Hugo Javier Aparicio, MD, MPH
Associate Professor, Neurology
Biography
Dr. Aparicio’s research interests include the identification of lifestyle risk factors, biomarkers, neuroimaging markers and genetic influences associated with cerebrovascular diseases. He is particularly interested in the contributions of vascular risk factors to stroke, brain injury and aging, cognitive dysfunction and the development of Alzheimer’s disease and the influence of social determinants of health on these outcomes.
Other Positions
- Investigator, Framingham Heart Study
Education
- University of Pennsylvania School of Medicine, MD
- Harvard School of Public Health, MPH
- Emory University, BA
Publications
- Published on 3/10/2025
Levine DA, Whitney RT, Ye W, Briceño EM, Gross AL, Giordani BJ, Sussman JB, Lazar RM, Howard VJ, Aparicio HJ, Beiser AS, Elkind MSV, Gottesman RF, Koton S, Pendlebury ST, Kollipara AS, Springer MV, Seshadri S, Romero JR, Fitzpatrick AL, Longstreth WT, Hayward RA. Associations Between Stroke Type, Ischemic Stroke Subtypes, and Poststroke Cognitive Trajectories. Stroke. 2025 Apr; 56(4):898-907. PMID: 40062407.
Read at: PubMed - Published on 12/11/2024
Greenberg SM, Aparicio HJ, Furie KL, Goyal MS, Hinman JD, Kozberg M, Leonard A, Fisher MJ. Vascular Neurology Considerations for Antiamyloid Immunotherapy: A Science Advisory From the American Heart Association. Stroke. 2025 Jan; 56(1):e30-e38. PMID: 39660440.
Read at: PubMed - Published on 12/6/2024
van Lent DM, Mesa HG, Short MI, Gonzales MM, Aparicio HJ, Salinas J, Yuan C, Jacques PF, Beiser A, Seshadri S, Jacob ME, Himali JJ. Association between dietary inflammatory index score and incident dementia. Alzheimers Dement. 2025 Jan; 21(1):e14390. PMID: 39641390.
Read at: PubMed - Published on 11/15/2024
Pinheiro A, Aparicio H, Lioutas V, Beiser A, Ekenze O, DeCarli C, Seshadri S, Demissie S, Romero JR. Higher burden of cerebral small vessel disease is associated with risk of incident stroke in community dwelling individuals. medRxiv. 2024 Nov 15. PMID: 39606408.
Read at: PubMed - Published on 11/14/2024
Yau WW, Scott MR, Petrea RE, Buckley RF, Kojis D, Sperling RA, Chhatwal JP, Maillard P, Aparicio HJ, Romero JR, DeCarli CS, Beiser AS, Seshadri S. Sex-Specific Vulnerabilities to Subclinical Vascular Brain Injury in Early Late-Life: The Framingham Heart Study. Ann Neurol. 2025 Mar; 97(3):460-469. PMID: 39540324.
Read at: PubMed - Published on 10/30/2024
Kelly DM, Pinheiro AA, Koini M, Anderson CD, Aparicio H, Hofer E, Kern D, Blacker D, DeCarli C, Hwang SJ, Viswanathan A, Gonzales MM, Beiser AS, Seshadri S, Schmidt R, Demissie S, Romero JR. Impaired kidney function, cerebral small vessel disease and cognitive disorders: the Framingham Heart Study. Nephrol Dial Transplant. 2024 Oct 30; 39(11):1911-1922. PMID: 38565317.
Read at: PubMed - Published on 10/12/2024
Springer MV, Chen B, Whitney RT, Briceño EM, Gross AL, Aparicio HJ, Beiser AS, Burke JF, Giordani B, Gottesman RF, Hayward RA, Howard VJ, Koton S, Lazar RM, Sussman JB, Ye W, Levine DA. Age differences in the change in cognition after stroke. J Stroke Cerebrovasc Dis. 2024 Dec; 33(12):108087. PMID: 39401577.
Read at: PubMed - Published on 7/22/2024
Elmore AR, Adhikari N, Hartley AE, Aparicio HJ, Posner DC, Hemani G, Tilling K, Gaunt TR, Wilson PWF, Casas JP, Gaziano JM, Davey Smith G, Paternoster L, Cho K, Peloso GM. Protein Identification for Stroke Progression via Mendelian Randomization in Million Veteran Program and UK Biobank. Stroke. 2024 Aug; 55(8):2045-2054. PMID: 39038097.
Read at: PubMed - Published on 6/20/2024
Stefanucci L, Moslemi C, Tomé AR, Virtue S, Bidault G, Gleadall NS, Watson LPE, Kwa JE, Burden F, Farrow S, Chen J, Võsa U, Burling K, Walker L, Ord J, Barker P, Warner J, Frary A, Renhstrom K, Ashford SE, Piper J, Biggs G, Erber WN, Hoffman GJ, Schoenmakers N, Erikstrup C, Rieneck K, Dziegiel MH, Ullum H, Azzu V, Vacca M, Aparicio HJ, Hui Q, Cho K, Sun YV, Wilson PW, Bayraktar OA, Vidal-Puig A, Ostrowski SR, Astle WJ, Olsson ML, Storry JR, Pedersen OB, Ouwehand WH, Chatterjee K, Vuckovic D, Frontini M. SMIM1 absence is associated with reduced energy expenditure and excess weight. Med. 2024 Sep 13; 5(9):1083-1095.e6. PMID: 38906141.
Read at: PubMed - Published on 6/4/2024
Joynt Maddox KE, Elkind MSV, Aparicio HJ, Commodore-Mensah Y, de Ferranti SD, Dowd WN, Hernandez AF, Khavjou O, Michos ED, Palaniappan L, Penko J, Poudel R, Roger VL, Kazi DS. Forecasting the Burden of Cardiovascular Disease and Stroke in the United States Through 2050-Prevalence of Risk Factors and Disease: A Presidential Advisory From the American Heart Association. Circulation. 2024 Jul 23; 150(4):e65-e88. PMID: 38832505.
Read at: PubMed
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