Douglas L. Rosene, PhD
Professor, Anatomy & Neurobiology
Biography
My research interests are the neurobiological basis of learning, memory, and cognitive dysfunction in normal aging as well recovery of function after neurological insults to the brain such as stroke. These studies use multidisciplinary methods including assessment of behavioral and cognitive function, neural imaging of the brain with MRI, and analysis of neuronal function and organization with neurophysiological, neurohistochemical, neuropharmacological and neuroanatomical methods. The majority of studies utilize non-human primate models of aging, stroke, brain injury and cerebrovascular disease as well as a rat model of prenatal malnutrition.
Other Positions
- Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
Education
- University of Rochester, PhD
- Stanford University, AB
Publications
- Published on 11/28/2024
Stayer-Wilburn O, Brown DI, Woltjer RL, Srinivasan S, Park BS, Shultz P, Vitantonio A, Dimovasili C, Vaughan KL, Starost MF, Rosene D, Mattison JA, Urbanski HF, Kohama SG. Dysregulation of astrocytic Aquaporin-1 in the brains of oldest-old rhesus macaques: the NIA caloric restriction study. Geroscience. 2024 Nov 28. PMID: 39604627.
Read at: PubMed - Published on 9/27/2024
DeVries SA, Dimovasili C, Medalla M, Moore TL, Rosene DL. Dysregulated C1q and CD47 in the aging monkey brain: association with myelin damage, microglia reactivity, and cognitive decline. Front Immunol. 2024; 15:1426975. PMID: 39399501.
Read at: PubMed - Published on 9/23/2024
Dimovasili C, Vitantonio AT, Conner B, Vaughan KL, Mattison JA, Rosene DL. White matter lipid alterations during aging in the rhesus monkey brain. Geroscience. 2024 Sep 23. PMID: 39312153.
Read at: PubMed - Published on 8/1/2024
Amaral AC, Lister JP, Rueckemann JW, Wojnarowicz MW, McGaughy JA, Mokler DJ, Galler JR, Rosene DL, Rushmore RJ. Prenatal protein malnutrition decreases neuron numbers in the parahippocampal region but not prefrontal cortex in adult rats. Nutr Neurosci. 2024 Aug 01; 1-14. PMID: 39088448.
Read at: PubMed - Published on 6/12/2024
Tsolias A, Zhou Y, Mojica CA, Sakharkar M, Tsolias MZ, Moore TL, Rosene DL, Medalla M. Neuroanatomical Substrates of Circuit-Specific Cholinergic Modulation across the Primate Anterior Cingulate Cortex. J Neurosci. 2024 Jun 12; 44(24). PMID: 38719447.
Read at: PubMed - Published on 5/16/2024
Vitantonio AT, Dimovasili C, Mortazavi F, Vaughan KL, Mattison JA, Rosene DL. Long-term calorie restriction reduces oxidative DNA damage to oligodendroglia and promotes homeostatic microglia in the aging monkey brain. Neurobiol Aging. 2024 Sep; 141:1-13. PMID: 38788462.
Read at: PubMed - Published on 3/21/2024
Cheng S, Chang S, Li Y, Novoseltseva A, Lin S, Wu Y, Zhu J, McKee AC, Rosene DL, Wang H, Bigio IJ, Boas DA, Tian L. Enhanced Multiscale Human Brain Imaging by Semi-supervised Digital Staining and Serial Sectioning Optical Coherence Tomography. Res Sq. 2024 Mar 21. PMID: 38562721.
Read at: PubMed - Published on 3/9/2024
Liu YS, Baxi M, Madan CR, Zhan K, Makris N, Rosene DL, Killiany RJ, Cetin-Karayumak S, Pasternak O, Kubicki M, Cao B. Brain age of rhesus macaques over the lifespan. Neurobiol Aging. 2024 Jul; 139:73-81. PMID: 38643691.
Read at: PubMed - Published on 1/8/2024
Amaral DG, Augustinack J, Barbas H, Frosch M, Gabrieli J, Luebke J, Rakic P, Rosene D, Rushmore RJ. The analysis of H.M.'s brain: A brief review of status and plans for future studies and tissue archive. Hippocampus. 2024 Feb; 34(2):52-57. PMID: 38189522.
Read at: PubMed - Published on 12/7/2023
Vogt BA, Rosene DL. Comparison of monkey and human retrosplenial neurocytology. J Comp Neurol. 2023 Dec; 531(18):2044-2061. PMID: 38062543.
Read at: PubMed
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