James E. Galagan, PhD

Professor, Biomedical Engineering

James Galagan
617.358.0695
24 Cummington St

Biography

Dr. Galagan’s research is focused on Systems Biology of microbial organisms, specficially Mycobacterium tuberculosis – the causative agent of tuberculosis – and the fungus Neurospora crassa. The Galagan Lab is an interdisciplinary group that combines computational biology, genomics, and experimental lab work. Specific interests and projects include:

• Using a genomics, computational modeling, and experimental systems-identification techniques to reconstruct the gene regulatory network of M. tuberculosis.
• Developing and experimentally validating computational models of microbial metabolism for M. tuberculosis and N. crassa.
• Using high-throughput sequencing and comparative sequence analysis to study the functional evolution of M. tuberculosis.
• Developing computational methods for genomic data analysis (including gene prediction, gene expression analysis, and polymorphism discovery)
• Developing experimental methods for microbial systems identification and analysis, drawing on electrical and mechanical systems identification methods

Other Positions

  • Associate Professor, Microbiology, Boston University School of Medicine
  • Faculty, National Emerging Infectious Disease Lab, Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
  • Associate Director of Systems Biology, National Emerging Infectious Disease Lab, Boston University School of Medicine
  • Associate Director of Microbial Genome Analysis, Broad Institute
  • Member, Genome Science Institute, Boston University

Education

  • Massachusetts Institute of Technology, PhD
  • University of California, Davis, BS

Publications

  • Published on 5/4/2022

    Grazon C, Chern M, Lally P, Baer RC, Fan A, Lecommandoux S, Klapperich C, Dennis AM, Galagan JE, Grinstaff MW. The quantum dot vs. organic dye conundrum for ratiometric FRET-based biosensors: which one would you chose? Chem Sci. 2022 Jun 07; 13(22):6715-6731. PMID: 35756504.

    Read at: PubMed
  • Published on 5/1/2022

    Tierrafría VH, Rioualen C, Salgado H, Lara P, Gama-Castro S, Lally P, Gómez-Romero L, Peña-Loredo P, López-Almazo AG, Alarcón-Carranza G, Betancourt-Figueroa F, Alquicira-Hernández S, Polanco-Morelos JE, García-Sotelo J, Gaytan-Nuñez E, Méndez-Cruz CF, Muñiz LJ, Bonavides-Martínez C, Moreno-Hagelsieb G, Galagan JE, Wade JT, Collado-Vides J. RegulonDB 11.0: Comprehensive high-throughput datasets on transcriptional regulation in Escherichia coli K-12. Microb Genom. 2022 May; 8(5). PMID: 35584008.

    Read at: PubMed
  • Published on 4/12/2022

    Sankar K, Baer R, Grazon C, Sabatelle RC, Lecommandoux S, Klapperich CM, Galagan JE, Grinstaff MW. An Allosteric Transcription Factor DNA-Binding Electrochemical Biosensor for Progesterone. ACS Sens. 2022 Apr 22; 7(4):1132-1137. PMID: 35412319.

    Read at: PubMed
  • Published on 2/7/2022

    Zamani M, Dupaty J, Baer RC, Kuzmanovic U, Fan A, Grinstaff MW, Galagan JE, Klapperich CM. Paper-Based Progesterone Sensor Using an Allosteric Transcription Factor. ACS Omega. 2022 Feb 22; 7(7):5804-5808. PMID: 35224340.

    Read at: PubMed
  • Published on 1/19/2021

    Kolluri N, Kamath S, Lally P, Zanna M, Galagan J, Gitaka J, Kamita M, Cabodi M, Lolabattu SR, Klapperich CM. Development and Clinical Validation of Iso-IMRS: A Novel Diagnostic Assay for P. falciparum Malaria. Anal Chem. 2021 02 02; 93(4):2097-2105. PMID: 33464825.

    Read at: PubMed
  • Published on 9/18/2020

    Chern M, Garden PM, Baer RC, Galagan JE, Dennis AM. Transcription Factor Based Small-Molecule Sensing with a Rapid Cell Phone Enabled Fluorescent Bead Assay. Angew Chem Int Ed Engl. 2020 11 23; 59(48):21597-21602. PMID: 32945589.

    Read at: PubMed
  • Published on 9/18/2020

    Chen M, Grazon C, Sensharma P, Nguyen TT, Feng Y, Chern M, Baer RC, Varongchayakul N, Cook K, Lecommandoux S, Klapperich CM, Galagan JE, Dennis AM, Grinstaff MW. Hydrogel-Embedded Quantum Dot-Transcription Factor Sensors for Quantitative Progesterone Detection. ACS Appl Mater Interfaces. 2020 Sep 30; 12(39):43513-43521. PMID: 32893612.

    Read at: PubMed
  • Published on 7/21/2020

    Chen M, Nguyen TT, Varongchayakul N, Grazon C, Chern M, Baer RC, Lecommandoux S, Klapperich CM, Galagan JE, Dennis AM, Grinstaff MW. Surface Immobilized Nucleic Acid-Transcription Factor Quantum Dots for Biosensing. Adv Healthc Mater. 2020 09; 9(17):e2000403. PMID: 32691962.

    Read at: PubMed
  • Published on 7/14/2020

    Mejía-Almonte C, Busby SJW, Wade JT, van Helden J, Arkin AP, Stormo GD, Eilbeck K, Palsson BO, Galagan JE, Collado-Vides J. Redefining fundamental concepts of transcription initiation in bacteria. Nat Rev Genet. 2020 11; 21(11):699-714. PMID: 32665585.

    Read at: PubMed
  • Published on 6/9/2020

    Wu X, Cao B, Aquino P, Chiu TP, Chen C, Jiang S, Deng Z, Chen S, Rohs R, Wang L, Galagan JE, Dedon PC. Epigenetic competition reveals density-dependent regulation and target site plasticity of phosphorothioate epigenetics in bacteria. Proc Natl Acad Sci U S A. 2020 06 23; 117(25):14322-14330. PMID: 32518115.

    Read at: PubMed

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