Nicholas A. Crossland, DVM, DACVP

Assistant Professor, Pathology & Laboratory Medicine

Nicholas Crossland
617.358.9285
620 Albany Street

Biography

Dr. Crossland is a board certified Veterinary Anatomic Pathologist. He shares a dual appointment as an Assistant Professor in the Department of Pathology and Laboratory Medicine at Boston University School of Medicine and an Investigator at the NEIDL. His primary responsibility is managing an experimental comparative pathology service that safely and efficiently operates in biosafety levels 3 and 4 (BSL3/4). His specialization is in characterization of translational animal models to elcudidate our understanding of pathogenesis and serve as a platform for evaluating medical counter measures. His lab space is also open to graduate students from the Pathology and Laboratory Medicine Department where he provides mentorship in the development and optimization of multiplex immunohistochemistry and in situ hybridization techniques to answer biological questions with retention of spatial context. He is actively exploring collaborative opportunities with other BUMC faculty members to develop and validate deep learning computational approaches to quantitatively characterize morphomolecular signatures of disease and correlate findings with clinical datasets.

Other Positions

  • Faculty, National Emerging Infectious Disease Lab, Boston University
  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences

Education

  • Kansas State University, DVM
  • Kansas State University, BS

Publications

  • Published on 9/15/2021

    Yin JH, Crossland N, Rinaldi M, Williams SM, Wakamatsu N. Pathology in Practice. J Am Vet Med Assoc. 2021 09 15; 259(6):609-612. PMID: 34448605.

    Read at: PubMed
  • Published on 9/9/2021

    Chen DY, Khan N, Close BJ, Goel RK, Blum B, Tavares AH, Kenney D, Conway HL, Ewoldt JK, Chitalia VC, Crossland NA, Chen CS, Kotton DN, Baker SC, Fuchs SY, Connor JH, Douam F, Emili A, Saeed M. SARS-CoV-2 Disrupts Proximal Elements in the JAK-STAT Pathway. J Virol. 2021 09 09; 95(19):e0086221. PMID: 34260266.

    Read at: PubMed
  • Published on 9/1/2021

    Yen HL, Valkenburg S, Sia SF, Choy KT, Peiris JSM, Wong KHM, Crossland N, Douam F, Nicholls JM. Cellular tropism of SARS-CoV-2 in the respiratory tract of Syrian hamsters and B6.Cg-Tg(K18-ACE2)2Prlmn/J transgenic mice. Vet Pathol. 2021 Sep 01; 3009858211043084. PMID: 34467820.

    Read at: PubMed
  • Published on 6/15/2021

    Jaleel Z, Blasberg E, Troiano C, Montanaro P, Mazzilli S, Gertje HP, Crossland NA, Platt M, Spiegel J. Association of vaping with decreased vascular endothelial growth factor expression and decreased microvessel density in cutaneous wound healing tissue in rats. Wound Repair Regen. 2021 Nov; 29(6):1024-1034. PMID: 34129265.

    Read at: PubMed
  • Published on 6/1/2021

    Barker KA, Etesami NS, Shenoy AT, Arafa EI, Lyon de Ana C, Smith NM, Martin IM, Goltry WN, Barron AM, Browning JL, Kathuria H, Belkina AC, Guillon A, Zhong X, Crossland NA, Jones MR, Quinton LJ, Mizgerd JP. Lung-resident memory B cells protect against bacterial pneumonia. J Clin Invest. 2021 06 01; 131(11). PMID: 34060477.

    Read at: PubMed
  • Published on 5/26/2021

    Nambulli S, Xiang Y, Tilston-Lunel NL, Rennick LJ, Sang Z, Klimstra WB, Reed DS, Crossland NA, Shi Y, Duprex WP. Inhalable Nanobody (PiN-21) prevents and treats SARS-CoV-2 infections in Syrian hamsters at ultra-low doses. Sci Adv. 2021 05; 7(22). PMID: 34039613.

    Read at: PubMed
  • Published on 2/23/2021

    Nambulli S, Xiang Y, Tilston-Lunel NL, Rennick LJ, Sang Z, Klimstra WB, Reed DS, Crossland NA, Shi Y, Duprex WP. Inhalable Nanobody (PiN-21) prevents and treats SARS-CoV-2 infections in Syrian hamsters at ultra-low doses. bioRxiv. 2021 Feb 23. PMID: 33655253.

    Read at: PubMed
  • Published on 1/15/2021

    Carossino M, Montanaro P, O'Connell A, Kenney D, Gertje H, Grosz KA, Kurnick SA, Bosmann M, Saeed M, Balasuriya UBR, Douam F, Crossland NA. Fatal neuroinvasion of SARS-CoV-2 in K18-hACE2 mice is partially dependent on hACE2 expression. bioRxiv. 2021 Jan 15. PMID: 33469581.

    Read at: PubMed
  • Published on 10/28/2020

    Chen DY, Khan N, Close BJ, Goel RK, Blum B, Tavares AH, Kenney D, Conway HL, Ewoldt JK, Kapell S, Chitalia VC, Crossland NA, Chen CS, Kotton DN, Baker SC, Connor JH, Douam F, Emili A, Saeed M. SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAK-STAT pathway. bioRxiv. 2020 Oct 28. PMID: 33140044.

    Read at: PubMed
  • Published on 10/1/2020

    Rennick LJ, Nambulli S, Lemon K, Olinger GY, Crossland NA, Millar EL, Duprex WP. Recombinant subtype A and B human respiratory syncytial virus clinical isolates co-infect the respiratory tract of cotton rats. J Gen Virol. 2020 10; 101(10):1056-1068. PMID: 32723429.

    Read at: PubMed

View 13 more publications: View full profile at BUMC

View all profiles