G. G. Shipley, PhD, DSc

Emeritus Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Dr. Shipley is Emeritus Professor of Physiology and Biophysics at Chobanian and Avedisian School of Medicine. His research interests center around the structure and function of cell membranes, receptor-ligand interactions and transmembrane signaling mechanisms. A combination of biochemical, chemical and biophysical approaches are used to probe: (1) membrane lipid conformation, structure, properties and interactions, (2) membrane receptor-lipid interactions and (3) membrane receptor-ligand interactions. Current approaches involve the isolation of membrane-associated proteins and lipids (e.g. low density lipoprotein (LDL) receptor, insulin receptor, integrins, gangliosides), their reconstitution with well characterized lipid monolayer and bilayer matrices and structural studies of the protein-lipid assemblies. Ligand binding studes include LDL receptor/LDL, insulin receptor/insulin, and ganglioside/toxin interactions. The biochemical methods involved include lipid and protein isolation, gel/affinity chromatography, antibody techniques, immunoblotting, detergent solubilization, lipid-protein reconstitution, etc. Chemical methods include lipid sythesis, TLC, HPLC, IR and NMR. The biophysical approach involves x-ray diffraction, protein crystallography, electron microscopy/image reconstruction, surface chemistry and calorimetric and spectroscopic (CD, NMR) methods.

Publications

  • Published 9/3/2020

    Shipley GG, Tall AR, Atkinson D. In Memoriam: Donald MacFarland Small (1931-2019). J Lipid Res. 2019 May; 60(5):911-912. PMID: 33722375.

    Read at: PubMed

  • Published 8/24/2009

    Doyle DA, Shipley GG. Membranes: editorial overview. Curr Opin Struct Biol. 2009 Aug; 19(4):369-71. PMID: 19709877.

    Read at: PubMed

  • Published 9/29/2000

    Jeon H, Shipley GG. Vesicle-reconstituted low density lipoprotein receptor. Visualization by cryoelectron microscopy. J Biol Chem. 2000 Sep 29; 275(39):30458-64. PMID: 10889196.

    Read at: PubMed

  • Published 9/29/2000

    Jeon H, Shipley GG. Localization of the N-terminal domain of the low density lipoprotein receptor. J Biol Chem. 2000 Sep 29; 275(39):30465-70. PMID: 10889195.

    Read at: PubMed

  • Published 8/1/2000

    Shipley GG. Bilayers and nonbilayers: structure, forces and protein crystallization. Curr Opin Struct Biol. 2000 Aug; 10(4):471-3. PMID: 10981637.

    Read at: PubMed

Other Positions

  • Graduate Faculty (Primary Mentor of Grad Students)
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
  • Professor, Biochemistry & Cell Biology
    Boston University Chobanian & Avedisian School of Medicine

Education

  • University of Nottingham, PhD
  • University of Nottingham, BSc