Joseph P. Mizgerd, ScD

Professor, Medicine

Joseph Mizgerd
617.358.1186
72 E. Concord St Housman (R)

Biography

Our work focuses on immunology in the lung and its influence on acute lower respiratory tract infections. Our research is illuminating the regulation and function of innate and adaptive immune cells and signals in the lung, and how variations in these parameters determine pneumonia susceptibility and outcome. Lung defense consists of immune resistance (the ability to eliminate microbes) and tissue resilience (the ability to prevent or withstand injurious stimuli from infection and inflammation). Both activities are accomplished by the coordinated activities of diverse cell types within the lung, involving some that are constitutively present (including diverse types of epithelial cells, macrophages, lymphocytes, and more) as well as others newly recruited to the infected tissue (including neutrophils plus additional myeloid or lymphoid cells). Effective and productive communication amongst these cells can efficiently destroy microbes without damaging the lung, maintaining respiratory health. Dysregulation of these pathways instead promotes infection (e.g., pneumonia), injury (e.g., the acute respiratory distress syndrome), and other pulmonary diseases. Elucidating factors that differentiate lung infection resistance and susceptibility will enable new approaches to preventing and treating pneumonia.

Other Positions

  • Director, Pulmonary Center, Boston University Chobanian & Avedisian School of Medicine
  • Professor, Biochemistry & Cell Biology, Boston University Chobanian & Avedisian School of Medicine
  • Professor, Virology, Immunology & Microbiology, Boston University Chobanian & Avedisian School of Medicine
  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
  • Member, Genome Science Institute, Boston University
  • Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Education

  • Harvard School of Public Health, ScD
  • Amherst College, BA

Publications

  • Published on 12/9/2023

    Lee MM, Zuo Y, Steiling K, Mizgerd JP, Kalesan B, Walkey AJ. Clinical risk factors and blood protein biomarkers of 10-year pneumonia risk. medRxiv. 2023 Dec 09. PMID: 38105941.

    Read at: PubMed
  • Published on 9/14/2023

    Lyon De Ana C, Shenoy AT, Barker KA, Arafa EI, Etesami NS, Korkmaz FT, Soucy AM, Breen MP, Martin IMC, Tilton BR, Devarajan P, Crossland NA, Pihl RMF, Goltry WN, Belkina AC, Jones MR, Quinton LJ, Mizgerd JP. GL7 ligand expression defines a novel subset of CD4+ TRM cells in lungs recovered from pneumococcus. Mucosal Immunol. 2023 Oct; 16(5):699-710. PMID: 37604254.

    Read at: PubMed
  • Published on 9/14/2023

    Banerji R, Grifno GN, Shi L, Smolen D, LeBourdais R, Muhvich J, Eberman C, Hiller BE, Lee J, Regan K, Zheng S, Zhang S, Jiang J, Raslan AA, Breda JC, Pihl R, Traber K, Mazzilli S, Ligresti G, Mizgerd JP, Suki B, Nia HT. Crystal ribcage: a platform for probing real-time lung function at cellular resolution. Nat Methods. 2023 Nov; 20(11):1790-1801. PMID: 37710017.

    Read at: PubMed
  • Published on 8/1/2023

    Aihara F, Wang Y, Belkina AC, Fearns R, Mizgerd JP, Feng F, Kepler TB. Diversity of B Cell Populations and Ig Repertoire in Human Lungs. J Immunol. 2023 Aug 01; 211(3):486-496. PMID: 37314411.

    Read at: PubMed
  • Published on 5/1/2023

    Center DM, Mizgerd JP. In Memoriam: Jerome S. Brody, M.D., A Red Journal Founder. Am J Respir Cell Mol Biol. 2023 May; 68(5):465-466. PMID: 36780672.

    Read at: PubMed
  • Published on 12/8/2022

    Korkmaz FT, Shenoy AT, Symer EM, Baird LA, Odom CV, Arafa EI, Dimbo EL, Na E, Molina-Arocho W, Brudner M, Standiford TJ, Mehta JL, Sawamura T, Jones MR, Mizgerd JP, Traber KE, Quinton LJ. Lectin-like oxidized low-density lipoprotein receptor 1 attenuates pneumonia-induced lung injury. JCI Insight. 2022 Dec 08; 7(23). PMID: 36264633.

    Read at: PubMed
  • Published on 8/16/2022

    Serrano GE, Walker JE, Tremblay C, Piras IS, Huentelman MJ, Belden CM, Goldfarb D, Shprecher D, Atri A, Adler CH, Shill HA, Driver-Dunckley E, Mehta SH, Caselli R, Woodruff BK, Haarer CF, Ruhlen T, Torres M, Nguyen S, Schmitt D, Rapscak SZ, Bime C, Peters JL, Alevritis E, Arce RA, Glass MJ, Vargas D, Sue LI, Intorcia AJ, Nelson CM, Oliver J, Russell A, Suszczewicz KE, Borja CI, Cline MP, Hemmingsen SJ, Qiji S, Hobgood HM, Mizgerd JP, Sahoo MK, Zhang H, Solis D, Montine TJ, Berry GJ, Reiman EM, Röltgen K, Boyd SD, Pinsky BA, Zehnder JL, Talbot P, Desforges M, DeTure M, Dickson DW, Beach TG. SARS-CoV-2 Brain Regional Detection, Histopathology, Gene Expression, and Immunomodulatory Changes in Decedents with COVID-19. J Neuropathol Exp Neurol. 2022 Aug 16; 81(9):666-695. PMID: 35818336.

    Read at: PubMed
  • Published on 3/8/2022

    Arafa EI, Shenoy AT, Barker KA, Etesami NS, Martin IM, Lyon De Ana C, Na E, Odom CV, Goltry WN, Korkmaz FT, Wooten AK, Belkina AC, Guillon A, Forsberg EC, Jones MR, Quinton LJ, Mizgerd JP. Recruitment and training of alveolar macrophages after pneumococcal pneumonia. JCI Insight. 2022 Mar 08; 7(5). PMID: 35133985.

    Read at: PubMed
  • Published on 2/9/2022

    Na E, Allen E, Baird LA, Odom CV, Korkmaz FT, Shenoy AT, Matschulat AM, Jones MR, Kotton DN, Mizgerd JP, Varelas X, Traber KE, Quinton LJ. Epithelial LIF signaling limits apoptosis and lung injury during bacterial pneumonia. Am J Physiol Lung Cell Mol Physiol. 2022 Apr 01; 322(4):L550-L563. PMID: 35137631.

    Read at: PubMed
  • Published on 2/7/2022

    Sanders NL, Martin IMC, Sharma A, Jones MR, Quinton LJ, Bosmann M, Mizgerd JP. Neutrophil Extracellular Traps as an Exacerbating Factor in Bacterial Pneumonia. Infect Immun. 2022 03 17; 90(3):e0049121. PMID: 35130455.

    Read at: PubMed

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