George T. O’Connor, MD

Professor, Medicine

George O'Connor
72 E. Concord St Housman (R)

Biography

My research focuses on epidemiology, including genetic epidemiology, and clinical investigations of asthma, allergy, chronic obstructive pulmonary disease, and sleep apnea. I have been the Boston University / Boston Medical Center principal investigator of multiple NIH-funded multi-center investigations, currently including the Inner-City Asthma Consortium (ICAC), the Vitamin D Antenatal Asthma Reduction Trial (VDAART), and the All of Us Research Program. Our ICAC studies include clinical trials in children and adolescents with asthma and a birth-cohort study examining the risk factors for asthma and allergy in the inner city. I also conduct epidemiologic and genetic epidemiologic research at the Framingham Heart Study, including genome-wide association studies seeking novel genetic determinants of lung function impairment, interstitial lung abnormalities, and atopy. I have collaborated with the Division of Computational Biomedicine’s studies of alterations in gene expression related to tobacco smoking and COPD. My research spans disciplines including adult medicine, pediatrics, obstetrics, epidemiology, genetics and genomics, immunology, and environmental science. At Boston Medical Center, my outpatient practice focuses on adults with asthma, COPD, and bronchiectasis. I am an Associate Editor of JAMA.

Other Positions

  • Active Staff Privileges, Medicine, Boston Medical Center
  • Framingham Heart Study

Education

  • Boston University School of Medicine, MD
  • Harvard School of Public Health, MS
  • Boston University, BA

Publications

  • Published on 9/12/2019

    Synn AJ, Li W, San José Estépar R, Zhang C, Washko GR, O'Connor GT, Araki T, Hatabu H, Bankier AA, Mittleman MA, Rice MB. Radiographic pulmonary vessel volume, lung function and airways disease in the Framingham Heart Study. Eur Respir J. 2019 Sep; 54(3). PMID: 31248956.

    Read at: PubMed
  • Published on 9/5/2019

    Lee-Sarwar KA, Kelly RS, Lasky-Su J, Zeiger RS, O'Connor GT, Sandel MT, Bacharier LB, Beigelman A, Rifas-Shiman SL, Carey VJ, Harshfield BJ, Laranjo N, Gold DR, Weiss ST, Litonjua AA. Fecal Short-Chain Fatty Acids in Pregnancy and Offspring Asthma and Allergic Outcomes. J Allergy Clin Immunol Pract. 2019 Sep 05. PMID: 31494295.

    Read at: PubMed
  • Published on 9/1/2019

    Mirzakhani H, Carey VJ, McElrath TF, Hollis BW, O'Connor GT, Zeiger RS, Bacharier L, Litonjua AA, Weiss ST. Maternal Asthma, Preeclampsia, and Risk for Childhood Asthma at Age Six. Am J Respir Crit Care Med. 2019 Sep 01; 200(5):638-642. PMID: 31059286.

    Read at: PubMed
  • Published on 8/7/2019

    Rice MB, Li W, Schwartz J, Di Q, Kloog I, Koutrakis P, Gold DR, Hallowell RW, Zhang C, O'Connor G, Washko GR, Hunninghake GM, Mittleman MA. Ambient air pollution exposure and risk and progression of interstitial lung abnormalities: the Framingham Heart Study. Thorax. 2019 Aug 07. PMID: 31391318.

    Read at: PubMed
  • Published on 7/24/2019

    Hobbs BD, Putman RK, Araki T, Nishino M, Gudmundsson G, Gudnason V, Eiriksdottir G, Zilhao Nogueira NR, Dupuis J, Xu H, O'Connor GT, Manichaikul A, Nguyen J, Podolanczuk AJ, Madahar P, Rotter JI, Lederer DJ, Barr RG, Rich SS, Ampleford EJ, Ortega VE, Peters SP, O'Neal WK, Newell JD, Bleecker ER, Meyers DA, Allen RJ, Oldham JM, Ma SF, Noth I, Jenkins RG, Maher TM, Hubbard RB, Wain LV, Fingerlin TE, Schwartz DA, Washko GR, Rosas IO, Silverman EK, Hatabu H, Cho MH, Hunninghake GM. Overlap of Genetic Risk Between Interstitial Lung Abnormalities and Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2019 Jul 24. PMID: 31339356.

    Read at: PubMed
  • Published on 6/25/2019

    Bhatt SP, Balte PP, Schwartz JE, Cassano PA, Couper D, Jacobs DR, Kalhan R, O'Connor GT, Yende S, Sanders JL, Umans JG, Dransfield MT, Chaves PH, White WB, Oelsner EC. Discriminative Accuracy of FEV1:FVC Thresholds for COPD-Related Hospitalization and Mortality. JAMA. 2019 06 25; 321(24):2438-2447. PMID: 31237643.

    Read at: PubMed
  • Published on 6/22/2019

    Corbett SE, Nitzberg M, Moses E, Kleerup E, Wang T, Perdomo C, Perdomo C, Liu G, Xiao X, Liu H, Elashoff DA, Brooks DR, O'Connor GT, Dubinett SM, Spira A, Lenburg ME. Gene Expression Alterations in the Bronchial Epithelium of e-Cigarette Users. Chest. 2019 Jun 22. PMID: 31233743.

    Read at: PubMed
  • Published on 6/13/2019

    Pomés A, Glesner J, Calatroni A, Visness CM, Wood RA, O'Connor GT, Kattan M, Bacharier LB, Wheatley LM, Gern JE, Busse WW. Cockroach allergen component analysis of children with or without asthma and rhinitis in an inner-city birth cohort. J Allergy Clin Immunol. 2019 Jun 13. PMID: 31201891.

    Read at: PubMed
  • Published on 6/10/2019

    Gern JE, Jackson DJ, Lemanske RF, Seroogy CM, Tachinardi U, Craven M, Hwang SY, Hamilton CM, Huggins W, O'Connor GT, Gold DR, Miller R, Kattan M, Johnson CC, Ownby D, Zoratti EM, Wood RA, Visness CM, Martinez F, Wright A, Lynch S, Ober C, Khurana Hershey GK, Ryan P, Hartert T, Bacharier LB. The Children's Respiratory and Environmental Workgroup (CREW) birth cohort consortium: design, methods, and study population. Respir Res. 2019 Jun 10; 20(1):115. PMID: 31182091.

    Read at: PubMed
  • Published on 6/1/2019

    Synn AJ, Zhang C, Washko GR, Estépar RSJ, O'Connor GT, Li W, Mittleman MA, Rice MB. Cigarette Smoke Exposure and Radiographic Pulmonary Vascular Morphology in the Framingham Heart Study. Ann Am Thorac Soc. 2019 Jun; 16(6):698-706. PMID: 30714821.

    Read at: PubMed

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