George T. O’Connor, MD

Professor, Medicine

George O'Connor
72 E. Concord St Housman (R)


My research focuses on epidemiology, including genetic epidemiology, and clinical investigations of asthma, allergy, chronic obstructive pulmonary disease, and sleep apnea. I have been the Boston University / Boston Medical Center principal investigator of multiple NIH-funded multi-center investigations, currently including the Inner-City Asthma Consortium (ICAC), the Vitamin D Antenatal Asthma Reduction Trial (VDAART), and the All of Us Research Program. Our ICAC studies include clinical trials in children and adolescents with asthma and a birth-cohort study examining the risk factors for asthma and allergy in the inner city. I also conduct epidemiologic and genetic epidemiologic research at the Framingham Heart Study, including genome-wide association studies seeking novel genetic determinants of lung function impairment, interstitial lung abnormalities, and atopy. I have collaborated with the Division of Computational Biomedicine’s studies of alterations in gene expression related to tobacco smoking and COPD. My research spans disciplines including adult medicine, pediatrics, obstetrics, epidemiology, genetics and genomics, immunology, and environmental science. At Boston Medical Center, my outpatient practice focuses on adults with asthma, COPD, and bronchiectasis. I am an Associate Editor of JAMA.

Other Positions

  • Investigator, Framingham Heart Study
  • Member, Pulmonary Center, Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
  • Member, Genome Science Institute, Boston University


  • Boston University School of Medicine, MD
  • Harvard School of Public Health, MS
  • Boston University, BA


  • Published on 3/15/2021

    Terzikhan N, Xu H, Edris A, Bracke KR, Verhamme FM, Stricker BHC, Dupuis J, Lahousse L, O'Connor GT, Brusselle GG. Epigenome-wide association study on diffusing capacity of the lung. ERJ Open Res. 2021 Jan; 7(1). PMID: 33748261.

    Read at: PubMed
  • Published on 3/10/2021

    Altman MC, Calatroni A, Ramratnam S, Jackson DJ, Presnell S, Rosasco MG, Gergen PJ, Bacharier LB, O'Connor GT, Sandel MT, Kattan M, Wood RA, Visness CM, Gern JE. Endotype of Allergic Asthma with Airway Obstruction in Urban Children. J Allergy Clin Immunol. 2021 Mar 10. PMID: 33713771.

    Read at: PubMed
  • Published on 3/10/2021

    Ramratnam S, Lockhart A, Visness CM, Calatroni A, Jackson DJ, Gergen PJ, Bacharier LB, O'Connor GT, Sandel MT, Kattan M, Wood RA, Gern JE. Maternal Stress and Depression are Associatedwith Respiratory Phenotypes in Urban Children. J Allergy Clin Immunol. 2021 Mar 10. PMID: 33713764.

    Read at: PubMed
  • Published on 2/16/2021

    Yola IM, Oh A, Mitchell GF, O'Connor G, Cheng S, Vasan RS, Xanthakis V. Association of lung diffusion capacity with cardiac remodeling and risk of heart failure: The Framingham heart study. PLoS One. 2021; 16(2):e0246355. PMID: 33592021.

    Read at: PubMed
  • Published on 2/3/2021

    Hallmark B, Wegienka G, Havstad S, Billheimer D, Ownby D, Mendonca EA, Gress L, Stern DA, Myers JB, Khurana Hershey GK, Hoepner L, Miller RL, Lemanske RF, Jackson DJ, Gold DR, O'Connor GT, Nicolae DL, Gern JE, Ober C, Wright AL, Martinez FD. Chromosome 17q12-21 Variants are Associated with Multiple Wheezing Phenotypes in Childhood. Am J Respir Crit Care Med. 2021 Feb 03. PMID: 33535024.

    Read at: PubMed
  • Published on 1/22/2021

    Knihtilä HM, Stubbs BJ, Carey VJ, Laranjo N, Chu SH, Kelly RS, Zeiger RS, Bacharier LB, O'Connor GT, Lasky-Su J, Weiss ST, Litonjua AA. Low gestational vitamin D level and childhood asthma are related to impaired lung function in high-risk children. J Allergy Clin Immunol. 2021 Jan 22. PMID: 33485958.

    Read at: PubMed
  • Published on 1/15/2021

    Synn AJ, Li W, San José Estépar R, Washko GR, O'Connor GT, Tsao CW, Mittleman MA, Rice MB. Pulmonary Vascular Pruning on Computed Tomography and Risk of Death in the Framingham Heart Study. Am J Respir Crit Care Med. 2021 01 15; 203(2):251-254. PMID: 32926788.

    Read at: PubMed
  • Published on 1/4/2021

    Kim JS, Steffen BT, Podolanczuk AJ, Kawut SM, Noth I, Raghu G, Michos ED, Hoffman EA, Axelsson GT, Gudmundsson G, Gudnason V, Gudmundsson EF, Murphy RA, Dupuis J, Xu H, Vasan RS, O'Connor GT, Harris WS, Hunninghake GM, Barr RG, Tsai MY, Lederer DJ. Associations of ?-3 Fatty Acids With Interstitial Lung Disease and Lung Imaging Abnormalities Among Adults. Am J Epidemiol. 2021 01 04; 190(1):95-108. PMID: 32803215.

    Read at: PubMed
  • Published on 12/29/2020

    Parikh R, Rao SR, Kukde R, O'Connor GT, Patel A, Hibberd PL. Assessing the Respiratory Effects of Air Pollution from Biomass Cookstoves on Pregnant Women in Rural India. Int J Environ Res Public Health. 2020 12 29; 18(1). PMID: 33383756.

    Read at: PubMed
  • Published on 12/8/2020

    Lovinsky-Desir S, O'Connor GT. Evolving Strategies for Long-term Asthma Management. JAMA. 2020 12 08; 324(22):2265-2267. PMID: 33270088.

    Read at: PubMed

View 261 more publications: View full profile at BUMC

View all profiles