Darrell Nelson Kotton, MD
Professor, Medicine
Biography
Darrell N. Kotton, MD is the founding director of the Center for Regenerative Medicine of Boston University and Boston Medical Center. He is a physician-scientist with attending physician duties in pulmonary and critical care medicine at Boston Medical Center and is the David C. Seldin Professor in the department of medicine and in the department of pathology and laboratory medicine at the Boston University Chobanian and Avedesian School of Medicine. Dr. Kotton is an Allen Distinguished Investigator, a Paul G. Allen Frontiers Group advised program of the Paul G. Allen Family Foundation. He is also an elected member of the American Society of Clinical Investigators and the Association of American Physicians. He leads a basic research laboratory, funded continuously by the NIH since 2004, focused on lung regeneration and stem cell biology, and he serves on the NIH’s National Heart Lung and Blood Institute’s Board of External Experts. He is the recipient of the American Thoracic Society’s “Recognition Award for Scientific Accomplishments” (2018), the AAMC inaugural national “Research Resources Sharing Award” (2017), the Alpha-1 Foundation’s “Researcher of the Year” (2013) and “Shillelagh” (2010) Awards, Boston University’s Graduate Medical Sciences Educator of the Year Award (2018), and the Robert Dawes Evans Senior Research Mentor Award from Boston University.
Expertise: Stem Cell Biology; iPS cells; Reprogramming; Gene Therapy; Lung Developmental Biology.
Other Positions
- Director, Center for Regenerative Medicine, Boston University
- Professor, Pathology & Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine
- Investigator, Framingham Heart Study
- Member, Pulmonary Center, Boston University
- Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
- Member, Genome Science Institute, Boston University
- Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
Education
- Washington University School of Medicine, MD
- University of Pennsylvania, BA
Publications
- Published on 6/17/2024
Gagnon KA, Huang J, Hix OT, Hui VW, Hinds A, Bullitt E, Eyckmans J, Kotton DN, Chen CS. Multicompartment duct platform to study epithelial-endothelial crosstalk associated with lung adenocarcinoma. APL Bioeng. 2024 Jun; 8(2):026126. PMID: 38911024.
Read at: PubMed - Published on 4/20/2024
Tang W, Huang J, Pegoraro AF, Zhang JH, Tang Y, Bi D, Kotton DN, Guo M. Nuclear size-regulated emergence of topological packing order on growing human lung alveolospheres. bioRxiv. 2024 Apr 20. PMID: 38659777.
Read at: PubMed - Published on 4/19/2024
Burgess CL, Huang J, Bawa PS, Alysandratos KD, Minakin K, Ayers LJ, Morley MP, Babu A, Villacorta-Martin C, Yampolskaya M, Hinds A, Thapa BR, Wang F, Matschulat A, Mehta P, Morrisey EE, Varelas X, Kotton DN. Generation of human alveolar epithelial type I cells from pluripotent stem cells. Cell Stem Cell. 2024 May 02; 31(5):657-675.e8. PMID: 38642558.
Read at: PubMed - Published on 3/28/2024
Rodriguez LR, Alysandratos KD, Katzen J, Murthy A, Barboza WR, Tomer Y, Acin-Perez R, Petcherski A, Minakin K, Carson P, Iyer S, Chavez K, Cooper CH, Babu A, Weiner AI, Vaughan AE, Arany Z, Shirihai OS, Kotton DN, Beers MF. Impaired AMPK Control of Alveolar Epithelial Cell Metabolism Promotes Pulmonary Fibrosis. bioRxiv. 2024 Mar 28. PMID: 38585863.
Read at: PubMed - Published on 3/19/2024
Eiken MK, Childs CJ, Brastrom LK, Frum T, Plaster EM, Shachaf O, Pfeiffer S, Levine JE, Alysandratos KD, Kotton DN, Spence JR, Loebel C. Nascent matrix deposition supports alveolar organoid formation from aggregates in synthetic hydrogels. bioRxiv. 2024 Mar 19. PMID: 38562781.
Read at: PubMed - Published on 3/15/2024
Basil MC, Alysandratos KD, Kotton DN, Morrisey EE. Lung repair and regeneration: Advanced models and insights into human disease. Cell Stem Cell. 2024 Apr 04; 31(4):439-454. PMID: 38492572.
Read at: PubMed - Published on 2/15/2024
Montesi SB, Gomez CR, Beers M, Brown R, Chattopadhyay I, Flaherty KR, Garcia CK, Gomperts B, Hariri LP, Hogaboam CM, Jenkins RG, Kaminski N, Kim GHJ, Königshoff M, Kolb M, Kotton DN, Kropski JA, Lasky J, Magin CM, Maher TM, McCormick M, Moore BB, Nickerson-Nutter C, Oldham J, Podolanczuk AJ, Raghu G, Rosas I, Rowe SM, Schmidt WT, Schwartz D, Shore JE, Spino C, Craig JM, Martinez FJ. Pulmonary Fibrosis Stakeholder Summit: A Joint NHLBI, Three Lakes Foundation, and Pulmonary Fibrosis Foundation Workshop Report. Am J Respir Crit Care Med. 2024 Feb 15; 209(4):362-373. PMID: 38113442.
Read at: PubMed - Published on 2/7/2024
Miao Y, Tan C, Pek NM, Yu Z, Iwasawa K, Kechele DO, Sundaram N, Pastrana-Gomez V, Kishimoto K, Yang MC, Jiang C, Tchieu J, Whitsett JA, McCracken KW, Rottier RJ, Kotton DN, Helmrath MA, Wells JM, Takebe T, Zorn AM, Chen YW, Guo M, Gu M. Deciphering Endothelial and Mesenchymal Organ Specification in Vascularized Lung and Intestinal Organoids. bioRxiv. 2024 Feb 07. PMID: 38370768.
Read at: PubMed - Published on 1/16/2024
Sun YL, Hennessey EE, Heins H, Yang P, Villacorta-Martin C, Kwan J, Gopalan K, James M, Emili A, Cole FS, Wambach JA, Kotton DN. Human pluripotent stem cell modeling of alveolar type 2 cell dysfunction caused by ABCA3 mutations. J Clin Invest. 2024 Jan 16; 134(2). PMID: 38226623.
Read at: PubMed - Published on 1/9/2024
Hume AJ, Olejnik J, White MR, Huang J, Turcinovic J, Heiden B, Bawa PS, Williams CJ, Gorham NG, Alekseyev YO, Connor JH, Kotton DN, Mühlberger E. Heat Inactivation of Nipah Virus for Downstream Single-Cell RNA Sequencing Does Not Interfere with Sample Quality. Pathogens. 2024 Jan 09; 13(1). PMID: 38251369.
Read at: PubMed
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