Shinobu Matsuura, DVM, PhD

Assistant Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

My career goal is to apply my knowledge in veterinary medicine to most effectively use animal models to develop therapies that can significant translational potential and potential to impact patient outcomes. I have a career-long interest in hematology research, which emerged from my experience treating canine patients with hematological malignancies. My major research focus is hematopoietic stem cell biology and the de-regulation of those processes in malignancy. My current project explores the potential to target stem cells in myeloproliferative neoplasms driven by the JAK2V617F mutation through integrins. Given the experience accumulated on therapeutic targeting of integrins, I am excited by the significant translational potential of this project.

I graduated School of Veterinary Medicine and completed Residency in Internal Medicine at the University of São Paulo (USP), Brazil. My training in research consists of a graduate degree at the University of Tokyo, Japan, under the guidance of Dr. Hajime Tsujimoto, and postdoctoral training at the laboratories of Dr. Dong-Er Zhang at the Scripps Research Institute and at the University of California, San Diego under a F32 award, and Dr. Katya Ravid at Boston University. I was promoted Instructor of Medicine at the Boston University Chobanian and Avedisian School of Medicine in 2016 and Assistant Professor in 2021. I am a PI of the career development SERCA K01 award, from the Office of Research Infrastructure (ORIP)/NIH, a training mechanism specifically designed for veterinarians pursuing basic research.

Publications

  • Published 6/20/2024

    Karagianni A, Karkempetzaki AI, Brooks D, Matsuura S, Dambal V, Trackman PC, Ravid K. Deletion of mouse lysyl oxidase in megakaryocytes affects bone properties in a sex-dependent manner. Blood. 2024 Jun 20; 143(25):2666-2670. PMID: 38635757.

    Read at: PubMed

  • Published 6/10/2024

    Arimoto KI, Zhang Y, Matsuura S, Miyauchi S, Zhang DE. Hypersensitivity to type I interferon as a cause of hydrocephalus development. Brain Res. 2024 Oct 01; 1840:149082. PMID: 38866307.

    Read at: PubMed

  • Published 1/2/2024

    Abbonante V, Karkempetzaki AI, Leon C, Krishnan A, Huang N, Di Buduo CA, Cattaneo D, Ward CM, Matsuura S, Guinard I, Weber J, De Acutis A, Vozzi G, Iurlo A, Ravid K, Balduini A. Newly identified roles for PIEZO1 mechanosensor in controlling normal megakaryocyte development and in primary myelofibrosis. Am J Hematol. 2024 Mar; 99(3):336-349. PMID: 38165047.

    Read at: PubMed

  • Published 7/8/2022

    Karagianni A, Matsuura S, Gerstenfeld LC, Ravid K. Inhibition of Osteoblast Differentiation by JAK2V617F Megakaryocytes Derived From Male Mice With Primary Myelofibrosis. Front Oncol. 2022; 12:929498. PMID: 35880162.

    Read at: PubMed

  • Published 12/21/2021

    Matsuura S, Balduini A, Onisto M. Editorial: Mechanisms of Cell Adhesion in Hematopoietic Stem Cells. Front Cell Dev Biol. 2021; 9:826554. PMID: 34993206.

    Read at: PubMed

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Websites

Education

  • University of Tokyo, PhD
  • Universidade de São Paulo, DVM

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