Douglas L. Rosene, PhD

Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

My research interests are the neurobiological basis of learning, memory, and cognitive dysfunction in normal aging as well recovery of function after neurological insults to the brain such as stroke. These studies use multidisciplinary methods including assessment of behavioral and cognitive function, neural imaging of the brain with MRI, and analysis of neuronal function and organization with neurophysiological, neurohistochemical, neuropharmacological and neuroanatomical methods. The majority of studies utilize non-human primate models of aging, stroke, brain injury and cerebrovascular disease as well as a rat model of prenatal malnutrition.

Publications

  • Published 3/24/2025

    Dimovasili C, Vitantonio AT, Conner B, Vaughan KL, Mattison JA, Rosene DL. Correction to: White matter lipid alterations during aging in the rhesus monkey brain. Geroscience. 2025 Mar 24. PMID: 40126813.

    Read at: PubMed

  • Published 1/20/2025

    Cheng S, Chang S, Li Y, Novoseltseva A, Lin S, Wu Y, Zhu J, McKee AC, Rosene DL, Wang H, Bigio IJ, Boas DA, Tian L. Enhanced multiscale human brain imaging by semi-supervised digital staining and serial sectioning optical coherence tomography. Light Sci Appl. 2025 Jan 20; 14(1):57. PMID: 39833166.

    Read at: PubMed

  • Published 11/28/2024

    Stayer-Wilburn O, Brown DI, Woltjer RL, Srinivasan S, Park BS, Shultz P, Vitantonio A, Dimovasili C, Vaughan KL, Starost MF, Rosene D, Mattison JA, Urbanski HF, Kohama SG. Dysregulation of astrocytic Aquaporin-1 in the brains of oldest-old rhesus macaques: the NIA caloric restriction study. Geroscience. 2025 Feb; 47(1):781-793. PMID: 39604627.

    Read at: PubMed

  • Published 9/27/2024

    DeVries SA, Dimovasili C, Medalla M, Moore TL, Rosene DL. Dysregulated C1q and CD47 in the aging monkey brain: association with myelin damage, microglia reactivity, and cognitive decline. Front Immunol. 2024; 15:1426975. PMID: 39399501.

    Read at: PubMed

  • Published 9/23/2024

    Dimovasili C, Vitantonio AT, Conner B, Vaughan KL, Mattison JA, Rosene DL. White matter lipid alterations during aging in the rhesus monkey brain. Geroscience. 2024 Sep 23. PMID: 39312153.

    Read at: PubMed

View All 211 Publications:   View Full Profile in BUMC

Other Positions

  • Graduate Faculty (Primary Mentor of Grad Students)
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Websites

Education

  • University of Rochester, PhD
  • Stanford University, AB

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