My primary research interests involve the investigation of the recovery of fine motor function and re-organization of the motor cortex following cortical injury. Using a non-human primate (NHP) model of cortical injury developed with Dr. Rosene, we are establishing the rate and pattern of recovery of fine motor function of the hand and the histopathological response of the brain to injury in this model with young and aged NHPs. Additional studies with this model include assessing the efficacy of various therapeutics to enhance the recovery of function following ischemia.
In addition, we are conducting studies with Pfizer, Inc to assess the efficacy of various pharmaceutical therapies for slowing or reversing age-related cognitive decline in non-human primates.
Finally, as part of my role as director of the MS in Forensic Anthropology I also participate in studies of the rate and process of decomposition in a cold climate using a porcine model.
- Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Division of Graduate Medical Sciences
- Associate Professor, Neurology, Boston University School of Medicine
- Boston University School of Medicine, PhD
- Univ Calgary, BA
- Published on 7/4/2018
Koo BB, Calderazzo S, Bowley BGE, Kolli A, Moss MB, Rosene DL, Moore TL. Long-term effects of curcumin in the non-human primate brain. Brain Res Bull. 2018 Jul 04; 142:88-95. PMID: 29981358.
- Published on 5/1/2018
Mella M, Schweitzer B, Mallet CR, Moore T, Botch-Jones S. Detection of Cocaine and Metabolites in Bone Following Decomposition Using 2D LC-MS-MS. J Anal Toxicol. 2018 May 01; 42(4):265-275. PMID: 29300918.
- Published on 3/11/2018
Orczykowski ME, Arndt KR, Palitz LE, Kramer BC, Pessina MA, Oblak AL, Finklestein SP, Mortazavi F, Rosene DL, Moore TL. Cell based therapy enhances activation of ventral premotor cortex to improve recovery following primary motor cortex injury. Exp Neurol. 2018 Jul; 305:13-25. PMID: 29540323.
- Published on 2/21/2018
Berger JM, Pokines JT, Moore TL. Analysis of Class Characteristics of Reciprocating Saws. J Forensic Sci. 2018 Feb 21. PMID: 29464701.
- Published on 2/15/2018
Moore TL, Bowley BGE, Shultz PL, Calderazzo SM, Shobin EJ, Uprety AR, Rosene DL, Moss MB. Oral curcumin supplementation improves fine motor function in the middle-aged rhesus monkey. Somatosens Mot Res. 2018 Mar; 35(1):1-10. PMID: 29447046.
- Published on 10/18/2017
Moore TL, Bowley B, Shultz P, Calderazzo S, Shobin E, Killiany RJ, Rosene DL, Moss MB. Chronic curcumin treatment improves spatial working memory but not recognition memory in middle-aged rhesus monkeys. Geroscience. 2017 12; 39(5-6):571-584. PMID: 29047012.
- Published on 2/25/2017
Shobin E, Bowley MP, Estrada LI, Heyworth NC, Orczykowski ME, Eldridge SA, Calderazzo SM, Mortazavi F, Moore TL, Rosene DL. Microglia activation and phagocytosis: relationship with aging and cognitive impairment in the rhesus monkey. Geroscience. 2017 Apr; 39(2):199-220. PMID: 28238188.
- Published on 2/2/2017
Santana SA, Bethard JD, Moore TL. Accuracy of Dental Age in Nonadults: A Comparison of Two Methods for Age Estimation Using Radiographs of Developing Teeth. J Forensic Sci. 2017 Sep; 62(5):1320-1325. PMID: 28150395.
- Published on 11/16/2016
Newcomb AM, Pokines JT, Moore TL. Taphonomic Effects of Mechanical Plowing on Buried Juvenile-Sized Remains. J Forensic Sci. 2017 01; 62(1):67-73. PMID: 27864968.
- Published on 11/11/2016
Pokines JT, Sussman R, Gough M, Ralston C, McLeod E, Brun K, Kearns A, Moore TL. Taphonomic Analysis of Rodentia and Lagomorpha Bone Gnawing Based Upon Incisor Size. J Forensic Sci. 2017 01; 62(1):50-66. PMID: 27859293.
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