley D, Sperry BW, Udelson JE, Weinberg RL, Wall JS, Masri A. 124I-Evuzamitide Positron Emission Tomography/Computed Tomography for Diagnosing Cardiac Amyloidosis: The REVEAL Nonrandomized Clinical Trial. JAMA. 2026 Aug 30. PMID: 42669054.

    Read at: PubMed

  • Published 8/28/2026

    Croon PM, Batinica B, Dhingra LS, Choi RB, Oikonomou EK, Shankar SV, Sangha V, van der Boon RMA, Michels M, van Ettinger M, Zwetsloot PP, Teruya S, Gallegos Kattan C, Miller EJ, Noory N, Westin OM, Fensman SK, Poulsen SH, Singh A, Balla S, Achten A, Vlachopoulos C, Antonopoulos AS, Bruining N, Gillmore JD, Maurer MS, Ruberg FL, Fontana M, Khera R. Electrocardiogram-Based Deep Learning to Prioritize Testing for Transthyretin Amyloid Cardiomyopathy. JAMA. 2026 Aug 28. PMID: 42663420.

    Read at: PubMed

  • Published 8/3/2026

    Masri A, Judge DP, Ruberg FL, Gillmore JD, Grodin JL, Obici L, Maurer MS, Fontana M, Poulsen SH, van der Meer P, Cheng RK, Cuddy SAM, Ambardekar AV, Xiong K, Cao X, Murtagh G, Siddhanti S, Castaño A, Tamby JF, Fox JC, Alexander KM, Witteles R. Plain language summary of how acoramidis affects the total number of heart problems over time in people with ATTR-CM: findings from the ATTRibute-CM study. Future Cardiol. 2026 Aug; 22(8):787-797. PMID: 42544390.

    Read at: PubMed

View All 179 Publications:   View Full Profile in BUMC

Other Positions

  • Professor, Radiology
    Boston University Chobanian & Avedisian School of Medicine
  • Member, Whitaker Cardiovascular Institute
    Boston University
  • Member, Amyloidosis Center
    Boston University
  • Program Director, Clinical and Translational Science Institute
    Boston University Chobanian & Avedisian School of Medicine

Websites

Education

  • University of Pennsylvania School of Medicine, MD
  • Haverford College, BA

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