Shinobu Matsuura, DVM, PhD

Assistant Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

My major research focus is hematopoietic stem cell (HSC) biology and processes that lead to its de-regulation in malignancy. My knowledge and expertise in veterinary medicine allows me to most effectively use animal models for research that have significant translational potential. My current project focus is myeloproliferative neoplasm stem cells driven by the JAK2V617F mutation. We perform in-depth phenotyping of HSC using analytical flow cytometry, transcriptomics, in vivo functional studies using bone marrow transplantation, and in vitro studies of primary HSCs. Through those studies, we aim to uncover the HSC defects that characterize this pre-malignant disease, and understand the process of transformation from normal to the malignant state.

Publications

  • Published 6/20/2024

    Karagianni A, Karkempetzaki AI, Brooks D, Matsuura S, Dambal V, Trackman PC, Ravid K. Deletion of mouse lysyl oxidase in megakaryocytes affects bone properties in a sex-dependent manner. Blood. 2024 Jun 20; 143(25):2666-2670. PMID: 38635757.

    Read at: PubMed

  • Published 6/10/2024

    Arimoto KI, Zhang Y, Matsuura S, Miyauchi S, Zhang DE. Hypersensitivity to type I interferon as a cause of hydrocephalus development. Brain Res. 2024 Oct 01; 1840:149082. PMID: 38866307.

    Read at: PubMed

  • Published 1/2/2024

    Abbonante V, Karkempetzaki AI, Leon C, Krishnan A, Huang N, Di Buduo CA, Cattaneo D, Ward CM, Matsuura S, Guinard I, Weber J, De Acutis A, Vozzi G, Iurlo A, Ravid K, Balduini A. Newly identified roles for PIEZO1 mechanosensor in controlling normal megakaryocyte development and in primary myelofibrosis. Am J Hematol. 2024 Mar; 99(3):336-349. PMID: 38165047.

    Read at: PubMed

  • Published 7/8/2022

    Karagianni A, Matsuura S, Gerstenfeld LC, Ravid K. Inhibition of Osteoblast Differentiation by JAK2V617F Megakaryocytes Derived From Male Mice With Primary Myelofibrosis. Front Oncol. 2022; 12:929498. PMID: 35880162.

    Read at: PubMed

  • Published 12/21/2021

    Matsuura S, Balduini A, Onisto M. Editorial: Mechanisms of Cell Adhesion in Hematopoietic Stem Cells. Front Cell Dev Biol. 2021; 9:826554. PMID: 34993206.

    Read at: PubMed

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Websites

Education

  • University of Tokyo, PhD
  • Universidade de São Paulo, DVM

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