Darrell N. Kotton, MD

Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Darrell N. Kotton, MD is the founding director of the Center for Regenerative Medicine of Boston University and Boston Medical Center. He is a physician-scientist with attending physician duties in pulmonary and critical care medicine at Boston Medical Center and is the David C. Seldin Professor in the department of medicine and in the department of pathology and laboratory medicine at the Boston University Chobanian and Avedesian School of Medicine. Dr. Kotton is an Allen Distinguished Investigator, a Paul G. Allen Frontiers Group advised program of the Paul G. Allen Family Foundation. He is also an elected member of the American Society of Clinical Investigators and the Association of American Physicians. He leads a basic research laboratory, funded continuously by the NIH since 2004, focused on lung regeneration and stem cell biology, and he serves on the NIH’s National Heart Lung and Blood Institute’s Board of External Experts. He is the recipient of the American Thoracic Society’s “Recognition Award for Scientific Accomplishments” (2018), the AAMC inaugural national “Research Resources Sharing Award” (2017), the Alpha-1 Foundation’s “Researcher of the Year” (2013) and “Shillelagh” (2010) Awards, Boston University’s Graduate Medical Sciences Educator of the Year Award (2018), and the Robert Dawes Evans Senior Research Mentor Award from Boston University.

Expertise: Stem Cell Biology; iPS cells; Reprogramming; Gene Therapy; Lung Developmental Biology.

Publications

  • Published 3/23/2026

    Hayes KM, Boldt K, Schnorr PJ, Bawa P, Abyazi ML, Ware MS, Gyimesi G, James M, Ko HM, Cunningham-Rundles C, Mizgerd JP, Mostoslavsky G, Kotton DN, Maglione PJ. Heterozygous NFKB1 variant causes inflammatory dysregulation shaped by broader genetic context in common variable immunodeficiency. JCI Insight. 2026 Mar 23; 11(6). PMID: 41869721.

    Read at: PubMed

  • Published 3/9/2026

    Warheit-Niemi HI, Huang J, Cook KCS, Alysandratos KD, Fernandes S, Basak P, Zhao B, Vilker E, Villacorta-Martin C, Elitz A, Bawa P, Toth A, Herriges MJ, Kotton DN, Zacharias WJ. The chromatin remodeling complex PRC2 safeguards cell fate in alveolar epithelial type 2 cells. bioRxiv. 2026 Mar 09. PMID: 41867819.

    Read at: PubMed

  • Published 3/9/2026

    Cooney AL, Lamer S, Yang P, Wegner DJ, White FV, Cole FS, Wohlford-Lenane C, Hennessey E, Bawa P, Kotton DN, Sinn PL, Wambach JA, Mccray PB. Lentiviral-mediated gene complementation to rescue pathogenic ABCA3 variants. Am J Respir Cell Mol Biol. 2026 Mar 09. PMID: 42089300.

    Read at: PubMed

  • Published 2/2/2026

    Sen C, Langerman J, Alysandratos K, Alber AB, Cherry C, Castillo K, Siegel S, Chandran RR, Choi W, Rickabaugh T, Kotton DN, Plath K, Gomperts BN. Modeling cell-cell interactions to advance drug discovery in Idiopathic Pulmonary Fibrosis. bioRxiv. 2026 Feb 02. PMID: 41676623.

    Read at: PubMed

  • Published 2/1/2026

    Kohn A, Herriges MJ, Basak P, Ma L, Thapa BR, Kotton DN, Hawkins FJ. Targeted Preconditioning and Cell Transplantation in the Murine Lower Respiratory Tract. Am J Respir Cell Mol Biol. 2026 Feb 01; 74(2):155-166. PMID: 40540686.

    Read at: PubMed

View All 194 Publications:   View Full Profile in BUMC

Other Positions

  • Director, Center for Regenerative Medicine
    Boston University
  • Professor, Pathology & Laboratory Medicine
    Boston University Chobanian & Avedisian School of Medicine
  • Investigator
    Framingham Heart Study
  • Member, Pulmonary Center
    Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research
    Boston University
  • Member, Genome Science Institute
    Boston University
  • Graduate Medical Sciences Educator and Mentor (Primary Mentor of Graduate Students)
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Websites

Education

  • Washington University School of Medicine, MD
  • University of Pennsylvania, BA

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