Douglas L. Rosene, PhD

Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

My research interests are the neurobiological basis of learning, memory, and cognitive dysfunction in normal aging as well recovery of function after neurological insults to the brain such as stroke. These studies use multidisciplinary methods including assessment of behavioral and cognitive function, neural imaging of the brain with MRI, and analysis of neuronal function and organization with neurophysiological, neurohistochemical, neuropharmacological and neuroanatomical methods. The majority of studies utilize non-human primate models of aging, stroke, brain injury and cerebrovascular disease as well as a rat model of prenatal malnutrition.

Publications

  • Published 9/17/2025

    Schmahmann JD, Killiany RD, Vangel M, Moore TL, Moss MB, Rosene DL. Cerebellar dentate nucleus lesions in monkey reveal both a motor-cognitive dichotomy and within-cognition dichotomy of dorsal vs ventral stream processing. Sci Rep. 2025 Sep 17; 15(1):32563. PMID: 40962811.

    Read at: PubMed

  • Published 8/11/2025

    Qiang Y, Gu W, Jang D, Shin Y, Shi D, Seo KJ, Li G, Vinnikova S, Wu S, Iyer A, Artoni P, Ryu J, Bai T, Dhawan V, Medalla M, Rosene DL, Moore TL, Koppes AN, Koppes R, Liou JY, Chandrasekaran C, Cui XT, Wang S, Fang H. Monolithic three-dimensional neural probes from deterministic rolling of soft electronics. Nat Electron. 2025 Aug; 8(8):721-737. PMID: 40951322.

    Read at: PubMed

  • Published 8/1/2025

    Dimovasili C, Vitantonio AT, Conner B, Vaughan KL, Mattison JA, Rosene DL. Correction to: White matter lipid alterations during aging in the rhesus monkey brain. Geroscience. 2025 Aug; 47(4):6103-6106. PMID: 40126813.

    Read at: PubMed

  • Published 7/9/2025

    McCann RP, Bowley B, Pessina M, Yang Q, Xin H, DeVries SA, Wang M, Zhang Y, Chopp M, Zhang Z, Rosene DL, Zeldich E, Medalla M, Moore TL. Reduction of inflammatory biomarkers underlies extracellular vesicle mediated functional recovery in an aged monkey model of cortical injury. Front Aging Neurosci. 2025; 17:1605144. PMID: 40703679.

    Read at: PubMed

  • Published 1/20/2025

    Cheng S, Chang S, Li Y, Novoseltseva A, Lin S, Wu Y, Zhu J, McKee AC, Rosene DL, Wang H, Bigio IJ, Boas DA, Tian L. Enhanced multiscale human brain imaging by semi-supervised digital staining and serial sectioning optical coherence tomography. Light Sci Appl. 2025 Jan 20; 14(1):57. PMID: 39833166.

    Read at: PubMed

View All 215 Publications:   View Full Profile in BUMC

Other Positions

  • Graduate Faculty (Primary Mentor of Grad Students)
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Websites

Education

  • University of Rochester, PhD
  • Stanford University, AB

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