Andrew J. Henderson, PhD

Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Research in my laboratory focuses on cellular mechanisms that regulate HIV replication and transcription. Current projects include exploring how signaling influences HIV infection and latency, devising strategies for long-term repression of HIV provirus and characterizing the transcriptional status of HIV provirus in T cell and macrophage subsets. In addition, we are interested in mechanisms that contribute to HIV associated inflammation. I have served on NIH study sections and special emphasis panels and was a member and chair for the NIH AIDS Molecular and Cellular Biology Study Section. In addition to my research, I have always been proactive in undergraduate and graduate training developing and providing leadership for PhD pipeline programs, and training international researchers.

Publications

  • Published 4/27/2026

    Leal AA, Tafrate S, He X, Bryant DL, Herring MB, Andrade M, McWhirter JB, Quiñones-Molina AA, Gummuluru S, Sagar M, Flynn RL, Leshchiner I, Henderson AJ. Bloom syndrome helicase is required for efficient HIV-1 reverse transcription in macrophages. bioRxiv. 2026 Apr 27. PMID: 42094387.

    Read at: PubMed

  • Published 4/7/2026

    Kilroy J, Deokar A, Patalano S, Bass JF, Sagar M, Gummuluru S, Henderson AJ. Intragenic Transcription from Defective HIV Proviruses Triggers Interferon Responses in Myeloid Cells. bioRxiv. 2026 Apr 07. PMID: 41993403.

    Read at: PubMed

  • Published 10/6/2025

    Skeete C, Sgambettera G, Gojanovich AD, He X, Bryant D, Yang M, Banerjee S, Quiñones-Molina AA, Akiyama H, Mostoslavsky G, Henderson AJ, Gummuluru S. Mu opioid receptor activation in microglia enhances HIV-1 infection and HIV-infection-induced inflammatory responses. Front Immunol. 2025; 16:1628872. PMID: 41122167.

    Read at: PubMed

  • Published 9/8/2025

    Jalloh S, Hughes IK, Akiyama H, Gojanovich AD, Quiñones-Molina AA, Yang M, Henderson AJ, Mostoslavsky G, Gummuluru S. Expression of intron-containing HIV-1 RNA induces NLRP1 inflammasome activation in myeloid cells. PLoS Biol. 2025 Sep; 23(9):e3003320. PMID: 40920844.

    Read at: PubMed

  • Published 8/25/2025

    Hughes IK, Kharytonchyk S, Ramaswamy S, Jalloh S, Hood JB, He X, Henderson AJ, Akiyama H, Telesnitsky A, Gummuluru S. 5' cap sequestration is required for sensing of unspliced HIV-1 RNA by MDA5. bioRxiv. 2025 Aug 25. PMID: 40909469.

    Read at: PubMed

View All 79 Publications:   View Full Profile in BUMC

Other Positions

  • Assistant Dean, Oral Health Sciences
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
  • Professor, Virology, Immunology & Microbiology
    Boston University Chobanian & Avedisian School of Medicine
  • Member, BU-BMC Cancer Center
    Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research
    Boston University
  • Member, Genome Science Institute
    Boston University
  • Graduate Medical Sciences Educator and Mentor (Primary Mentor of Graduate Students)
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
  • Co-Director, Clinical and Translational Science Institute
    Boston University

Websites

Education

  • University of California, Riverside, PhD
  • University of California, Riverside, MS
  • University of California, Riverside, BS

View all profiles