Michael L Alosco, PhD

Associate Professor, Neurology

Michael Alosco
617.638.5351
72 E. Concord Street

Biography

Dr. Alosco is a licensed clinical neuropsychologist and serves as the co-director of the Boston University Alzheimer’s Disease Research Center Clinical Core and is a lead investigator of the BU CTE Center. He also oversees Neuropsychology for the Memory and Aging Clinic at Boston Medical Center. He completed his undergraduate studies at Providence College and he earned his doctoral degree in clinical psychology, with a focus on neuropsychology, in 2015 from Kent State University. He completed his clinical internship in neuropsychology at the VA Boston Healthcare System. Dr. Alosco completed his post-doctoral studies in neuropsychology via NIH-funded training Awards (T32, F32) at the Boston University Alzheimer’s Disease Research Center and CTE Center. In 2018, he became an Assistant Professor of Neurology at the Boston University School of Medicine and he was promoted to Associate Professor in 2019. Dr. Alosco has >150 peer-reviewed publications, is the PI of multiple NIH funded grants, is the recipient of an NIH/NINDS K23 Award, is the Project Lead of an NIH-funded multisite U54 grant, and serves as aco-investigator on numerous federal and non-federal funded grants. He has also written numerous book chapters, and he is the co-Editor of the Oxford Handbook of Adult Cognitive Disorders which was published by Oxford University Press in 2019.

Dr. Alosco has an active and established research program that has a thematic focus on three areas: (1) the relationship between repetitive head impacts (RHI) and traumatic brain injury (TBI) with a later-life cognitive and neuropsychiatric decline, as well as neurodegenerative disease(s); (2) the contribution of cerebrovascular disease to the clinical and neuropathological expression of CTE, AD, and AD-related dementias (ADRD); and (3) in vivo biomarker development for CTE, AD, and ADRD with a focus on tau PET imaging, structural MRI, and blood-based biomarkers.

Education

  • Kent State University, PhD
  • Kent State University, MA
  • Providence College, BA

Publications

  • Published on 8/1/2022

    Atherton K, Han X, Chung J, Cherry JD, Baucom Z, Saltiel N, Nair E, Abdolmohammadi B, Uretsky M, Khan MM, Shea C, Durape S, Martin BM, Palmisano JN, Farrell K, Nowinski CJ, Alvarez VE, Dwyer B, Daneshvar DH, Katz DI, Goldstein LE, Cantu RC, Kowall NW, Alosco ML, Huber BR, Tripodis Y, Crary JF, Farrer L, Stern RA, Stein TD, McKee AC, Mez J. Association of APOE Genotypes and Chronic Traumatic Encephalopathy. JAMA Neurol. 2022 Aug 01; 79(8):787-796. PMID: 35759276.

    Read at: PubMed
  • Published on 7/23/2022

    LeClair J, Weuve J, Fox MP, Mez J, Alosco ML, Nowinski C, McKee A, Tripodis Y. Relationship Between Level of American Football Playing and Diagnosis of Chronic Traumatic Encephalopathy in a Selection Bias Analysis. Am J Epidemiol. 2022 Jul 23; 191(8):1429-1443. PMID: 35434739.

    Read at: PubMed
  • Published on 6/20/2022

    Qiu S, Miller MI, Joshi PS, Lee JC, Xue C, Ni Y, Wang Y, De Anda-Duran I, Hwang PH, Cramer JA, Dwyer BC, Hao H, Kaku MC, Kedar S, Lee PH, Mian AZ, Murman DL, O'Shea S, Paul AB, Saint-Hilaire MH, Alton Sartor E, Saxena AR, Shih LC, Small JE, Smith MJ, Swaminathan A, Takahashi CE, Taraschenko O, You H, Yuan J, Zhou Y, Zhu S, Alosco ML, Mez J, Stein TD, Poston KL, Au R, Kolachalama VB. Multimodal deep learning for Alzheimer's disease dementia assessment. Nat Commun. 2022 Jun 20; 13(1):3404. PMID: 35725739.

    Read at: PubMed
  • Published on 5/19/2022

    Alvia M, Aytan N, Spencer KR, Foster ZW, Rauf NA, Guilderson L, Robey I, Averill JG, Walker SE, Alvarez VE, Huber BR, Mathais R, Cormier KA, Nicks R, Pothast M, Labadorf A, Agus F, Alosco ML, Mez J, Kowall NW, McKee AC, Brady CB, Stein TD. MicroRNA Alterations in Chronic Traumatic Encephalopathy and Amyotrophic Lateral Sclerosis. Front Neurosci. 2022; 16:855096. PMID: 35663558.

    Read at: PubMed
  • Published on 5/13/2022

    Morrison MS, Aparicio HJ, Blennow K, Zetterberg H, Ashton NJ, Karikari TK, Tripodis Y, Martin B, Palmisano JN, Sugarman MA, Frank B, Steinberg EG, Turk KW, Budson AE, Au R, Goldstein LE, Jun GR, Kowall NW, Killiany R, Qiu WQ, Stern RA, Mez J, McKee AC, Stein TD, Alosco ML. Antemortem plasma phosphorylated tau (181) predicts Alzheimer's disease neuropathology and regional tau at autopsy. Brain. 2022 May 13. PMID: 35554506.

    Read at: PubMed
  • Published on 4/20/2022

    Frank B, Ally M, Tripodis Y, Puzo C, Labriolo C, Hurley L, Martin B, Palmisano J, Chan L, Steinberg E, Turk K, Budson A, O'Connor M, Au R, Qiu WQ, Goldstein L, Kukull W, Kowall N, Killiany R, Stern R, Stein T, McKee A, Mez J, Alosco M. Trajectories of Cognitive Decline in Brain Donors With Autopsy-Confirmed Alzheimer Disease and Cerebrovascular Disease. Neurology. 2022 Jun 14; 98(24):e2454-e2464. PMID: 35444054.

    Read at: PubMed
  • Published on 4/1/2022

    Phelps A, Alosco ML, Baucom Z, Hartlage K, Palmisano JN, Weuve J, Mez J, Tripodis Y, Stern RA. Association of Playing College American Football With Long-term Health Outcomes and Mortality. JAMA Netw Open. 2022 Apr 01; 5(4):e228775. PMID: 35442450.

    Read at: PubMed
  • Published on 2/9/2022

    Turk KW, Geada A, Alvarez VE, Xia W, Cherry JD, Nicks R, Meng G, Daley S, Tripodis Y, Huber BR, Budson AE, Dwyer B, Kowall NW, Cantu RC, Goldstein LE, Katz DI, Stern RA, Alosco ML, Mez J, McKee AC, Stein TD. A comparison between tau and amyloid-ß cerebrospinal fluid biomarkers in chronic traumatic encephalopathy and Alzheimer disease. Alzheimers Res Ther. 2022 02 09; 14(1):28. PMID: 35139894.

    Read at: PubMed
  • Published on 1/21/2022

    Daneshvar DH, Alosco ML. In search of cost-effective and non-invasive biomarkers of traumatic brain injury. EBioMedicine. 2022 Feb; 76:103823. PMID: 35074628.

    Read at: PubMed
  • Published on 1/1/2022

    Fang Y, Doyle MF, Alosco ML, Mez J, Satizabal CL, Qiu WQ, Lunetta KL, Murabito JM. Cross-Sectional Association Between Blood Cell Phenotypes, Cognitive Function, and Brain Imaging Measures in the Community-Based Framingham Heart Study. J Alzheimers Dis. 2022; 87(3):1291-1305. PMID: 35431244.

    Read at: PubMed

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