Catherine E. Costello, PhD
William Fairfield Warren Distinguished Professor, Biochemistry & Cell Biology
Biography
Catherine Costello came to Boston University in 1994. That year she established the Center for Biomedical Mass Spectrometry, which has become an internationally recognized research center. She holds her primary appointment in the Chobanian & Avedisian School of Medicine Biochemistry & Cell Biology Department, with secondary appointments in the Department of Physiology & Biophysics and the Department of Chemistry. Her research, which focuses on determining the structures and functions of biologically important polymers, has revolutionized an important area of biochemistry by providing insights into the structures of molecules responsible for human disease. She is the author or co-author of more than 400 scientific papers, serves on a number of advisory boards and editorial boards of major journals, and has received numerous awards and honors, including the 2009 Thomson Medal from the International Mass Spectrometry Foundation (IMSF), the 2010 Field and Franklin Award from the American Chemical Society (ACS), and the 2017 Distinguished Contribution Award from the American Society for Mass Spectrometry (ASMS), the three highest honors in her field. She is a Fellow of the ACS and the American Association for the Advancement of Science. She has served as President of IMSF, ASMS, and the Human Proteome Organization.
Other Positions
- Professor, Chemistry, Boston University Chobanian & Avedisian School of Medicine
- Research Professor, Pharmacology, Physiology & Biophysics, Boston University Chobanian & Avedisian School of Medicine
- Director, Center for Biomedical Mass Spectrometry, Boston University Chobanian & Avedisian School of Medicine
- Member, BU-BMC Cancer Center, Boston University
- Member, Amyloidosis Center, Boston University
- Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
- Member, Genome Science Institute, Boston University
- Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
Education
- Georgetown University, PhD
- Georgetown University, MS
- Emmanuel College, AB
Publications
- Published on 2/5/2025
Dohadwala S, Shah P, Farrell M, Politch J, Marathe J, Costello CE, Anderson DJ. Sialidases derived from Gardnerella vaginalis remodel the sperm glycocalyx and impair sperm function. bioRxiv. 2025 Feb 05. PMID: 39975358.
Read at: PubMed - Published on 7/25/2024
Reed ER, Chandler KB, Lopez P, Costello CE, Andersen SL, Perls TT, Li M, Bae H, Soerensen M, Monti S, Sebastiani P. Cross-platform proteomics signatures of extreme old age. Geroscience. 2025 Feb; 47(1):1199-1220. PMID: 39048883.
Read at: PubMed - Published on 7/11/2024
Xia C, Mernie E, Zaia J, Costello CE, Lin C. Accurate Collisional Cross Section Measurement by Multipass Cyclic Ion Mobility Spectrometry. Anal Chem. 2024 Jul 23; 96(29):11959-11968. PMID: 38990519.
Read at: PubMed - Published on 4/14/2024
Reed ER, Chandler KB, Lopez P, Costello CE, Andersen SL, Perls TT, Li M, Bae H, Soerensen M, Monti S, Sebastiani P. Cross-platform proteomics signatures of extreme old age. bioRxiv. 2024 Apr 14. PMID: 38645061.
Read at: PubMed - Published on 3/6/2024
Nador E, Xia C, Santangelo PJ, Whaley KJ, Costello CE, Anderson DJ. Platform-Specific Fc N-Glycan Profiles of an Antisperm Antibody. Antibodies (Basel). 2024 Mar 06; 13(1). PMID: 38534207.
Read at: PubMed - Published on 1/11/2024
Li R, Xia C, Wu S, Downs MJ, Tong H, Tursumamat N, Zaia J, Costello CE, Lin C, Wei J. Direct and Detailed Site-Specific Glycopeptide Characterization by Higher-Energy Electron-Activated Dissociation Tandem Mass Spectrometry. Anal Chem. 2024 Jan 23; 96(3):1251-1258. PMID: 38206681.
Read at: PubMed - Published on 11/23/2023
Rahimi N, White MR, Amraei R, Lotfollahzadeh S, Xia C, Michalak M, Costello CE, Mühlberger E. Calreticulin Regulates SARS-CoV-2 Spike Protein Turnover and Modulates SARS-CoV-2 Infectivity. Cells. 2023 Nov 23; 12(23). PMID: 38067122.
Read at: PubMed - Published on 10/25/2023
Liyanage OT, Xia C, Ringler S, Stahl B, Costello CE. Defining the Ceramide Composition of Bovine and Human Milk Gangliosides by Direct Infusion ESI-CID Tandem Mass Spectrometry of Native and Permethylated Molecular Species. Anal Chem. 2023 Nov 14; 95(45):16465-16473. PMID: 37877731.
Read at: PubMed - Published on 9/1/2023
Kanjana K, Strle K, Lochhead RB, Pianta A, Mateyka LM, Wang Q, Arvikar SL, Kling DE, Deangelo CA, Curham L, Barbour AG, Costello CE, Moon JJ, Steere AC. Autoimmunity to synovial extracellular matrix proteins in patients with postinfectious Lyme arthritis. J Clin Invest. 2023 Sep 01; 133(17). PMID: 37471146.
Read at: PubMed - Published on 8/4/2023
Zhang L, Liu X, Wang X, Zhu G, Song H, Cheng R, Naowarojna N, Costello CE, Liu P. Correspondence on "Structural Insight into the Catalytic Mechanism of the Endoperoxide Synthase FtmOx1". Angew Chem Int Ed Engl. 2023 Sep 11; 62(37):e202218643. PMID: 37541669.
Read at: PubMed
View 466 more publications: View full profile at BUMC