Jayandra J. Himali, PhD

Adjunct Associate Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Jayandra Jung Himali, PhD, serves as an adjunct Associate Professor of Neurology and Biostatistics at Boston University Schools of Medicine and of Public Health, and a Center Faculty Member of the Framingham Heart Study (FHS). He has been engaged in collaborative public health research and teaching for over a decade. As a senior Biostatistician at the Neurology core of FHS, his research efforts are focused on the interrelated areas of: (1) the epidemiology of dementia and Alzheimer’s disease (AD) and relating traditional and novel biomarkers to the risk of dementia and AD; (2) the epidemiology of stroke and vascular cognitive impairment; (3) understanding vascular contributions to cognitive impairment and dementia including AD; and (4) investigating the role of modifiable lifestyle factors: sleep, diet and physical activity on the incidence of dementia, cognitive decline and MRI-defined brain aging. His research is also focused on outcome assessment in Epilepsy, Parkinson’s disease, and neuropathology. He has received the Nepal Bidhya Bhusan Class ‘A’ Medal from the government of Nepal for highest academic achievement in doctoral studies.

Publications

  • Published 9/9/2025

    Yiallourou S, Baril AA, Wiedner C, Misialek JR, Kline CE, Harrison S, Cannon E, Yang Q, Bernal R, Bisson A, Himali D, Cavuoto M, Weihs A, Beiser A, Gottesman RF, Leng Y, Lopez O, Lutsey PL, Purcell SM, Redline S, Seshadri S, Stone KL, Yaffe K, Ancoli-Israel S, Xiao Q, Vaou EO, Himali JJ, Pase MP. Sleep architecture and dementia risk in adults: an analysis of 5 cohorts from the Sleep and Dementia Consortium. Sleep. 2025 Sep 09; 48(9). PMID: 40377976.

    Read at: PubMed

  • Published 8/21/2025

    Araujo-Contreras R, Pinheiro AA, Ekenze O, Sisto J, Aparicio HJ, Beiser A, Himali JJ, Lioutas V, DeCarli C, Seshadri S, Demissie S, Romero JR. Multi-marker cerebral small vessel disease score and risk of incident depression: The Framingham Heart Study. J Affect Disord. 2025 Aug 21; 392:120089. PMID: 40848767.

    Read at: PubMed

  • Published 8/7/2025

    Duan D, Jun JC, Johnson DA, Ahima RS, Himali JJ, Bertoni AG, Redline S, Echouffo-Tcheugui JB. Associations of Sleep Health and Metabolic Syndrome Severity in Black Individuals: The Jackson Heart Sleep Study. J Clin Endocrinol Metab. 2025 Aug 07; 110(9):e2864-e2870. PMID: 40339134.

    Read at: PubMed

  • Published 8/5/2025

    Chakkarai S, Sadowski M, Yang Q, Ray A, Wang R, Thomas LF, Fuentes RP, Tabar MS, Cui B, Jian X, Nyquist PA, Gill D, Aiello AE, Montine TJ, Bukhari S, Rogalski E, Edland SE, Haan ME, Kawas CH, Corrada MM, Salardini A, Chen ZZ, Himali JJ, Satizabal CL, Gerszten RE, Åsvold BO, Fornage M, Cruchaga C, Habes M, Chasman DI, Launer LJ, Flanagan ME, Brumpton BM, Georgakis MK, Zaitlen N, Ruiz A, Debette S, Seshadri S, Sargurupremraj M. Cross-tissue omics-guided drug repurposing triangulates novel targetable mechanisms for Alzheimer's disease and candidate genetic biomarkers for treatment stratification. Res Sq. 2025 Aug 05. PMID: 40799764.

    Read at: PubMed

  • Published 7/31/2025

    Wadop YN, Bernal R, Njamnshi WY, Satizabal CL, Beiser A, Ruiz A, Njamnshi AK, Vasan RS, Seshadri S, Himali JJ, Fongang B. Altered Gut Microbiota Mediates the Association between APOE Genotype and Amyloid-ß Accumulation in Middle-Aged Adults. bioRxiv. 2025 Jul 31. PMID: 40766561.

    Read at: PubMed

View All 153 Publications:   View Full Profile in BUMC

Other Positions

  • Investigator
    Framingham Heart Study

Websites

Education

  • Boston University School of Public Health, PhD
  • Tribhuvan University, MSc
  • Tribhuvan University, BSc

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