My primary research interests involve the investigation of the recovery of fine motor function and re-organization of the motor cortex following cortical injury. Using a non-human primate (NHP) model of cortical injury developed with Dr. Rosene, we are establishing the rate and pattern of recovery of fine motor function of the hand and the histopathological response of the brain to injury in this model with young and aged NHPs. Additional studies with this model include assessing the efficacy of various therapeutics to enhance the recovery of function following ischemia.
In addition, we are conducting studies with Pfizer, Inc to assess the efficacy of various pharmaceutical therapies for slowing or reversing age-related cognitive decline in non-human primates.
Finally, as part of my role as director of the MS in Forensic Anthropology I also participate in studies of the rate and process of decomposition in a cold climate using a porcine model.
- Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Division of Graduate Medical Sciences
- Associate Professor, Neurology, Boston University School of Medicine
- Boston University School of Medicine, PhD
- Univ Calgary, BA
- Published on 10/18/2017
Moore TL, Bowley B, Shultz P, Calderazzo S, Shobin E, Killiany RJ, Rosene DL, Moss MB. Chronic curcumin treatment improves spatial working memory but not recognition memory in middle-aged rhesus monkeys. Geroscience. 2017 Oct 18. PMID: 29047012.
- Published on 2/25/2017
Shobin E, Bowley MP, Estrada LI, Heyworth NC, Orczykowski ME, Eldridge SA, Calderazzo SM, Mortazavi F, Moore TL, Rosene DL. Microglia activation and phagocytosis: relationship with aging and cognitive impairment in the rhesus monkey. Geroscience. 2017 Apr; 39(2):199-220. PMID: 28238188.
- Published on 2/2/2017
Santana SA, Bethard JD, Moore TL. Accuracy of Dental Age in Nonadults: A Comparison of Two Methods for Age Estimation Using Radiographs of Developing Teeth. J Forensic Sci. 2017 Sep; 62(5):1320-1325. PMID: 28150395.
- Published on 11/16/2016
Newcomb AM, Pokines JT, Moore TL. Taphonomic Effects of Mechanical Plowing on Buried Juvenile-Sized Remains. J Forensic Sci. 2017 01; 62(1):67-73. PMID: 27864968.
- Published on 11/11/2016
Pokines JT, Sussman R, Gough M, Ralston C, McLeod E, Brun K, Kearns A, Moore TL. Taphonomic Analysis of Rodentia and Lagomorpha Bone Gnawing Based Upon Incisor Size. J Forensic Sci. 2017 01; 62(1):50-66. PMID: 27859293.
- Published on 9/21/2016
Moore TL, Pessina MA, Finklestein SP, Killiany RJ, Bowley B, Benowitz L, Rosene DL. Inosine enhances recovery of grasp following cortical injury to the primary motor cortex of the rhesus monkey. Restor Neurol Neurosci. 2016 Sep 21; 34(5):827-48. PMID: 27497459.
- Published on 7/14/2015
Ngwenya LB, Heyworth NC, Shwe Y, Moore TL, Rosene DL. Age-related changes in dentate gyrus cell numbers, neurogenesis, and associations with cognitive impairments in the rhesus monkey. Front Syst Neurosci. 2015; 9:102. PMID: 26236203.
- Published on 6/12/2013
Moore TL, Pessina MA, Finklestein SP, Kramer BC, Killiany RJ, Rosene DL. Recovery of fine motor performance after ischemic damage to motor cortex is facilitated by cell therapy in the rhesus monkey. Somatosens Mot Res. 2013 Dec; 30(4):185-96. PMID: 23758412.
- Published on 10/22/2012
Moore TL, Schettler SP, Killiany RJ, Rosene DL, Moss MB. Impairment in delayed nonmatching to sample following lesions of dorsal prefrontal cortex. Behav Neurosci. 2012 Dec; 126(6):772-80. PMID: 23088539.
- Published on 4/1/2011
Moore TL, Killiany RJ, Pessina MA, Moss MB, Finklestein SP, Rosene DL. Recovery from ischemia in the middle-aged brain: a nonhuman primate model. Neurobiol Aging. 2012 Mar; 33(3):619.e9-619.e24. PMID: 21458887.
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