Douglas Rosene, Ph.D.


Phone: 617-638-4061
Fax: 617-638-4922
Location: W-701, BUSM

Dr. Rosene received his B.A. in Psychology from Stanford University and his Ph.D. in Psychology and Neurobiology from the University of Rochester in 1975. He completed a three-year postdoc at Harvard Medical School in Neuroanatomy before assuming a faculty position in the Department of Anatomy and Neurobiology at Boston University School of Medicine. He is co-director for the Laboratory of Cognitive Neurobiology with Dr. Mark Moss.

He is recognized as one of the world’s experts on the anatomy of the temporal lobe limbic system and has published extensively in this area. He is also recognized for his work in the neurobiology of cognitive aging and was Program Director for 15 years of a long-standing NIH Program Project studying the neural bases of cognitive decline using the rhesus monkey as a model of normal human aging. Currently he is principal investigator or co-investigator on several other NIH grants that study various aspects of aging and age-related disease in primate models. A more recent research interest is the neurobiological bases and facilitation of recovery of fine motor function after cortical stroke in the rhesus monkey with his colleague Dr. Tara L Moore. Most recently he has been funded by NSF to study the neurobiological validity of diffusion MRI tractography of the human connectome.

Dr, Rosene is Course Manager of Principles of Neuroscience 1 (Systems Neurobiology), the first year course for PhD students concentrating on Neuroscience as well as Course Manager for an advance seminar course in the Neurobiology of Learning and Memory. He also teaches in the Medical Neuroscience course and in department courses in Neuroscience Methods and in the Neurobiology of Aging. In addition, Dr. Rosene has been the recipient of several teaching awards including the Stanley Robbins Award for teaching, the most prestigious award for teaching at the Medical School.


Recent Publications

Chang YM, Rosene DL, Killiany RJ, Mangiamele LA, Luebke JI. 2004 Increased Action Potential Firing Rates of Layer 2/3 Pyramidal Cells in the Prefrontal Cortex are Significantly Related to Cognitive Performance in Aged Monkeys. Cereb Cortex, in press.

Peters A, Rosene DL 2003 In aging, is it gray or white? J Comp Neurol. 462:139-43

O’Brien, S.E. Rosene, D.L., and Luebke, J.J. 2003 GABAa receptor-mediated neurotransmission in the dentate gyrus of the rhesus monkey: A comparison with the rat. Synapse. 49:287-9.

McDannold, N., Moss, M.B., Killiany, R., Rosene, D.L., King, R.L, Jolesz, F.A. and Hynynen, K. 2003 MRI-guided focused ultrasound surgery in the brain: Tests in a primate model. Magn. Reson. Med., 49:1188-1191.

Moore, TL, Killiany, RJ, Herndon, JG, Rosene, DL and Moss, MB. 2003 Impairment in asbtraction and set shifting in aged Rhesus monkeys. Neurobiology of Aging, 24: 125-134.

Blatt, G.J., Pandya, D.N. and Rosene, D.L. 2003 Parcellation of cortical afferents to three distinct sectors in the parahippocampal gyrus of the rhesus monkey: and anatomical and neurophysiological study. J. Comp. Neurol. , 466:161-79.