Mark W. Logue, PhD

Associate Professor, Psychiatry

Mark Logue
857.364.5665
72 E. Concord St Instructional (L)

Biography

My research involves the use of computational tools to search the human genome for genetic variants influencing risk of psychiatric and neurological disorders including panic disorder, post-traumatic stress disorder, and Alzheimer’s disease. The genetics of these traits is complex, as multiple genes interact with environmental factors to determine an individual’s risk. When studying psychiatric traits, this complexity is compounded because psychiatric disorders are not distinct at the genetic level. For example, genetic variants that increase risk of developing panic disorder may also predispose an individual to bipolar disorder or phobias. To unravel this complexity, information must be integrated from a variety of sources, including families with a multiple affected individuals, large case-control study samples, and samples from different ancestral populations. The type of genetic data that can be examined is similarly diverse and can include microsatellite markers, single nucleotide polymorphisms, and base-pair level sequence data. By leveraging these multiple sources of data, and by using analysis methods that allow for this complexity at both the genetic and trait level, the presence of disease can be correlated with variants across multiple genes. The identification of these variants can implicate new biological systems or molecular pathways which are disrupted, potentially resulting in the development of new biomarkers of disease, new treatments, or personalized therapies based on a patient’s genetic profile.

Other Positions

  • Associate Professor, Biostatistics, Boston University School of Public Health
  • Investigator, Framingham Heart Study
  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
  • VA Boston Healthcare System
  • Member, Genome Science Institute, Boston University

Education

  • University of Iowa, PhD
  • University of Iowa, MS
  • University of Oregon, BS

Classes Taught

  • GMSGE701

Publications

  • Published on 3/21/2022

    Hawn SE, Neale Z, Wolf EJ, Zhao X, Pierce M, Fein-Schaffer D, Milberg W, McGlinchey R, Logue M, Miller MW. Methylation of the AIM2 gene: An epigenetic mediator of PTSD-related inflammation and neuropathology plasma biomarkers. Depress Anxiety. 2022 Apr; 39(4):323-333. PMID: 35312143.

    Read at: PubMed
  • Published on 3/15/2022

    Sun D, Rakesh G, Clarke-Rubright EK, Haswell CC, Logue M, O'Leary EN, Cotton AS, Xie H, Dennis EL, Jahanshad N, Salminen LE, Thomopoulos SI, Rashid F, Ching CRK, Koch SBJ, Frijling JL, Nawijn L, van Zuiden M, Zhu X, Suarez-Jimenez B, Sierk A, Walter H, Manthey A, Stevens JS, Fani N, van Rooij SJH, Stein M, Bomyea J, Koerte I, Choi K, van de Werff SJA, Vermeiren RRJM, Herzog J, Lebois LAM, Baker JT, Ressler KJ, Olson EA, Straube T, Korgaonkar MS, Andrew E, Zhu Y, Li G, Ipser J, Hudson A, Peverill M, Sambrook K, Gordon E, Baugh L, Forster G, Simons R, Simons J, Magnotta V, Maron-Katz A, du Plessis S, Disner S, Davenport N, Grupe D, Nitschke J, deRoon-Cassini TA, Fitzgerald J, Krystal JH, Levy I, Olff M, Veltman DJ, Wang L, Neria Y, De Bellis MD, Jovanovic T, Daniels JK, Shenton M, van de Wee NJA, Schmahl C, Kaufman ML, Rosso IM, Sponheim SR, Hofmann DB, Bryant RA, Fercho KA, Stein DJ, Mueller SC, Phan L, McLaughlin KA, Davidson RJ, Larson C, May G, Nelson SM, Abdallah CG, Gomaa H, Etkin A, Seedat S, Harpaz-Rotem I, Liberzon I, Wang X, Thompson PM, Morey RA. Remodeling of the Cortical Structural Connectome in Posttraumatic Stress Disorder: Results from the ENIGMA-PGC PTSD Consortium. Biol Psychiatry Cogn Neurosci Neuroimaging. 2022 Mar 15. PMID: 35307575.

    Read at: PubMed
  • Published on 2/21/2022

    Gustavson DE, Reynolds CA, Hohman TJ, Jefferson AL, Elman JA, Panizzon MS, Neale MC, Logue MW, Lyons MJ, Franz CE, Kremen WS. Alzheimer's Disease Polygenic Scores Predict Changes in Episodic Memory and Executive Function Across 12 Years in Late Middle Age. J Int Neuropsychol Soc. 2022 Feb 21; 1-12. PMID: 35184795.

    Read at: PubMed
  • Published on 1/7/2022

    Katrinli S, Maihofer AX, Wani AH, Pfeiffer JR, Ketema E, Ratanatharathorn A, Baker DG, Boks MP, Geuze E, Kessler RC, Risbrough VB, Rutten BPF, Stein MB, Ursano RJ, Vermetten E, Logue MW, Nievergelt CM, Smith AK, Uddin M. Epigenome-wide meta-analysis of PTSD symptom severity in three military cohorts implicates DNA methylation changes in genes involved in immune system and oxidative stress. Mol Psychiatry. 2022 Jan 07. PMID: 34992238.

    Read at: PubMed
  • Published on 12/16/2021

    Zheng Y, Garrett ME, Sun D, Clarke-Rubright EK, Haswell CC, Maihofer AX, Elman JA, Franz CE, Lyons MJ, Kremen WS, Peverill M, Sambrook K, McLaughlin KA, Davenport ND, Disner S, Sponheim SR, Andrew E, Korgaonkar M, Bryant R, Varkevisser T, Geuze E, Coleman J, Beckham JC, Kimbrel NA, Sullivan D, Miller M, Hayes J, Verfaellie M, Wolf E, Salat D, Spielberg JM, Milberg W, McGlinchey R, Dennis EL, Thompson PM, Medland S, Jahanshad N, Nievergelt CM, Ashley-Koch AE, Logue MW, Morey RA. Trauma and posttraumatic stress disorder modulate polygenic predictors of hippocampal and amygdala volume. Transl Psychiatry. 2021 12 16; 11(1):637. PMID: 34916497.

    Read at: PubMed
  • Published on 12/1/2021

    Hersh SW, You Y, Aslebagh R, Shaffer SA, Ikezu S, Mez J, Lunetta KL, Logue MW, Farrer LA, Ikezu T. Alzheimer's disease associated AKAP9 I2558M mutation alters posttranslational modification and interactome of tau and cellular functions in CRISPR-edited human neuronal cells. Alzheimers Dement. 2021 Dec; 17 Suppl 2:e058592. PMID: 34971140.

    Read at: PubMed
  • Published on 10/14/2021

    Eglit GML, Elman JA, Panizzon MS, Sanderson-Cimino M, Williams ME, Dale AM, Eyler LT, Fennema-Notestine C, Gillespie NA, Gustavson DE, Hatton SN, Hagler DJ, Hauger RL, Jak AJ, Logue MW, McEvoy LK, McKenzie RE, Neale MC, Puckett O, Reynolds CA, Toomey R, Tu XM, Whitsel N, Xian H, Lyons MJ, Franz CE, Kremen WS. Paradoxical cognitive trajectories in men from earlier to later adulthood. Neurobiol Aging. 2022 01; 109:229-238. PMID: 34785406.

    Read at: PubMed
  • Published on 9/28/2021

    Maihofer AX, Choi KW, Coleman JRI, Daskalakis NP, Denckla CA, Ketema E, Morey RA, Polimanti R, Ratanatharathorn A, Torres K, Wingo AP, Zai CC, Aiello AE, Almli LM, Amstadter AB, Andersen SB, Andreassen OA, Arbisi PA, Ashley-Koch AE, Austin SB, Avdibegovic E, Borglum AD, Babic D, Bækvad-Hansen M, Baker DG, Beckham JC, Bierut LJ, Bisson JI, Boks MP, Bolger EA, Bradley B, Brashear M, Breen G, Bryant RA, Bustamante AC, Bybjerg-Grauholm J, Calabrese JR, Caldas-de-Almeida JM, Chen CY, Dale AM, Dalvie S, Deckert J, Delahanty DL, Dennis MF, Disner SG, Domschke K, Duncan LE, Džubur Kulenovic A, Erbes CR, Evans A, Farrer LA, Feeny NC, Flory JD, Forbes D, Franz CE, Galea S, Garrett ME, Gautam A, Gelaye B, Gelernter J, Geuze E, Gillespie CF, Goçi A, Gordon SD, Guffanti G, Hammamieh R, Hauser MA, Heath AC, Hemmings SMJ, Hougaard DM, Jakovljevic M, Jett M, Johnson EO, Jones I, Jovanovic T, Qin XJ, Karstoft KI, Kaufman ML, Kessler RC, Khan A, Kimbrel NA, King AP, Koen N, Kranzler HR, Kremen WS, Lawford BR, Lebois LAM, Lewis C, Liberzon I, Linnstaedt SD, Logue MW, Lori A, Lugonja B, Luykx JJ, Lyons MJ, Maples-Keller JL, Marmar C, Martin NG, Maurer D, Mavissakalian MR, McFarlane A, McGlinchey RE, McLaughlin KA, McLean SA, Mehta D, Mellor R, Michopoulos V, Milberg W, Miller MW, Morris CP, Mors O, Mortensen PB, Nelson EC, Nordentoft M, Norman SB, O'Donnell M, Orcutt HK, Panizzon MS, Peters ES, Peterson AL, Peverill M, Pietrzak RH, Polusny MA, Rice JP, Risbrough VB, Roberts AL, Rothbaum AO, Rothbaum BO, Roy-Byrne P, Ruggiero KJ, Rung A, Rutten BPF, Saccone NL, Sanchez SE, Schijven D, Seedat S, Seligowski AV, Seng JS, Sheerin CM, Silove D, Smith AK, Smoller JW, Sponheim SR, Stein DJ, Stevens JS, Teicher MH, Thompson WK, Trapido E, Uddin M, Ursano RJ, van den Heuvel LL, Van Hooff M, Vermetten E, Vinkers CH, Voisey J, Wang Y, Wang Z, Werge T, Williams MA, Williamson DE, Winternitz S, Wolf C, Wolf EJ, Yehuda R, Young KA, Young RM, Zhao H, Zoellner LA, Haas M, Lasseter H, Provost AC, Salem RM, Sebat J, Shaffer RA, Wu T, Ripke S, Daly MJ, Ressler KJ, Koenen KC, Stein MB, Nievergelt CM. Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information. Biol Psychiatry. 2022 Apr 01; 91(7):626-636. PMID: 34865855.

    Read at: PubMed
  • Published on 9/20/2021

    Logue MW, Zhou Z, Morrison FG, Wolf EJ, Daskalakis NP, Chatzinakos C, Georgiadis F, Labadorf AT, Girgenti MJ, Young KA, Williamson DE, Zhao X, Grenier JG, Huber BR, Miller MW. Gene expression in the dorsolateral and ventromedial prefrontal cortices implicates immune-related gene networks in PTSD. Neurobiol Stress. 2021 Nov; 15:100398. PMID: 34646915.

    Read at: PubMed
  • Published on 7/29/2021

    Wolf EJ, Zhao X, Hawn SE, Morrison FG, Zhou Z, Fein-Schaffer D, Huber B, Miller MW, Logue MW. Gene expression correlates of advanced epigenetic age and psychopathology in postmortem cortical tissue. Neurobiol Stress. 2021 Nov; 15:100371. PMID: 34458511.

    Read at: PubMed

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