Irving J. Bigio, PhD

Professor, Medicine

Irving Bigio
44 Cummington St


Dr. Irving Bigio has been a professor of Biomedical Engineering, and Electrical & Computer Engineering, at Boston University for the past 22 years. His is primarily interested in using biomedical optics to develop clinical and research applications of optical technologies. His lab was founded in 2001 and focuses on clinical diagnostics based on elastic scattering spectroscopy, on laboratory applications to monitor sub-cellular dynamics in vitro, and novel methods to image neuronal activation patterns in label-free neural tissues. He has mentored numerous graduate and undergraduate students and in 2010 he received a Distinguished Lecturer Award from the Boston University College of Engineering.

Other Positions

  • Professor, Biomedical Engineering, Boston University School of Engineering
  • Member, BU-BMC Cancer Center, Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University


  • University of Michigan at Ann Arbor, PhD
  • University of Michigan at Ann Arbor, PhD
  • University of Michigan at Ann Arbor, MS
  • University of Michigan at Ann Arbor, BS


  • Published on 3/12/2020

    Raufer S, Idoff C, Zosuls A, Marino G, Blanke N, Bigio IJ, O'Malley JT, Burgess BJ, Nadol JB, Guinan JJ, Nakajima HH. Anatomy of the Human Osseous Spiral Lamina and Cochlear Partition Bridge: Relevance for Cochlear Partition Motion. J Assoc Res Otolaryngol. 2020 Mar 12. PMID: 32166603.

    Read at: PubMed
  • Published on 8/24/2019

    Rodriguez-Diaz E, Manolakos D, Christman H, Bonning MA, Geisse JK, A'Amar OM, Leffell DJ, Bigio IJ. Optical Spectroscopy as a Method for Skin Cancer Risk Assessment. Photochem Photobiol. 2019 11; 95(6):1441-1445. PMID: 31287160.

    Read at: PubMed
  • Published on 5/9/2019

    Belghasem ME, A'amar O, Roth D, Walker J, Arinze N, Richards SM, Francis JM, Salant DJ, Chitalia VC, Bigio IJ. Towards minimally-invasive, quantitative assessment of chronic kidney disease using optical spectroscopy. Sci Rep. 2019 05 09; 9(1):7168. PMID: 31073168.

    Read at: PubMed
  • Published on 4/10/2019

    Sharaha U, Rodriguez-Diaz E, Sagi O, Riesenberg K, Salman A, Bigio IJ, Huleihel M. Fast and reliable determination of Escherichia coli susceptibility to antibiotics: Infrared microscopy in tandem with machine learning algorithms. J Biophotonics. 2019 07; 12(7):e201800478. PMID: 30916881.

    Read at: PubMed
  • Published on 1/25/2019

    Sharaha U, Rodriguez-Diaz E, Sagi O, Riesenberg K, Lapidot I, Segal Y, Bigio IJ, Huleihel M, Salman A. Detection of Extended-Spectrum ß-Lactamase-Producing Escherichia coli Using Infrared Microscopy and Machine-Learning Algorithms. Anal Chem. 2019 02 05; 91(3):2525-2530. PMID: 30681832.

    Read at: PubMed
  • Published on 8/1/2018

    Zhu Y, Fearn T, Chicken DW, Austwick MR, Somasundaram SK, Mosse CA, Clark B, Bigio IJ, Keshtgar MRS, Bown SG. Elastic scattering spectroscopy for early detection of breast cancer: partially supervised Bayesian image classification of scanned sentinel lymph nodes. J Biomed Opt. 2018 08; 23(8):1-9. PMID: 30132305.

    Read at: PubMed
  • Published on 8/11/2017

    Sharaha U, Rodriguez-Diaz E, Riesenberg K, Bigio IJ, Huleihel M, Salman A. Using Infrared Spectroscopy and Multivariate Analysis to Detect Antibiotics' Resistant Escherichia coli Bacteria. Anal Chem. 2017 09 05; 89(17):8782-8790. PMID: 28731324.

    Read at: PubMed
  • Published on 7/28/2017

    Grillone GA, Wang Z, Krisciunas GP, Tsai AC, Kannabiran VR, Pistey RW, Zhao Q, Rodriguez-Diaz E, A'Amar OM, Bigio IJ. The color of cancer: Margin guidance for oral cancer resection using elastic scattering spectroscopy. Laryngoscope. 2017 Sep; 127 Suppl 4:S1-S9. PMID: 28752518.

    Read at: PubMed
  • Published on 6/12/2017

    Salman A, Sharaha U, Rodriguez-Diaz E, Shufan E, Riesenberg K, Bigio IJ, Huleihel M. Detection of antibiotic resistant Escherichia Coli bacteria using infrared microscopy and advanced multivariate analysis. Analyst. 2017 Jun 12; 142(12):2136-2144. PMID: 28518194.

    Read at: PubMed
  • Published on 4/18/2017

    Nguyen J, Hossain SS, Cooke JRN, Ellis JA, Deci MB, Emala CW, Bruce JN, Bigio IJ, Straubinger RM, Joshi S. Flow arrest intra-arterial delivery of small TAT-decorated and neutral micelles to gliomas. J Neurooncol. 2017 May; 133(1):77-85. PMID: 28421460.

    Read at: PubMed

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