My research is focused on clinical and translational research in vasculitis: biomarkers, genetics, and clinical trials.
I have led studies aimed at identifying new markers that could improve diagnosis, staging, assessment of current disease activity, and predicting the future course of disease, using proteins detectable in the blood or urine and gene expression profiles in blood cells.
I have also led candidate genes studies in vasculitis and has been involved in the planning and recruitment for genome-wide association studies in multiple forms of vasculitis.
I have participated in most multi-center clinical trials conducted over the past 10 years in the US, in various vasculitides.
This work has been conducted through NIH-funded consortia: the Vasculitis Clinical Research Consortium and the RAVE/ITN Study Group. In addition, I have been a member of the Immunological Genome Project Consortium and contributed data on gene expression in mouse neutrophils to that effort.
- University of Chicago, MD
- University of Chicago, PhD
- Harvard University, AB
- Published on 10/31/2018
Moran SM, Monach PA, Zgaga L, Cuthbertson D, Carette S, Khalidi NA, Koening CL, Langford CA, McAlear CA, Moreland L, Pagnoux C, Seo P, Specks U, Sreih A, Wyse J, Ytterberg SR, Merkel PA, Little MA. Urinary soluble CD163 and monocyte chemoattractant protein-1 in the identification of subtle renal flare in anti-neutrophil cytoplasmic antibody-associated vasculitis. Nephrol Dial Transplant. 2018 Oct 31. PMID: 30380100.
- Published on 10/22/2018
Sreih AG, Ezzedine R, Leng L, Fan J, Yao J, Reid D, Piecychna M, Carette S, Cuthbertson D, Dellaripa P, Hoffman GS, Khalidi NA, Koening CL, Langford CA, Mahr A, McAlear CA, Maksimowicz-Mckinnon K, Monach PA, Seo P, Specks U, St Clair EW, Stone JH, Ytterberg SR, Edberg J, Merkel PA, Bucala R. Role of Macrophage Migration Inhibitory Factor in Granulomatosis With Polyangiitis. Arthritis Rheumatol. 2018 Dec; 70(12):2077-2086. PMID: 29953750.
- Published on 10/21/2018
Conklin LS, Merkel PA, Pachman LM, Parikh H, Tawalbeh S, Damsker JM, Cuthbertson DD, Morgan GA, Monach PA, Hathout Y, Nagaraju K, van den Anker J, McAlear CA, Hoffman EP. Serum biomarkers of glucocorticoid response and safety in anti-neutrophil cytoplasmic antibody-associated vasculitis and juvenile dermatomyositis. Steroids. 2018 Dec; 140:159-166. PMID: 30352204.
- Published on 10/11/2018
Rhee RL, Holweg CTJ, Wong K, Cuthbertson D, Carette S, Khalidi NA, Koening CL, Langford CA, McAlear CA, Monach PA, Moreland LW, Pagnoux C, Seo P, Specks U, Sreih AG, Ytterberg SR, Merkel PA. Serum periostin as a biomarker in eosinophilic granulomatosis with polyangiitis. PLoS One. 2018; 13(10):e0205768. PMID: 30308057.
- Published on 10/1/2018
Springer JM, Monach P, Cuthbertson D, Carette S, Khalidi NA, McAlear CA, Pagnoux C, Seo P, Warrington KJ, Ytterberg SR, Hoffman G, Langford C, Hamilton T, Foell D, Vogl T, Holzinger D, Merkel PA, Roth J, Hajj-Ali RA. Serum S100 Proteins as a Marker of Disease Activity in Large Vessel Vasculitis. J Clin Rheumatol. 2018 Oct; 24(7):393-395. PMID: 29470262.
- Published on 5/9/2018
Kermani TA, Diab S, Sreih AG, Cuthbertson D, Borchin R, Carette S, Forbess L, Koening CL, McAlear CA, Monach PA, Moreland L, Pagnoux C, Seo P, Spiera RF, Warrington KJ, Ytterberg SR, Langford CA, Merkel PA, Khalidi NA. Arterial lesions in giant cell arteritis: A longitudinal study. Semin Arthritis Rheum. 2018 May 09. PMID: 29880442.
- Published on 5/7/2018
Berti A, Warner R, Johnson K, Cornec D, Schroeder D, Kabat B, Langford CA, Hoffman GS, Fervenza FC, Kallenberg CGM, Seo P, Spiera R, St Clair EW, Brunetta P, Stone JH, Merkel PA, Specks U, Monach PA. Brief Report: Circulating Cytokine Profiles and Antineutrophil Cytoplasmic Antibody Specificity in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. Arthritis Rheumatol. 2018 Jul; 70(7):1114-1121. PMID: 29693324.
- Published on 4/1/2018
Cornec D, Kabat BF, Mills JR, Cheu M, Hummel AM, Schroeder DR, Cascino MD, Brunetta P, Murray DL, Snyder MR, Fervenza F, Hoffman GS, Kallenberg CGM, Langford CA, Merkel PA, Monach PA, Seo P, Spiera RF, St Clair EW, Stone JH, Barnidge DR, Specks U. Pharmacokinetics of rituximab and clinical outcomes in patients with anti-neutrophil cytoplasmic antibody associated vasculitis. Rheumatology (Oxford). 2018 04 01; 57(4):639-650. PMID: 29340623.
- Published on 2/1/2018
Kermani TA, Sreih AG, Cuthbertson D, Carette S, Hoffman GS, Khalidi NA, Koening CL, Langford CA, McAlear CA, Monach PA, Moreland L, Pagnoux C, Seo P, Warrington KJ, Ytterberg SR, Merkel PA. Evaluation of damage in giant cell arteritis. Rheumatology (Oxford). 2018 02 01; 57(2):322-328. PMID: 29112740.
- Published on 1/25/2018
Rhee RL, Davis JC, Ding L, Fervenza FC, Hoffman GS, Kallenberg CGM, Langford CA, McCune WJ, Monach PA, Seo P, Spiera R, St Clair EW, Specks U, Stone JH, Merkel PA. The Utility of Urinalysis in Determining the Risk of Renal Relapse in ANCA-Associated Vasculitis. Clin J Am Soc Nephrol. 2018 Feb 07; 13(2):251-257. PMID: 29371340.
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