Our work focuses on immunology in the lung and its influence on acute lower respiratory tract infections. Our research is illuminating the regulation and function of innate and adaptive immune cells and signals in the lung, and how variations in these parameters determine pneumonia susceptibility and outcome. Lung defense consists of immune resistance (the ability to eliminate microbes) and tissue resilience (the ability to prevent or withstand injurious stimuli from infection and inflammation). Both activities are accomplished by the coordinated activities of diverse cell types within the lung, involving some that are constitutively present (including diverse types of epithelial cells, macrophages, lymphocytes, and more) as well as others newly recruited to the infected tissue (including neutrophils plus additional myeloid or lymphoid cells). Effective and productive communication amongst these cells can efficiently destroy microbes without damaging the lung, maintaining respiratory health. Dysregulation of these pathways instead promotes infection (e.g., pneumonia), injury (e.g., the acute respiratory distress syndrome), and other pulmonary diseases. Elucidating factors that differentiate lung infection resistance and susceptibility will enable new approaches to preventing and treating pneumonia.
- Professor, Microbiology, Boston University School of Medicine
- Professor, Pulmonary, Allergy, Sleep & Critical Care Medicine, Medicine, Boston University School of Medicine
- Director, Pulmonary Center, Boston University School of Medicine
- Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
- Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences
- Member, Genome Science Institute, Boston University
- Harvard School of Public Health, ScD
- Amherst College, BA
- Published on 9/30/2020
Sagar M, Reifler K, Rossi M, Miller NS, Sinha P, White L, Mizgerd JP. Recent endemic coronavirus infection is associated with less severe COVID-19. J Clin Invest. 2020 Sep 30. PMID: 32997649.
- Published on 3/31/2020
Wooten AK, Shenoy AT, Arafa EI, Akiyama H, Martin IMC, Jones MR, Quinton LJ, Gummuluru S, Bai G, Mizgerd JP. Unique Roles for Streptococcus pneumoniae Phosphodiesterase 2 in Cyclic di-AMP Catabolism and Macrophage Responses. Front Immunol. 2020; 11:554. PMID: 32300347.
- Published on 3/9/2020
Semler MW, Bernard GR, Aaron SD, Angus DC, Biros MH, Brower RG, Calfee CS, Colantuoni EA, Ferguson ND, Gong MN, Hopkins RO, Hough CL, Iwashyna TJ, Levy BD, Martin TR, Matthay MA, Mizgerd JP, Moss M, Needham DM, Self WH, Seymour CW, Stapleton RD, Thompson BT, Wunderink RG, Aggarwal NR, Reineck LA. Identifying Clinical Research Priorities in Adult Pulmonary and Critical Care: NHLBI Working Group Report. Am J Respir Crit Care Med. 2020 Mar 09. PMID: 32150460.
- Published on 2/27/2020
Guillon A, Arafa EI, Barker KA, Belkina AC, Martin I, Shenoy AT, Wooten AK, Lyon De Ana C, Dai A, Labadorf A, Hernandez Escalante J, Dooms H, Blasco H, Traber KE, Jones MR, Quinton LJ, Mizgerd JP. Pneumonia recovery reprograms the alveolar macrophage pool. JCI Insight. 2020 02 27; 5(4). PMID: 31990682.
- Published on 1/2/2020
Lin WC, Gowdy KM, Madenspacher JH, Zemans RL, Yamamoto K, Lyons-Cohen M, Nakano H, Janardhan K, Williams CJ, Cook DN, Mizgerd JP, Fessler MB. Epithelial membrane protein 2 governs transepithelial migration of neutrophils into the airspace. J Clin Invest. 2020 01 02; 130(1):157-170. PMID: 31550239.
- Published on 11/20/2019
Shenoy AT, Wasserman GA, Arafa EI, Wooten AK, Smith NMS, Martin IMC, Jones MR, Quinton LJ, Mizgerd JP. Lung CD4+ resident memory T cells remodel epithelial responses to accelerate neutrophil recruitment during pneumonia. Mucosal Immunol. 2020 03; 13(2):334-343. PMID: 31748706.
- Published on 8/15/2019
Traber KE, Dimbo EL, Symer EM, Korkmaz FT, Jones MR, Mizgerd JP, Quinton LJ. Roles of interleukin-11 during acute bacterial pneumonia. PLoS One. 2019; 14(8):e0221029. PMID: 31415618.
- Published on 7/23/2019
Kim Y, Allen E, Baird LA, Symer EM, Korkmaz FT, Na E, Odom CV, Jones MR, Mizgerd JP, Traber KE, Quinton LJ. NF-?B RelA Is Required for Hepatoprotection during Pneumonia and Sepsis. Infect Immun. 2019 08; 87(8). PMID: 31160364.
- Published on 12/1/2018
Mizgerd JP. Inflammation and Pneumonia: Why Are Some More Susceptible than Others? Clin Chest Med. 2018 12; 39(4):669-676. PMID: 30390740.
- Published on 7/15/2018
Dela Cruz CS, Wunderink RG, Christiani DC, Cormier SA, Crothers K, Doerschuk CM, Evans SE, Goldstein DR, Khatri P, Kobzik L, Kolls JK, Levy BD, Metersky ML, Niederman MS, Nusrat R, Orihuela CJ, Peyrani P, Prince AS, Ramírez JA, Ridge KM, Sethi S, Suratt BT, Sznajder JI, Tsalik EL, Walkey AJ, Yende S, Aggarwal NR, Caler EV, Mizgerd JP. Future Research Directions in Pneumonia. NHLBI Working Group Report. Am J Respir Crit Care Med. 2018 07 15; 198(2):256-263. PMID: 29546996.
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