Douglas L. Rosene, PhD
Professor, Anatomy & Neurobiology
Biography
My research interests are the neurobiological basis of learning, memory, and cognitive dysfunction in normal aging as well recovery of function after neurological insults to the brain such as stroke. These studies use multidisciplinary methods including assessment of behavioral and cognitive function, neural imaging of the brain with MRI, and analysis of neuronal function and organization with neurophysiological, neurohistochemical, neuropharmacological and neuroanatomical methods. The majority of studies utilize non-human primate models of aging, stroke, brain injury and cerebrovascular disease as well as a rat model of prenatal malnutrition.
Other Positions
- Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
Education
- University of Rochester, PhD
- Stanford University, AB
Classes Taught
- GMS AN 702:
- GMS AN 810
- GMS BN 777
- GMS MS 703
- GMSAN702
- GMSAN810
- GMSNE700
- GRSBI755
Publications
- Published on 9/2/2023
Zhou Y, Bhatt H, Mojica CA, Xin H, Pessina MA, Rosene DL, Moore TL, Medalla M. Mesenchymal-derived extracellular vesicles enhance microglia-mediated synapse remodeling after cortical injury in aging Rhesus monkeys. J Neuroinflammation. 2023 Sep 02; 20(1):201. PMID: 37660145.
Read at: PubMed - Published on 5/15/2023
Zhou Y, Bhatt H, Mojica CA, Xin H, Pessina M, Rosene DL, Moore TL, Medalla M. Mesenchymal-Derived Extracellular Vesicles Enhance Microglia-mediated Synapse Remodeling after Cortical Injury in Rhesus Monkeys. Res Sq. 2023 May 15. PMID: 37292805.
Read at: PubMed - Published on 4/28/2023
Moore TL, Medalla M, Ibañez S, Wimmer K, Mojica CA, Killiany RJ, Moss MB, Luebke JI, Rosene DL. Neuronal properties of pyramidal cells in lateral prefrontal cortex of the aging rhesus monkey brain are associated with performance deficits on spatial working memory but not executive function. Geroscience. 2023 Jun; 45(3):1317-1342. PMID: 37106282.
Read at: PubMed - Published on 4/6/2023
Welke LA, Moore TL, Rosene DL, Killiany RJ, Moss MB. Prefrontal and medial temporal interactions in memory functions in the rhesus monkey. Behav Neurosci. 2023 Jun; 137(3):211-222. PMID: 37023305.
Read at: PubMed - Published on 2/8/2023
Moore TL, Medalla M, Iba Ez S, Wimmer K, Mojica CA, Killiany RJ, Moss MB, Luebke JI, Rosene DL. Neuronal properties of pyramidal cells in lateral prefrontal cortex of the aging rhesus monkey brain are associated with performance deficits on spatial working memory but not executive function. bioRxiv. 2023 Feb 08. PMID: 36798388.
Read at: PubMed - Published on 10/7/2022
Kumar AA, Yeo N, Whittaker M, Attra P, Barrick TR, Bridges LR, Dickson DW, Esiri MM, Farris CW, Graham D, Lin WL, Meijles DN, Pereira AC, Perry G, Rosene DL, Shtaya AB, Van Agtmael T, Zamboni G, Hainsworth AH. Vascular Collagen Type-IV in Hypertension and Cerebral Small Vessel Disease. Stroke. 2022 Dec; 53(12):3696-3705. PMID: 36205142.
Read at: PubMed - Published on 9/13/2022
Baxi M, Cetin-Karayumak S, Papadimitriou G, Makris N, van der Kouwe A, Jenkins B, Moore TL, Rosene DL, Kubicki M, Rathi Y. Investigating the contribution of cytoarchitecture to diffusion MRI measures in gray matter using histology. Front Neuroimaging. 2022; 1:947526. PMID: 37555179.
Read at: PubMed - Published on 8/18/2022
Calderazzo S, Covert M, Alba D, Bowley BE, Pessina MA, Rosene DL, Buller B, Medalla M, Moore TL. Neural recovery after cortical injury: Effects of MSC derived extracellular vesicles on motor circuit remodeling in rhesus monkeys. IBRO Neurosci Rep. 2022 Dec; 13:243-254. PMID: 36590089.
Read at: PubMed - Published on 8/5/2022
Dimovasili C, Fair AE, Garza IR, Batterman KV, Mortazavi F, Moore TL, Rosene DL. Aging compromises oligodendrocyte precursor cell maturation and efficient remyelination in the monkey brain. Geroscience. 2023 Feb; 45(1):249-264. PMID: 35930094.
Read at: PubMed - Published on 5/14/2022
Medalla M, Chang W, Ibañez S, Guillamon-Vivancos T, Nittmann M, Kapitonava A, Busch SE, Moore TL, Rosene DL, Luebke JI. Layer-specific pyramidal neuron properties underlie diverse anterior cingulate cortical motor and limbic networks. Cereb Cortex. 2022 05 14; 32(10):2170-2196. PMID: 34613380.
Read at: PubMed
View 186 more publications: View full profile at BUMC