Frederick L. Ruberg, MD - Chief, Cardiovascular Medicine

Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Frederick L. Ruberg, MD is the Thomas J. Ryan Professor of Cardiovascular Medicine and Professor of Radiology at Boston University (BU) Chobanian & Avedisian School of Medicine and Chief, Section of Cardiovascular Medicine at Boston Medical Center (BMC). Dr. Ruberg attended the University of Pennsylvania Perelman School of Medicine, completed internal medicine training at Brigham and Women’s Hospital, cardiovascular disease fellowship at Boston Medical Center/Boston University School of Medicine, followed by a fellowship in cardiovascular magnetic resonance (CMR) imaging at Beth Israel Deaconess Medical Center in Boston. Committed to research mentorship, he co-directs Workforce Development for the Boston University Clinical and Translational Science Institute (CTSI) and serves as Senior Associate Editor of Circulation: Cardiovascular Imaging. Dr. Ruberg is a Fellow of the American Heart Association and a member of the Association of University Cardiologists. His clinical and research expertise primarily involves cardiac imaging and infiltrative heart disease focused on improving the recognition and care of patients with cardiac amyloidosis, particularly that owing to ATTR and the hereditary genetic TTR variant Val122Ile (or V142I). He is an investigator on numerous NIH-funded awards including co-PI of the $7.2m NHLBI-funded Screening for Cardiac Amyloidosis with Nuclear Imaging (SCAN-MP, R01 HL139671) study. An active clinical cardiologist at the BU Amyloidosis Center, he has also contributed and co-directed numerous collaborative clinical guidelines initiatives, including mostly recently the 2023 the ACC Expert Consensus Decision Pathway document on The Comprehensive Multidisciplinary Care of Patient with Cardiac Amyloidosis. Dr. Ruberg has been recognized with mentorship (2017) and citizenship (2022) awards from the BU Department of Medicine.

Publications

  • Published 5/1/2025

    Griffin JM, Grodin JL, Ruberg FL, Masri A, Hanna M, Maurer MS. Current Landscape of Therapies for Transthyretin Amyloid Cardiomyopathy. JACC Heart Fail. 2025 May; 13(5):685-694. PMID: 40335224.

    Read at: PubMed

  • Published 3/25/2025

    Edwards CV, Ferri GM, Villegas-Galaviz J, Ghosh S, Singh Bawa P, Wang F, Klimtchuk E, Ajayi TB, Morgan GJ, Prokaeva T, Staron A, Ruberg FL, Sanchorawala V, Giadone RM, Murphy GJ. Abnormal global longitudinal strain and reduced serum inflammatory markers in cardiac AL amyloidosis patients without significant amyloid fibril deposition. Amyloid. 2025 Jun; 32(2):179-192. PMID: 40134188.

    Read at: PubMed

  • Published 2/21/2025

    Dorbala S, Adigun R, Alexander KM, Brambatti M, Cuddy SAM, Dispenzieri A, Dunnmon P, Emdin M, Abou Ezzeddine OF, Falk RH, Fontana M, Grodin JL, Guthrie S, Jerosch-Herold M, Hofling AA, Hsu K, Lin G, Masri A, Maurer MS, Mittmann C, Prasad K, Quarta CC, Race JM, Rajendran JG, Ruberg FL, Sachdev V, Sanchorawala V, Signorovitch J, Sirac C, Soman P, Sorensen J, Sperry BW, Stephens AW, Stockbridge NL, Vest J, Wall JS, Wechalekar A, Welsh C, Lousada I. Development of Imaging Endpoints for Clinical Trials in AL and ATTR Amyloidosis: Proceedings of the Amyloidosis Forum. JACC Cardiovasc Imaging. 2025 May; 18(5):602-617. PMID: 39985507.

    Read at: PubMed

  • Published 1/22/2025

    Cheng RK, Leedy D, Ruberg FL. Can Outpatient Worsening Heart Failure Serve as an Endpoint in Clinical Trials of Transthyretin Amyloidosis? J Am Coll Cardiol. 2025 Feb 25; 85(7):762-765. PMID: 39846939.

    Read at: PubMed

  • Published 1/15/2025

    Madhani A, Kotturu N, Fine D, Alreshq R, Saade A, Tannoury T, Tannoury C, Ruberg FL. Spinal amyloid deposits are common among older patients undergoing spinal stenosis decompression surgery. J Gen Fam Med. 2025 May; 26(3):222-230. PMID: 40291058.

    Read at: PubMed

View All 152 Publications:   View Full Profile in BUMC

Other Positions

  • Professor, Radiology
    Boston University Chobanian & Avedisian School of Medicine
  • Member, Whitaker Cardiovascular Institute
    Boston University
  • Member, Amyloidosis Center
    Boston University
  • Program Director, Clinical and Translational Science Institute
    Boston University Chobanian & Avedisian School of Medicine

Websites

Education

  • University of Pennsylvania School of Medicine, MD
  • Haverford College, BA

View all profiles