Shuaiying Cui, PhD

Associate Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Dr. Cui's research has focused on the development of novel agents that can elicit developmental stage-specific gene silencing or reprogramming in hematopoietic stem cells and progenitors through a series of epigenetic chromatin modifications by nucleosome remodeling, histone deacetylation and demethylation. Such agents can be applied to the treatment of the patients with hematologic disorders such as sickle cell disease and beta-thalassemia, as well as acute myeloid leukemia (Blood cancer), which arise from congenital defects in genome. The findings from these preclinical studies could also help to establish therapeutic indications in other hematological malignancies.

Publications

  • Published 6/23/2026

    Benmhammed H, Sun Y, AlAbdullatif S, Chen A, Khan S, Zadeh AM, Mazile N, Beacham GM, Mahdaviani K, Williams C, Alekseyev YO, Campbell JD, Hagedorn EJ, Heaphy C, Klings ES, Steinberg MH, Cui S. PGC-1a agonism via oral administration of ZLN005 induces fetal hemoglobin and is antisickling in sickle mice. Blood Adv. 2026 Jun 23; 10(12):4358-4369. PMID: 42024469.

    Read at: PubMed

  • Published 7/31/2024

    Sun Y, Benmhammed H, Al Abdullatif S, Habara A, Fu E, Brady J, Williams C, Ilinski A, Sharma A, Mahdaviani K, Alekseyev YO, Campbell JD, Steinberg MH, Cui S. PGC-1a agonism induces fetal hemoglobin and exerts antisickling effects in sickle cell disease. Sci Adv. 2024 Aug 02; 10(31):eadn8750. PMID: 39083598.

    Read at: PubMed

  • Published 4/27/2024

    Myers G, Sun Y, Wang Y, Benmhammed H, Cui S. Roles of Nuclear Orphan Receptors TR2 and TR4 during Hematopoiesis. Genes (Basel). 2024 Apr 27; 15(5). PMID: 38790192.

    Read at: PubMed

  • Published 2/4/2022

    Sun Y, Habara A, Le CQ, Nguyen N, Chen R, Murphy GJ, Chui DHK, Steinberg MH, Cui S. Pharmacologic induction of PGC-1a stimulates fetal haemoglobin gene expression. Br J Haematol. 2022 Apr; 197(1):97-109. PMID: 35118652.

    Read at: PubMed

  • Published 1/26/2022

    Aygun B, Bello A, Thompson AA, Davis L, Sun Y, Luo HY, Cui S, Chui DHK. Clinical phenotypes of three children with sickle cell disease caused by HbS/Sicilian (dß)0 -thalassemia deletion. Am J Hematol. 2022 04; 97(4):E156-E158. PMID: 35045200.

    Read at: PubMed

View All 28 Publications:   View Full Profile in BUMC

Other Positions

  • Member, Center for Excellence in Sickle Cell Disease
    Boston University

Websites

Education

  • University of Science and Technology of China, PhD
  • Anhui University, BS

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