Weiming Xia, PhD
Professor, Pharmacology & Experimental Therapeutics
Biography
Dr. Xia completed his graduate studies at the University of Texas Medical School at Houston where he earned his MS and PhD degrees (Biochemistry and Molecular Biology). He completed his postdoctoral training in Alzheimer’s disease (AD) at Brigham and Women’s Hospital, Harvard Medical School. In 1999 he became Assistant Professor of Neurology at Harvard Medical School and established a NIH-funded research lab to study AD. In 2012 he joined Department of Veterans Affairs Bedford VA Medical Center, and he leads an independent lab to explore molecular mechanism and biomarkers for AD.
Dr. Xia’s research interests involve target identification, characterization, validation and early stage drug development, with exploration of clinical biomarkers for AD. He has established multiple platforms to quantify pathological proteins like amyloid ß protein (Aß), Tau, neuroinflammatory factors, and related biomarkers. He also develops Mass Spectrometry-based analytic approaches to explore biomarkers for AD and other central nervous system disorders.
Other Positions
- Bedford VA - Edith Nourse Rogers Memorial VA Hosp
Education
- University of Texas Health Science Center at Houston, PhD
- University of Texas Health Science Center at Houston, MS
- Fudan University, BS
Publications
- Published on 4/17/2020
Muraoka S, DeLeo AM, Sethi MK, Yukawa-Takamatsu K, Yang Z, Ko J, Hogan JD, Ruan Z, You Y, Wang Y, Medalla M, Ikezu S, Chen M, Xia W, Gorantla S, Gendelman HE, Issadore D, Zaia J, Ikezu T. Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues. Alzheimers Dement. 2020 06; 16(6):896-907. PMID: 32301581.
Read at: PubMed - Published on 2/19/2020
Friedberg JS, Aytan N, Cherry JD, Xia W, Standring OJ, Alvarez VE, Nicks R, Svirsky S, Meng G, Jun G, Ryu H, Au R, Stein TD. Associations between brain inflammatory profiles and human neuropathology are altered based on apolipoprotein E e4 genotype. Sci Rep. 2020 02 19; 10(1):2924. PMID: 32076055.
Read at: PubMed - Published on 2/5/2020
Muraoka S, Lin W, Chen M, Hersh SW, Emili A, Xia W, Ikezu T. Assessment of separation methods for extracellular vesicles from human and mouse brain tissues and human cerebrospinal fluids. Methods. 2020 05 01; 177:35-49. PMID: 32035230.
Read at: PubMed - Published on 1/1/2020
Chen M, Xia W. Proteomic Profiling of Plasma and Brain Tissue from Alzheimer's Disease Patients Reveals Candidate Network of Plasma Biomarkers. J Alzheimers Dis. 2020; 76(1):349-368. PMID: 32474469.
Read at: PubMed - Published on 6/10/2019
Standring OJ, Friedberg J, Tripodis Y, Chua AS, Cherry JD, Alvarez VE, Huber BR, Xia W, Mez J, Alosco ML, Nicks R, Mahar I, Pothast MJ, Gardner HM, Meng G, Palmisano JN, Martin BM, Dwyer B, Kowall NW, Cantu RC, Goldstein LE, Katz DI, Stern RA, McKee AC, Stein TD. Contact sport participation and chronic traumatic encephalopathy are associated with altered severity and distribution of cerebral amyloid angiopathy. Acta Neuropathol. 2019 09; 138(3):401-413. PMID: 31183671.
Read at: PubMed - Published on 2/11/2019
Xia W. ?-Secretase and its modulators: Twenty years and beyond. Neurosci Lett. 2019 05 14; 701:162-169. PMID: 30763650.
Read at: PubMed - Published on 1/1/2019
Wright LM, Stein TD, Jun G, Chung J, McConnell K, Fiorello M, Siegel N, Ness S, Xia W, Turner KL, Subramanian ML. Association of Cognitive Function with Amyloid-ß and Tau Proteins in the Vitreous Humor. J Alzheimers Dis. 2019; 68(4):1429-1438. PMID: 30856114.
Read at: PubMed - Published on 1/1/2019
Chen CD, Zeldich E, Khodr C, Camara K, Tung TY, Lauder EC, Mullen P, Polanco TJ, Liu YY, Zeldich D, Xia W, Van Nostrand WE, Brown LE, Porco JA, Abraham CR. Small Molecule Amyloid-ß Protein Precursor Processing Modulators Lower Amyloid-ß Peptide Levels via cKit Signaling. J Alzheimers Dis. 2019; 67(3):1089-1106. PMID: 30776010.
Read at: PubMed - Published on 4/27/2018
Chen M, Lee HK, Moo L, Hanlon E, Stein T, Xia W. Common proteomic profiles of induced pluripotent stem cell-derived three-dimensional neurons and brain tissue from Alzheimer patients. J Proteomics. 2018 06 30; 182:21-33. PMID: 29709615.
Read at: PubMed - Published on 1/1/2018
Chen M, Song H, Cui J, Johnson CE, Hubler GK, DePalma RG, Gu Z, Xia W. Proteomic Profiling of Mouse Brains Exposed to Blast-Induced Mild Traumatic Brain Injury Reveals Changes in Axonal Proteins and Phosphorylated Tau. J Alzheimers Dis. 2018; 66(2):751-773. PMID: 30347620.
Read at: PubMed
View 99 more publications: View full profile at BUMC