Darrell N. Kotton, MD

Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Darrell N. Kotton, MD is the founding director of the Center for Regenerative Medicine of Boston University and Boston Medical Center. He is a physician-scientist with attending physician duties in pulmonary and critical care medicine at Boston Medical Center and is the David C. Seldin Professor in the department of medicine and in the department of pathology and laboratory medicine at the Boston University Chobanian and Avedesian School of Medicine. Dr. Kotton is an Allen Distinguished Investigator, a Paul G. Allen Frontiers Group advised program of the Paul G. Allen Family Foundation. He is also an elected member of the American Society of Clinical Investigators and the Association of American Physicians. He leads a basic research laboratory, funded continuously by the NIH since 2004, focused on lung regeneration and stem cell biology, and he serves on the NIH’s National Heart Lung and Blood Institute’s Board of External Experts. He is the recipient of the American Thoracic Society’s “Recognition Award for Scientific Accomplishments” (2018), the AAMC inaugural national “Research Resources Sharing Award” (2017), the Alpha-1 Foundation’s “Researcher of the Year” (2013) and “Shillelagh” (2010) Awards, Boston University’s Graduate Medical Sciences Educator of the Year Award (2018), and the Robert Dawes Evans Senior Research Mentor Award from Boston University.

Expertise: Stem Cell Biology; iPS cells; Reprogramming; Gene Therapy; Lung Developmental Biology.

Publications

  • Published 10/14/2025

    Dobie AC, Win W, Kotton DN, Monaghan JR. Toward Human Lung Regeneration: Gaining Insights from the Axolotl Salamander Ambystoma mexicanum. Am J Respir Cell Mol Biol. 2025 Oct 14. PMID: 41086376.

    Read at: PubMed

  • Published 10/6/2025

    Yabaji SM, Lata S, Tseng AE, Araveti PB, Lo M, Gavrish I, O'Connell AK, Gertje HP, Belkina AC, Thurman CE, Kiyokawa H, Kotton D, Tan S, Endsley JJ, Bishai WR, Crossland N, Kobzik L, Kramnik I. Dysplastic lung repair fosters a tuberculosis-promoting microenvironment through maladaptive macrophage polarization. PLoS Pathog. 2025 Oct; 21(10):e1013563. PMID: 41052208.

    Read at: PubMed

  • Published 9/30/2025

    Hoffman ET, Shah A, Barboza WR, Rodriguez LR, Dherwani R, Dooley PE, Minakin K, Tomer Y, Ayers LJ, Jones D, Murthy A, Bennett A, Lange AN, Bawa PS, Wang F, Babu A, Chavez K, Nakamoto RS, Cooper CH, Basil MC, Raredon MSB, Kotton DN, Alysandratos KD, Katzen J. Aberrant intermediate alveolar epithelial cells promote pathogenic activation of lung fibroblasts in preclinical fibrosis models. Nat Commun. 2025 Sep 30; 16(1):8710. PMID: 41027873.

    Read at: PubMed

  • Published 8/30/2025

    Cooney AL, Lamer S, Yang P, Wegner DJ, White FV, Cole FS, Wohlford-Lenane C, Hennessey E, Bawa P, Kotton DN, Sinn PL, Wambach JA, McCray PB. Lentiviral-mediated gene complementation rescues pathogenic ABCA3 variants. bioRxiv. 2025 Aug 30. PMID: 40909633.

    Read at: PubMed

  • Published 8/1/2025

    Lingappan K, Sundar IK, Prakash YS, Redente EF, Sin DD, Han MK, Lahm T, Krymskaya VP, Kotton DN, Kulkarni HS, Jain R, Königshoff M, Eghbali M, Anguera M, Arnold A, Silveyra P, DeMeo DL. Addressing Sex as a Biological Variable in Preclinical Models of Lung Disease: An Official American Thoracic Society Research Statement. Am J Respir Crit Care Med. 2025 Aug; 211(8):1346-1368. PMID: 40748009.

    Read at: PubMed

View All 187 Publications:   View Full Profile in BUMC

Other Positions

  • Director, Center for Regenerative Medicine
    Boston University
  • Professor, Pathology & Laboratory Medicine
    Boston University Chobanian & Avedisian School of Medicine
  • Investigator
    Framingham Heart Study
  • Member, Pulmonary Center
    Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research
    Boston University
  • Member, Genome Science Institute
    Boston University
  • Graduate Faculty (Primary Mentor of Grad Students)
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Websites

Education

  • Washington University School of Medicine, MD
  • University of Pennsylvania, BA

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