George T. O’Connor, MD

Professor, Medicine

George O'Connor
72 E. Concord St Housman (R)

Biography

My research focuses on epidemiology, including genetic epidemiology, and clinical investigations of asthma, allergy, chronic obstructive pulmonary disease, and sleep apnea. I have been the Boston University / Boston Medical Center principal investigator of multiple NIH-funded multi-center investigations, currently including the Inner-City Asthma Consortium (ICAC), the Vitamin D Antenatal Asthma Reduction Trial (VDAART), and the All of Us Research Program. Our ICAC studies include clinical trials in children and adolescents with asthma and a birth-cohort study examining the risk factors for asthma and allergy in the inner city. I also conduct epidemiologic and genetic epidemiologic research at the Framingham Heart Study, including genome-wide association studies seeking novel genetic determinants of lung function impairment, interstitial lung abnormalities, and atopy. I have collaborated with the Division of Computational Biomedicine’s studies of alterations in gene expression related to tobacco smoking and COPD. My research spans disciplines including adult medicine, pediatrics, obstetrics, epidemiology, genetics and genomics, immunology, and environmental science. At Boston Medical Center, my outpatient practice focuses on adults with asthma, COPD, and bronchiectasis. I am an Associate Editor of JAMA.

Other Positions

  • Investigator, Framingham Heart Study
  • Member, Pulmonary Center, Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
  • Member, Genome Science Institute, Boston University

Education

  • Boston University School of Medicine, MD
  • Harvard School of Public Health, MS
  • Boston University, BA

Publications

  • Published on 5/4/2020

    Nayor M, Xanthakis V, Tanguay M, Blodgett JB, Shah RV, Schoenike M, Sbarbaro J, Farrell R, Malhotra R, Houstis NE, Velagaleti RS, Moore SA, Baggish AL, O'Connor GT, Ho JE, Larson MG, Vasan RS, Lewis GD. Clinical and Hemodynamic Associations and Prognostic Implications of Ventilatory Efficiency in Patients With Preserved Left Ventricular Systolic Function. Circ Heart Fail. 2020 May; 13(5):e006729. PMID: 32362167.

    Read at: PubMed
  • Published on 5/1/2020

    Ober C, McKennan CG, Magnaye KM, Altman MC, Washington C, Stanhope C, Naughton KA, Rosasco MG, Bacharier LB, Billheimer D, Gold DR, Gress L, Hartert T, Havstad S, Khurana Hershey GK, Hallmark B, Hogarth DK, Jackson DJ, Johnson CC, Kattan M, Lemanske RF, Lynch SV, Mendonca EA, Miller RL, Naureckas ET, O'Connor GT, Seroogy CM, Wegienka G, White SR, Wood RA, Wright AL, Zoratti EM, Martinez FD, Ownby D, Nicolae DL, Levin AM, Gern JE. Expression quantitative trait locus fine mapping of the 17q12-21 asthma locus in African American children: a genetic association and gene expression study. Lancet Respir Med. 2020 May; 8(5):482-492. PMID: 32380068.

    Read at: PubMed
  • Published on 4/22/2020

    Jackson DJ, Busse WW, Bacharier LB, Kattan M, O'Connor GT, Wood RA, Visness CM, Durham SR, Larson D, Esnault S, Ober C, Gergen PJ, Becker P, Togias A, Gern JE, Altman MC. Association of respiratory allergy, asthma, and expression of the SARS-CoV-2 receptor ACE2. J Allergy Clin Immunol. 2020 Apr 22. PMID: 32333915.

    Read at: PubMed
  • Published on 4/21/2020

    Bou Jawde S, Walkey AJ, Majumdar A, O'Connor GT, Smith BJ, Bates JHT, Lutchen KR, Suki B. Tracking respiratory mechanics around natural breathing rates via variable ventilation. Sci Rep. 2020 Apr 21; 10(1):6722. PMID: 32317734.

    Read at: PubMed
  • Published on 4/14/2020

    Cornelius T, Schwartz JE, Balte P, Bhatt SP, Cassano PA, Currow D, Jacobs DR, Johnson M, Kalhan R, Kronmal R, Loehr L, O'Connor GT, Smith B, White WB, Yende S, Oelsner EC. A Dyadic Growth Modeling Approach to Examine Associations Between Weight Gain and Lung Function Decline: The NHLBI Pooled Cohorts Study. Am J Epidemiol. 2020 Apr 14. PMID: 32286615.

    Read at: PubMed
  • Published on 3/2/2020

    Balte PP, Chaves PHM, Couper DJ, Enright P, Jacobs DR, Kalhan R, Kronmal RA, Loehr LR, London SJ, Newman AB, O'Connor GT, Schwartz JE, Smith BM, Smith LJ, White WB, Yende S, Oelsner EC. Association of Nonobstructive Chronic Bronchitis With Respiratory Health Outcomes in Adults. JAMA Intern Med. 2020 Mar 02. PMID: 32119036.

    Read at: PubMed
  • Published on 3/1/2020

    Allen RJ, Guillen-Guio B, Oldham JM, Ma SF, Dressen A, Paynton ML, Kraven LM, Obeidat M, Li X, Ng M, Braybrooke R, Molina-Molina M, Hobbs BD, Putman RK, Sakornsakolpat P, Booth HL, Fahy WA, Hart SP, Hill MR, Hirani N, Hubbard RB, McAnulty RJ, Millar AB, Navaratnam V, Oballa E, Parfrey H, Saini G, Whyte MKB, Zhang Y, Kaminski N, Adegunsoye A, Strek ME, Neighbors M, Sheng XR, Gudmundsson G, Gudnason V, Hatabu H, Lederer DJ, Manichaikul A, Newell JD, O'Connor GT, Ortega VE, Xu H, Fingerlin TE, Bossé Y, Hao K, Joubert P, Nickle DC, Sin DD, Timens W, Furniss D, Morris AP, Zondervan KT, Hall IP, Sayers I, Tobin MD, Maher TM, Cho MH, Hunninghake GM, Schwartz DA, Yaspan BL, Molyneaux PL, Flores C, Noth I, Jenkins RG, Wain LV. Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2020 03 01; 201(5):564-574. PMID: 31710517.

    Read at: PubMed
  • Published on 2/11/2020

    Zoratti EM, O'Connor GT. New Therapeutic Strategies for Asthma. JAMA. 2020 02 11; 323(6):517-518. PMID: 32044924.

    Read at: PubMed
  • Published on 2/6/2020

    Litonjua AA, Carey VJ, Laranjo N, Stubbs BJ, Mirzakhani H, O'Connor GT, Sandel M, Beigelman A, Bacharier LB, Zeiger RS, Schatz M, Hollis BW, Weiss ST. Six-Year Follow-up of a Trial of Antenatal Vitamin D for Asthma Reduction. N Engl J Med. 2020 02 06; 382(6):525-533. PMID: 32023372.

    Read at: PubMed
  • Published on 1/28/2020

    Jackson DJ, Bacharier LB, Calatroni A, Gill MA, Hu J, Liu AH, Wheatley LM, Gern JE, Gruchalla RS, Khurana Hershey GK, Kattan M, Kercsmar CM, Kim H, O'Connor GT, Patel S, Pongracic JA, Wood RA, Busse WW. Serum IL-6: A biomarker in childhood asthma? J Allergy Clin Immunol. 2020 Jun; 145(6):1701-1704.e3. PMID: 32004524.

    Read at: PubMed

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