My research focuses on the molecular regulation of progenitor cell fate and morphogenesis in the developing lung and the contribution of developmental signals in lung regeneration and repair mechanisms. Over more than a decade my laboratory investigates the role of developmental pathways, including retinoic acid, Fgfs and Notch, in the establishment of cell fate and patterning of the embryonic lung. These studies have provided insights into specific gene regulatory networks that control induction of the lung primordium, airway branching and differentiation. Currently I direct a Program in Lung Developmental Biology at the Pulmonary Center BUSM, which congregates investigators with knowledge in lung morphogenesis, stem cell biology and regenerative medicine. The overall goals of this Program are to elucidate the properties and fates of lung progenitor cells, to develop tools for their characterization, and to understand the genetic and epigenetic mechanisms that control lineage as the lung forms. Interactions with this group have led to exciting collaborations and exchange of ideas and technologies.
- Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences
- Professor, Pathology & Laboratory Medicine, Boston University School of Medicine
- Universidade de Brasília, MD
- Universidade de São Paulo, PhD
- Published on 4/3/2019
van Soldt BJ, Qian J, Li J, Tang N, Lu J, Cardoso WV. Yap and its subcellular localization have distinct compartment-specific roles in the developing lung. Development. 2019 Apr 03. PMID: 30944105.
- Published on 11/19/2018
Mori M, Hazan R, Danielian PS, Mahoney JE, Li H, Lu J, Miller ES, Zhu X, Lees JA, Cardoso WV. Author Correction: Cytoplasmic E2f4 forms organizing centres for initiation of centriole amplification during multiciliogenesis. Nat Commun. 2018 11 19; 9:16157. PMID: 30451964.
- Published on 10/30/2018
Qiu H, Shi S, Yue J, Xin M, Nairn AV, Lin L, Liu X, Li G, Archer-Hartmann SA, Dela Rosa M, Galizzi M, Wang S, Zhang F, Azadi P, van Kuppevelt TH, Cardoso WV, Kimata K, Ai X, Moremen KW, Esko JD, Linhardt RJ, Wang L. A mutant-cell library for systematic analysis of heparan sulfate structure-function relationships. Nat Methods. 2018 Nov; 15(11):889-899. PMID: 30377379.
- Published on 9/20/2018
Zhang Y, Yang Y, Jiang M, Huang SX, Zhang W, Al Alam D, Danopoulos S, Mori M, Chen YW, Balasubramanian R, Chuva de Sousa Lopes SM, Serra C, Bialecka M, Kim E, Lin S, Toste de Carvalho ALR, Riccio PN, Cardoso WV, Zhang X, Snoeck HW, Que J. 3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling. Cell Stem Cell. 2018 Oct 04; 23(4):516-529.e5. PMID: 30244870.
- Published on 6/5/2018
de Barros Mendes Lopes T, Groth EE, Veras M, Furuya TK, de Souza Xavier Costa N, Ribeiro Júnior G, Lopes FD, de Almeida FM, Cardoso WV, Saldiva PHN, Chammas R, Mauad T. Pre- and postnatal exposure of mice to concentrated urban PM2.5 decreases the number of alveoli and leads to altered lung function at an early stage of life. Environ Pollut. 2018 Oct; 241:511-520. PMID: 29883952.
- Published on 5/3/2018
Yang Y, Cardoso WV. Stem Cells Sheltered from Air-Raids Repair Airways. Cell Stem Cell. 2018 05 03; 22(5):613-614. PMID: 29727674.
- Published on 3/26/2018
Yang Y, Riccio P, Schotsaert M, Mori M, Lu J, Lee DK, García-Sastre A, Xu J, Cardoso WV. Spatial-Temporal Lineage Restrictions of Embryonic p63+ Progenitors Establish Distinct Stem Cell Pools in Adult Airways. Dev Cell. 2018 03 26; 44(6):752-761.e4. PMID: 29587145.
- Published on 1/16/2018
Smith BM, Traboulsi H, Austin JHM, Manichaikul A, Hoffman EA, Bleecker ER, Cardoso WV, Cooper C, Couper DJ, Dashnaw SM, Guo J, Han MK, Hansel NN, Hughes EW, Jacobs DR, Kanner RE, Kaufman JD, Kleerup E, Lin CL, Liu K, Lo Cascio CM, Martinez FJ, Nguyen JN, Prince MR, Rennard S, Rich SS, Simon L, Sun Y, Watson KE, Woodruff PG, Baglole CJ, Barr RG. Human airway branch variation and chronic obstructive pulmonary disease. Proc Natl Acad Sci U S A. 2018 01 30; 115(5):E974-E981. PMID: 29339516.
- Published on 7/4/2017
Mori M, Hazan R, Danielian PS, Mahoney JE, Li H, Lu J, Miller ES, Zhu X, Lees JA, Cardoso WV. Cytoplasmic E2f4 forms organizing centres for initiation of centriole amplification during multiciliogenesis. Nat Commun. 2017 07 04; 8:15857. PMID: 28675157.
- Published on 5/19/2017
Stupnikov MR, Cardoso WV. Sensing oxygen inside and out. Elife. 2017 May 19; 6. PMID: 28525315.
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