George T. O’Connor, MD

Professor, Medicine

George O'Connor
72 E. Concord St Housman (R)

Biography

My research focuses on epidemiology, including genetic epidemiology, and clinical investigations of asthma, allergy, chronic obstructive pulmonary disease, and sleep apnea. I have been the Boston University / Boston Medical Center principal investigator of multiple NIH-funded multi-center investigations, currently including the Inner-City Asthma Consortium (ICAC), the Vitamin D Antenatal Asthma Reduction Trial (VDAART), and the All of Us Research Program. Our ICAC studies include clinical trials in children and adolescents with asthma and a birth-cohort study examining the risk factors for asthma and allergy in the inner city. I also conduct epidemiologic and genetic epidemiologic research at the Framingham Heart Study, including genome-wide association studies seeking novel genetic determinants of lung function impairment, interstitial lung abnormalities, and atopy. I have collaborated with the Division of Computational Biomedicine’s studies of alterations in gene expression related to tobacco smoking and COPD. My research spans disciplines including adult medicine, pediatrics, obstetrics, epidemiology, genetics and genomics, immunology, and environmental science. At Boston Medical Center, my outpatient practice focuses on adults with asthma, COPD, and bronchiectasis. I am an Associate Editor of JAMA.

Other Positions

  • Investigator, Framingham Heart Study
  • Member, Pulmonary Center, Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
  • Member, Genome Science Institute, Boston University

Education

  • Boston University School of Medicine, MD
  • Harvard School of Public Health, MS
  • Boston University, BA

Publications

  • Published on 2/20/2022

    Lee-Sarwar K, Dedrick S, Momeni B, Kelly RS, Zeiger RS, O'Connor GT, Sandel MT, Bacharier LB, Beigelman A, Laranjo N, Gold DR, Lasky-Su J, Litonjua AA, Liu YY, Weiss ST. Association of the gut microbiome and metabolome with wheeze frequency in childhood asthma. J Allergy Clin Immunol. 2022 Feb 20. PMID: 35196534.

    Read at: PubMed
  • Published on 2/17/2022

    Bhatt SP, Balte PP, Schwartz JE, Jaeger BC, Cassano PA, Chaves PH, Couper D, Jacobs DR, Kalhan R, Kaplan R, Lloyd-Jones D, Newman AB, O'Connor G, Sanders JL, Smith BM, Sun Y, Umans JG, White WB, Yende S, Oelsner EC. Pooled Cohort Probability Score for Subclinical Airflow Obstruction. Ann Am Thorac Soc. 2022 Feb 17. PMID: 35176216.

    Read at: PubMed
  • Published on 2/8/2022

    McCauley KE, Flynn K, Calatroni A, DiMassa V, LaMere B, Fadrosh DW, Lynch KV, Gill MA, Pongracic JA, Khurana Hershey GK, Kercsmar CM, Liu AH, Johnson CC, Kim H, Kattan M, O'Connor GT, Bacharier LB, Teach SJ, Gergen PJ, Wheatley LM, Togias A, LeBeau P, Presnell S, Boushey HA, Busse WW, Gern JE, Jackson DJ, Altman MC, Lynch SV. Seasonal airway microbiome and transcriptome interactions promote childhood asthma exacerbations. J Allergy Clin Immunol. 2022 Feb 08. PMID: 35149044.

    Read at: PubMed
  • Published on 2/3/2022

    Putman RK, Axelsson GT, Ash SY, Sanders JL, Menon AA, Araki T, Nishino M, Yanagawa M, Gudmundsson EF, Qiao D, San José Estépar R, Dupuis J, O'Connor GT, Rosas IO, Washko GR, El-Chemaly S, Raby BA, Gudnason V, DeMeo DL, Silverman EK, Hatabu H, DeVivo I, Cho MH, Gudmundsson G, Hunninghake GM. Interstitial lung abnormalities are associated with decreased mean telomere length. Eur Respir J. 2022 Feb 03. PMID: 35115336.

    Read at: PubMed
  • Published on 2/3/2022

    Zhang J, Xu H, Qiao D, DeMeo DL, Silverman EK, O'Connor GT, Hobbs BD, Dupuis J, Cho MH, Moll M. A Polygenic Risk Score and Age of Diagnosis of Chronic Obstructive Pulmonary Disease. Eur Respir J. 2022 Feb 03. PMID: 35115341.

    Read at: PubMed
  • Published on 1/20/2022

    Miller PG, Qiao D, Rojas-Quintero J, Honigberg MC, Sperling AS, Gibson CJ, Bick AG, Niroula A, McConkey ME, Sandoval B, Miller BC, Shi W, Viswanathan K, Leventhal M, Werner L, Moll M, Cade BE, Barr RG, Correa A, Cupples LA, Gharib SA, Jain D, Gogarten SM, Lange LA, London SJ, Manichaikul A, O'Connor GT, Oelsner EC, Redline S, Rich SS, Rotter JI, Ramachandran V, Yu B, Sholl L, Neuberg D, Jaiswal S, Levy BD, Owen CA, Natarajan P, Silverman EK, van Galen P, Tesfaigzi Y, Cho MH, Ebert BL. Association of clonal hematopoiesis with chronic obstructive pulmonary disease. Blood. 2022 01 20; 139(3):357-368. PMID: 34855941.

    Read at: PubMed
  • Published on 1/7/2022

    McNeill J, Chernofsky A, Nayor M, Rahaghi FN, San Jose Estepar R, Washko G, Synn A, Vasan RS, O'Connor G, Larson MG, Ho JE, Lewis GD. The association of lung function and pulmonary vasculature volume with cardiorespiratory fitness in the community. Eur Respir J. 2022 Jan 07. PMID: 34996832.

    Read at: PubMed
  • Published on 12/30/2021

    Bui H, Keshawarz A, Hwang SJ, Yao C, Lee GY, Recto K, O'Connor GT, Levy D. A genomic approach identifies sRAGE as a putatively causal protein for asthma. J Allergy Clin Immunol. 2021 Dec 30. PMID: 34974068.

    Read at: PubMed
  • Published on 12/23/2021

    Clark CR, Chandler PD, Zhou G, Noel N, Achilike C, Mendez L, O'Connor GT, Smoller JW, Weiss ST, Murphy SN, Ommerborn MJ, Karnes JH, Klimentidis YC, Jordan CD, Hiatt RA, Ramirez AH, Loperena R, Mayo K, Cohn E, Ohno-Machado L, Boerwinkle E, Cicek M, Schully SD, Mockrin S, Gebo KA, Karlson EW. Geographic Variation in Obesity at the State Level in the All of Us Research Program. Prev Chronic Dis. 2021 12 23; 18:E104. PMID: 34941480.

    Read at: PubMed
  • Published on 12/14/2021

    Wan ES, Balte P, Schwartz JE, Bhatt SP, Cassano PA, Couper D, Daviglus ML, Dransfield MT, Gharib SA, Jacobs DR, Kalhan R, London SJ, Navas-Acien A, O'Connor GT, Sanders JL, Smith BM, White W, Yende S, Oelsner EC. Association Between Preserved Ratio Impaired Spirometry and Clinical Outcomes in US Adults. JAMA. 2021 12 14; 326(22):2287-2298. PMID: 34905031.

    Read at: PubMed

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