Jean-Pierre Roussarie

Assistant Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

The lab is interested in deciphering the molecular events leading to neurodegeneration in Alzheimer’s disease. Like most neurodegenerative diseases, Alzheimer’s affects only very specific sets of neurons in its earliest stages. These neurons are located in the entorhinal cortex, a brain region indispensable for new memory formation. We think that understanding the particularities of these entorhinal cortex neurons will yield novel insights into the Alzheimer’s pathological processes. Eventually this will lead to the identification of new therapeutic targets to prevent neurodegeneration. In order to elucidate the properties of entorhinal neurons at single-cell resolution, we use a combination of mouse models, human postmortem tissue, novel in vitro culture protocols, and in silico modeling.

Publications

  • Published 1/29/2025

    Rodriguez-Rodriguez P, Wang W, Tsagkogianni C, Feng I, Morello-Megias A, Jain K, Alanko V, Kahvecioglu HA, Mohammadi E, Li X, Flajolet M, Sandebring-Matton A, Maioli S, Vidal N, Milosevic A, Roussarie JP. Cell-type specific profiling of human entorhinal cortex at the onset of Alzheimer's disease neuropathology. bioRxiv. 2025 Jan 29. PMID: 39803521.

    Read at: PubMed

  • Published 12/30/2024

    Zhang R, Rodriguez-Rodriguez P, Medrihan L, Chang JC, Ferraro T, Del Cioppo Vasques P, Wang W, Menard C, Cathomas F, Chan KL, Parise L, Shaham S, Roussarie JP, Troyanskaya O, Russo SJ, Milosevic A. Astrocyte-derived extracellular matrix proteins regulate synapse remodeling in stress-induced depression. bioRxiv. 2024 Dec 30. PMID: 39803419.

    Read at: PubMed

  • Published 7/5/2024

    Rodriguez-Rodriguez P, Arroyo-Garcia LE, Tsagkogianni C, Li L, Wang W, Végvári Á, Salas-Allende I, Plautz Z, Cedazo-Minguez A, Sinha SC, Troyanskaya O, Flajolet M, Yao V, Roussarie JP. A cell autonomous regulator of neuronal excitability modulates tau in Alzheimer's disease vulnerable neurons. Brain. 2024 Jul 05; 147(7):2384-2399. PMID: 38462574.

    Read at: PubMed

  • Published 5/7/2024

    Lai Q, Dannenfelser R, Roussarie JP, Yao V. Disentangling associations between complex traits and cell types with seismic. bioRxiv. 2024 May 07. PMID: 38765980.

    Read at: PubMed

  • Published 8/12/2023

    Montalban E, Giralt A, Taing L, Nakamura Y, Pelosi A, Brown M, de Pins B, Valjent E, Martin M, Nairn AC, Greengard P, Flajolet M, Hervé D, Gambardella N, Roussarie JP, Girault JA. Operant Training for Highly Palatable Food Alters Translating Messenger RNA in Nucleus Accumbens D2 Neurons and Reveals a Modulatory Role of Ncdn. Biol Psychiatry. 2024 May 15; 95(10):926-937. PMID: 37579933.

    Read at: PubMed

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