Gareth J Morgan, PhD

Research Assistant Professor, Medicine

Gareth Morgan
617.358.4750

Biography

Gareth Morgan, PhD is a Research Assistant Professor at the Boston University School of Medicine. His research focuses on the molecular mechanisms of AL amyloidosis with the aim of developing new treatments for this disease.

Other Positions

  • Member, BU-BMC Cancer Center, Boston University
  • Member, Amyloidosis Center, Boston University
  • Member, Genome Science Institute, Boston University

Education

  • University of Sheffield, PhD
  • Imperial College London, BS

Publications

  • Published on 6/16/2020

    Yan NL, Santos-Martins D, Rennella E, Sanchez BB, Chen JS, Kay LE, Wilson IA, Morgan GJ, Forli S, Kelly JW. Structural basis for the stabilization of amyloidogenic immunoglobulin light chains by hydantoins. Bioorg Med Chem Lett. 2020 Aug 15; 30(16):127356. PMID: 32631553.

    Read at: PubMed
  • Published on 8/14/2019

    Rennella E, Morgan GJ, Yan N, Kelly JW, Kay LE. The Role of Protein Thermodynamics and Primary Structure in Fibrillogenesis of Variable Domains from Immunoglobulin Light Chains. J Am Chem Soc. 2019 08 28; 141(34):13562-13571. PMID: 31364359.

    Read at: PubMed
  • Published on 4/10/2019

    Morgan GJ, Yan NL, Mortenson DE, Rennella E, Blundon JM, Gwin RM, Lin CY, Stanfield RL, Brown SJ, Rosen H, Spicer TP, Fernandez-Vega V, Merlini G, Kay LE, Wilson IA, Kelly JW. Stabilization of amyloidogenic immunoglobulin light chains by small molecules. Proc Natl Acad Sci U S A. 2019 04 23; 116(17):8360-8369. PMID: 30971495.

    Read at: PubMed
  • Published on 12/31/2018

    Rennella E, Morgan GJ, Kelly JW, Kay LE. Role of domain interactions in the aggregation of full-length immunoglobulin light chains. Proc Natl Acad Sci U S A. 2019 01 15; 116(3):854-863. PMID: 30598439.

    Read at: PubMed
  • Published on 3/1/2018

    Buxbaum JN, Morgan GJ. Summary: FASEB Science Research Conference on Protein Aggregation in Health and Disease. FASEB J. 2018 03; 32(3):1125-1129. PMID: 29521540.

    Read at: PubMed
  • Published on 3/1/2018

    Buxbaum JN, Morgan GJ. Summary: FASEB Science Research Conference on Protein Aggregation in Health and Disease June 11-16, 2017, Steamboat Springs, Colorado, USA. FASEB J. 2018 Mar; 32(3):1125-1129. PMID: 32172544.

    Read at: PubMed
  • Published on 12/4/2017

    Morgan GJ, Usher GA, Kelly JW. Incomplete Refolding of Antibody Light Chains to Non-Native, Protease-Sensitive Conformations Leads to Aggregation: A Mechanism of Amyloidogenesis in Patients? Biochemistry. 2017 Dec 19; 56(50):6597-6614. PMID: 29200282.

    Read at: PubMed
  • Published on 11/28/2017

    Morgan GJ, Burkhardt DH, Kelly JW, Powers ET. Translation efficiency is maintained at elevated temperature in Escherichia coli. J Biol Chem. 2018 01 19; 293(3):777-793. PMID: 29183994.

    Read at: PubMed
  • Published on 2/27/2017

    Jin HY, Oda H, Chen P, Yang C, Zhou X, Kang SG, Valentine E, Kefauver JM, Liao L, Zhang Y, Gonzalez-Martin A, Shepherd J, Morgan GJ, Mondala TS, Head SR, Kim PH, Xiao N, Fu G, Liu WH, Han J, Williamson JR, Xiao C. Differential Sensitivity of Target Genes to Translational Repression by miR-17~92. PLoS Genet. 2017 02; 13(2):e1006623. PMID: 28241004.

    Read at: PubMed
  • Published on 8/26/2016

    Morgan GJ, Kelly JW. The Kinetic Stability of a Full-Length Antibody Light Chain Dimer Determines whether Endoproteolysis Can Release Amyloidogenic Variable Domains. J Mol Biol. 2016 10 23; 428(21):4280-4297. PMID: 27569045.

    Read at: PubMed

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