Christopher V. Gabel, PhD
Associate Professor, Pharmacology, Physiology & Biophysics
Biography
Our research program is focused on the development and application of femtosecond laser surgery and optical neurophysiology to the study of the nervous system of the nematode worm C. elegans. Using tightly focused pulses from an ultrafast laser, we can ablate regions of biological tissue with submicron precision, making it possible to snip individual nerve fibers within an intact worm (Fig 1). This enables in vivo study of neural regeneration and dissection of neurocircuitry at a new level of resolution. A small transparent body, simple stereotyped nervous system and powerful genetic tools combined to make C. elegans an ideal model organism for this work. Femtosecond laser technology applied to this versatile and tractable system allows us to tackle fundamental questions in neural regeneration and function.
Other Positions
- Associate Professor, Pharmacology, Physiology & Biophysics, Boston University Chobanian & Avedisian School of Medicine
- Member, Genome Science Institute, Boston University
- Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
Websites
Education
- Harvard University, PhD
- Princeton University, BA
Publications
- Published on 6/26/2024
Guo R, Yang Q, Chang AS, Hu G, Greene J, Gabel CV, You S, Tian L. EventLFM: event camera integrated Fourier light field microscopy for ultrafast 3D imaging. Light Sci Appl. 2024 Jun 26; 13(1):144. PMID: 38918363.
Read at: PubMed - Published on 2/9/2024
Yadav DK, Chang AC, Grooms NWF, Chung SH, Gabel CV. O-GlcNAc signaling increases neuron regeneration through one-carbon metabolism in Caenorhabditis elegans. Elife. 2024 Feb 09; 13. PMID: 38334260.
Read at: PubMed - Published on 7/1/2023
Chang AS, Wirak GS, Li D, Gabel CV, Connor CW. Measures of Information Content during Anesthesia and Emergence in the Caenorhabditis elegans Nervous System. Anesthesiology. 2023 Jul 01; 139(1):49-62. PMID: 37027802.
Read at: PubMed - Published on 6/15/2022
Wirak GS, Florman J, Alkema MJ, Connor CW, Gabel CV. Age-associated changes to neuronal dynamics involve a disruption of excitatory/inhibitory balance in C. elegans. Elife. 2022 Jun 15; 11. PMID: 35703498.
Read at: PubMed - Published on 3/1/2021
Shao W, Kilic K, Yin W, Wirak G, Qin X, Feng H, Boas D, Gabel CV, Yi J. Wide field-of-view volumetric imaging by a mesoscopic scanning oblique plane microscopy with switchable objective lenses. Quant Imaging Med Surg. 2021 Mar; 11(3):983-997. PMID: 33654671.
Read at: PubMed - Published on 9/1/2020
Wirak GS, Gabel CV, Connor CW. Isoflurane Exposure in Juvenile Caenorhabditis elegans Causes Persistent Changes in Neuron Dynamics. Anesthesiology. 2020 09; 133(3):569-582. PMID: 32452864.
Read at: PubMed - Published on 7/1/2020
Awal MR, Wirak GS, Gabel CV, Connor CW. Collapse of Global Neuronal States in Caenorhabditis elegans under Isoflurane Anesthesia. Anesthesiology. 2020 07; 133(1):133-144. PMID: 32282426.
Read at: PubMed - Published on 4/1/2020
Song W, Matlock A, Fu S, Qin X, Feng H, Gabel CV, Tian L, Yi J. LED array reflectance microscopy for scattering-based multi-contrast imaging. Opt Lett. 2020 Apr 01; 45(7):1647-1650. PMID: 32235964.
Read at: PubMed - Published on 3/11/2020
Harreguy MB, Marfil V, Grooms NWF, Gabel CV, Chung SH, Haspel G. Ytterbium-doped fibre femtosecond laser offers robust operation with deep and precise microsurgery of C. elegans neurons. Sci Rep. 2020 03 11; 10(1):4545. PMID: 32161333.
Read at: PubMed - Published on 11/28/2019
Cai H, Wang YL, Wainner RT, Iftimia NV, Gabel CV, Chung SH. Wedge prism approach for simultaneous multichannel microscopy. Sci Rep. 2019 11 28; 9(1):17795. PMID: 31780755.
Read at: PubMed
View 34 more publications: View full profile at BUMC