Christopher V. Gabel, PhD

Associate Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Our research program is focused on the development and application of femtosecond laser surgery and optical neurophysiology to the study of the nervous system of the nematode worm C. elegans. Using tightly focused pulses from an ultrafast laser, we can ablate regions of biological tissue with submicron precision, making it possible to snip individual nerve fibers within an intact worm (Fig 1). This enables in vivo study of neural regeneration and dissection of neurocircuitry at a new level of resolution. A small transparent body, simple stereotyped nervous system and powerful genetic tools combined to make C. elegans an ideal model organism for this work. Femtosecond laser technology applied to this versatile and tractable system allows us to tackle fundamental questions in neural regeneration and function.

Publications

  • Published 6/26/2024

    Guo R, Yang Q, Chang AS, Hu G, Greene J, Gabel CV, You S, Tian L. EventLFM: event camera integrated Fourier light field microscopy for ultrafast 3D imaging. Light Sci Appl. 2024 Jun 26; 13(1):144. PMID: 38918363.

    Read at: PubMed

  • Published 2/9/2024

    Yadav DK, Chang AC, Grooms NWF, Chung SH, Gabel CV. O-GlcNAc signaling increases neuron regeneration through one-carbon metabolism in Caenorhabditis elegans. Elife. 2024 Feb 09; 13. PMID: 38334260.

    Read at: PubMed

  • Published 7/1/2023

    Chang AS, Wirak GS, Li D, Gabel CV, Connor CW. Measures of Information Content during Anesthesia and Emergence in the Caenorhabditis elegans Nervous System. Anesthesiology. 2023 Jul 01; 139(1):49-62. PMID: 37027802.

    Read at: PubMed

  • Published 6/15/2022

    Wirak GS, Florman J, Alkema MJ, Connor CW, Gabel CV. Age-associated changes to neuronal dynamics involve a disruption of excitatory/inhibitory balance in C. elegans. Elife. 2022 Jun 15; 11. PMID: 35703498.

    Read at: PubMed

  • Published 3/1/2021

    Shao W, Kilic K, Yin W, Wirak G, Qin X, Feng H, Boas D, Gabel CV, Yi J. Wide field-of-view volumetric imaging by a mesoscopic scanning oblique plane microscopy with switchable objective lenses. Quant Imaging Med Surg. 2021 Mar; 11(3):983-997. PMID: 33654671.

    Read at: PubMed

View All 44 Publications:   View Full Profile in BUMC

Other Positions

  • Associate Professor, Pharmacology, Physiology & Biophysics
    Boston University Chobanian & Avedisian School of Medicine
  • Member, Genome Science Institute
    Boston University
  • Graduate Faculty (Primary Mentor of Grad Students)
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Websites

Education

  • Harvard University, PhD
  • Princeton University, BA

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