Jean-Pierre Roussarie
Assistant Professor, Anatomy & Neurobiology
Biography
The lab is interested in deciphering the molecular events leading to neurodegeneration in Alzheimer’s disease. Like most neurodegenerative diseases, Alzheimer’s affects only very specific sets of neurons in its earliest stages. These neurons are located in the entorhinal cortex, a brain region indispensable for new memory formation. We think that understanding the particularities of these entorhinal cortex neurons will yield novel insights into the Alzheimer’s pathological processes. Eventually this will lead to the identification of new therapeutic targets to prevent neurodegeneration. In order to elucidate the properties of entorhinal neurons at single-cell resolution, we use a combination of mouse models, human postmortem tissue, novel in vitro culture protocols, and in silico modeling.
Websites
Publications
- Published on 2/18/2022
Montalban E, Giralt A, Taing L, Schut EHS, Supiot LF, Castell L, Nakamura Y, de Pins B, Pelosi A, Goutebroze L, Tuduri P, Wang W, Neiburga KD, Vestito L, Castel J, Luquet S, Nairn AC, Hervé D, Heintz N, Martin C, Greengard P, Valjent E, Meye FJ, Gambardella N, Roussarie JP, Girault JA. Translational profiling of mouse dopaminoceptive neurons reveals region-specific gene expression, exon usage, and striatal prostaglandin E2 modulatory effects. Mol Psychiatry. 2022 Apr; 27(4):2068-2079. PMID: 35177825.
Read at: PubMed - Published on 10/19/2020
Roussarie JP, Rodriguez-Rodriguez P. Deciphering cell-type specific signal transduction in the brain: Challenges and promises. Adv Pharmacol. 2021; 90:145-171. PMID: 33706931.
Read at: PubMed - Published on 6/29/2020
Roussarie JP, Yao V, Rodriguez-Rodriguez P, Oughtred R, Rust J, Plautz Z, Kasturia S, Albornoz C, Wang W, Schmidt EF, Dannenfelser R, Tadych A, Brichta L, Barnea-Cramer A, Heintz N, Hof PR, Heiman M, Dolinski K, Flajolet M, Troyanskaya OG, Greengard P. Selective Neuronal Vulnerability in Alzheimer's Disease: A Network-Based Analysis. Neuron. 2020 09 09; 107(5):821-835.e12. PMID: 32603655.
Read at: PubMed - Published on 7/27/2015
Brichta L, Shin W, Jackson-Lewis V, Blesa J, Yap EL, Walker Z, Zhang J, Roussarie JP, Alvarez MJ, Califano A, Przedborski S, Greengard P. Identification of neurodegenerative factors using translatome-regulatory network analysis. Nat Neurosci. 2015 Sep; 18(9):1325-33. PMID: 26214373.
Read at: PubMed - Published on 1/1/2015
Vidalain PO, Jacob Y, Hagemeijer MC, Jones LM, Neveu G, Roussarie JP, Rottier PJ, Tangy F, de Haan CA. A field-proven yeast two-hybrid protocol used to identify coronavirus-host protein-protein interactions. Methods Mol Biol. 2015; 1282:213-29. PMID: 25720483.
Read at: PubMed - Published on 9/25/2009
Brahic M, Roussarie JP. Axon-myelin interactions during a viral infection of the central nervous system. PLoS Pathog. 2009 Sep; 5(9):e1000519. PMID: 19779566.
Read at: PubMed - Published on 12/26/2007
Roussarie JP, Ruffié C, Edgar JM, Griffiths I, Brahic M. Axon myelin transfer of a non-enveloped virus. PLoS One. 2007 Dec 26; 2(12):e1331. PMID: 18159229.
Read at: PubMed - Published on 2/1/2007
Roussarie JP, Ruffié C, Brahic M. The role of myelin in Theiler's virus persistence in the central nervous system. PLoS Pathog. 2007 Feb; 3(2):e23. PMID: 17305428.
Read at: PubMed - Published on 12/1/2004
Mena I, Roussarie JP, Brahic M. Infection of macrophage primary cultures by persistent and nonpersistent strains of Theiler's virus: role of capsid and noncapsid viral determinants. J Virol. 2004 Dec; 78(23):13356-61. PMID: 15542687.
Read at: PubMed