Gareth J Morgan, PhD

Research Assistant Professor, Medicine

Gareth Morgan
617.358.4750

Biography

Gareth Morgan, PhD is a Research Assistant Professor at the Boston University School of Medicine. His research focuses on the molecular mechanisms of AL amyloidosis with the aim of developing new treatments for this disease.

Other Positions

  • Member, BU-BMC Cancer Center, Boston University
  • Member, Amyloidosis Center, Boston University
  • Member, Genome Science Institute, Boston University
  • Graduate Faculty (Primary Mentor of Grad Students) , Boston University School of Medicine, Graduate Medical Sciences

Education

  • University of Sheffield, PhD
  • Imperial College London, BS

Publications

  • Published on 1/19/2022

    Yan NL, Nair R, Chu A, Wilson IA, Johnson KA, Morgan GJ, Kelly JW. Amyloidogenic immunoglobulin light chain kinetic stabilizers comprising a simple urea linker module reveal a novel binding sub-site. Bioorg Med Chem Lett. 2022 03 15; 60:128571. PMID: 35065233.

    Read at: PubMed
  • Published on 10/30/2021

    Morgan GJ. Transient disorder along pathways to amyloid. Biophys Chem. 2022 02; 281:106711. PMID: 34839162.

    Read at: PubMed
  • Published on 10/5/2021

    Morgan GJ, Buxbaum JN, Kelly JW. Light Chain Stabilization: A Therapeutic Approach to Ameliorate AL Amyloidosis. Hemato. 2021 Dec; 2(4):645-659. PMID: 35757512.

    Read at: PubMed
  • Published on 6/11/2021

    Morgan GJ. Barriers to Small Molecule Drug Discovery for Systemic Amyloidosis. Molecules. 2021 Jun 11; 26(12). PMID: 34208058.

    Read at: PubMed
  • Published on 5/3/2021

    Yan NL, Santos-Martins D, Nair R, Chu A, Wilson IA, Johnson KA, Forli S, Morgan GJ, Petrassi HM, Kelly JW. Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design. J Med Chem. 2021 05 13; 64(9):6273-6299. PMID: 33939422.

    Read at: PubMed
  • Published on 9/12/2020

    Morgan GJ, Wall JS. The Process of Amyloid Formation due to Monoclonal Immunoglobulins. Hematol Oncol Clin North Am. 2020 12; 34(6):1041-1054. PMID: 33099422.

    Read at: PubMed
  • Published on 6/16/2020

    Yan NL, Santos-Martins D, Rennella E, Sanchez BB, Chen JS, Kay LE, Wilson IA, Morgan GJ, Forli S, Kelly JW. Structural basis for the stabilization of amyloidogenic immunoglobulin light chains by hydantoins. Bioorg Med Chem Lett. 2020 08 15; 30(16):127356. PMID: 32631553.

    Read at: PubMed
  • Published on 8/14/2019

    Rennella E, Morgan GJ, Yan N, Kelly JW, Kay LE. The Role of Protein Thermodynamics and Primary Structure in Fibrillogenesis of Variable Domains from Immunoglobulin Light Chains. J Am Chem Soc. 2019 08 28; 141(34):13562-13571. PMID: 31364359.

    Read at: PubMed
  • Published on 4/10/2019

    Morgan GJ, Yan NL, Mortenson DE, Rennella E, Blundon JM, Gwin RM, Lin CY, Stanfield RL, Brown SJ, Rosen H, Spicer TP, Fernandez-Vega V, Merlini G, Kay LE, Wilson IA, Kelly JW. Stabilization of amyloidogenic immunoglobulin light chains by small molecules. Proc Natl Acad Sci U S A. 2019 04 23; 116(17):8360-8369. PMID: 30971495.

    Read at: PubMed
  • Published on 12/31/2018

    Rennella E, Morgan GJ, Kelly JW, Kay LE. Role of domain interactions in the aggregation of full-length immunoglobulin light chains. Proc Natl Acad Sci U S A. 2019 01 15; 116(3):854-863. PMID: 30598439.

    Read at: PubMed

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