Douglas Rosene, Ph.D.


Phone: 617-638-4061
Fax: 617-638-4922
Location: W-701, BUSM

Dr. Rosene received his B.A. in Psychology from Stanford University and his Ph.D. in Psychology and Neurobiology from the University of Rochester in 1975. He completed a three-year postdoc at Harvard Medical School in Neuroanatomy before assuming a faculty position in the Department of Anatomy and Neurobiology at Boston University School of Medicine. He is co-director for the Laboratory of Cognitive Neurobiology with Dr. Mark Moss.

He is recognized as one of the world’s experts on the anatomy of the temporal lobe limbic system and has published extensively in this area. He is also recognized for his work in the neurobiology of cognitive aging and was Program Director for 15 years of a long-standing NIH Program Project studying the neural bases of cognitive decline using the rhesus monkey as a model of normal human aging. Currently he is principal investigator or co-investigator on several other NIH grants that study various aspects of aging and age-related disease in primate models. A more recent research interest is the neurobiological bases and facilitation of recovery of fine motor function after cortical stroke in the rhesus monkey with his colleague Dr. Tara L Moore. Most recently he has been funded by NSF to study the neurobiological validity of diffusion MRI tractography of the human connectome.

Dr, Rosene is Course Manager of Principles of Neuroscience 1 (Systems Neurobiology), the first year course for PhD students concentrating on Neuroscience as well as Course Manager for an advance seminar course in the Neurobiology of Learning and Memory. He also teaches in the Medical Neuroscience course and in department courses in Neuroscience Methods and in the Neurobiology of Aging. In addition, Dr. Rosene has been the recipient of several teaching awards including the Stanley Robbins Award for teaching, the most prestigious award for teaching at the Medical School.


Recent Publications

McGaughy JA, Amaral AC, Rushmore RJ, Mokler DJ, Morgane PJ, Rosene DL, Galler JR (2014) Prenatal Malnutrition Leads to Deficits in Attentional Set Shifting and Decreases Metabolic Activity in Prefrontal Subregions that Control Executive Function Developmental Neuroscience 36(6):532-41.

Amaral AC, Jakovcevsk M, J.A. McGaughy JA Calderwood SK, Mokler DJ Rushmore RJ Galler JR Akbarian SA, Rosene, DL (2014) Prenatal Protein Malnutrition Decreases KCNJ3 and 2DG Activity  in Rat Prefrontal Cortex   Neuroscience 12; 286:79-86.

Aggleton, J_, Rosene DL, Saunders RC (2015) Complementary patterns of direct amygdala and hippocampal projections to the macaque prefrontal cortex. Cerebral Cortex In Press, January 2015.

Fischer LK, McGaughy JA, Bradshaw SE, Weissner WJ, Amaral AC, Rosene DL, Mokler DJ, Fitzmaurice GM, Galler JR, (2015) Prenatal protein level impacts homing behavior in Long-Evans rat pups Nutritional Neuroscience 01/2015; DOI:10.1179/1476830515Y.0000000001.

Seth N, Masood F, Sledge JB, Graham WA, Rosene DL, Westmoreland S, Macri S, Sejdic E, Hoggatt A, Simmons H, Abdullah HA, Nesathurai S, (2015) Humane Non-Human Primate Model of Traumatic Spinal Cord Injury: Quan- titative Analysis of Electromyographic Data. Open Journal of Veterinary Medicine, 5, 161-168.

Ngwenya LB, Heyworth NC, Shwe Y, Moore TL, and Rosene DL (2015) Age-related changes in dentate gyrus cell numbers, neurogenesis, and associations with cognitive impairments in the rhesus monkey. Frontiers Systems Neuroscience July 2015.

Mortazavi F and Rosene, DL (2015) Neuroanatomical techniques for analysis of axonal trajectories in the cerebral cortex of the rhesus monkey. Chapter 17 In: Axons and Brain Architecture (Ed.  KS Rockland) Elsevier Publishing, In Press 2015.