Frederick L. Ruberg, MD - Chief, Cardiovascular Medicine

Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Frederick L. Ruberg, MD is the Thomas J. Ryan Professor of Cardiovascular Medicine and Professor of Radiology at Boston University (BU) Chobanian & Avedisian School of Medicine and Chief, Section of Cardiovascular Medicine at Boston Medical Center (BMC). Dr. Ruberg attended the University of Pennsylvania Perelman School of Medicine, completed internal medicine training at Brigham and Women’s Hospital, cardiovascular disease fellowship at Boston Medical Center/Boston University School of Medicine, followed by a fellowship in cardiovascular magnetic resonance (CMR) imaging at Beth Israel Deaconess Medical Center in Boston. Committed to research mentorship, he co-directs Workforce Development for the Boston University Clinical and Translational Science Institute (CTSI) and serves as Senior Associate Editor of Circulation: Cardiovascular Imaging. Dr. Ruberg is a Fellow of the American Heart Association and a member of the Association of University Cardiologists. His clinical and research expertise primarily involves cardiac imaging and infiltrative heart disease focused on improving the recognition and care of patients with cardiac amyloidosis, particularly that owing to ATTR and the hereditary genetic TTR variant Val122Ile (or V142I). He is an investigator on numerous NIH-funded awards including co-PI of the $7.2m NHLBI-funded Screening for Cardiac Amyloidosis with Nuclear Imaging (SCAN-MP, R01 HL139671) study. An active clinical cardiologist at the BU Amyloidosis Center, he has also contributed and co-directed numerous collaborative clinical guidelines initiatives, including mostly recently the 2023 the ACC Expert Consensus Decision Pathway document on The Comprehensive Multidisciplinary Care of Patient with Cardiac Amyloidosis. Dr. Ruberg has been recognized with mentorship (2017) and citizenship (2022) awards from the BU Department of Medicine.

Publications

  • Published 10/22/2025

    Slivnick JA, Hawkes W, Oliveira J, Woodward G, Akerman A, Gomez A, Hamza I, Desai VK, Barrett-O'Keefe Z, Grogan M, Dispenzieri A, Scott CG, Davison HN, Cotella J, Maurer M, Helmke S, Scherrer-Crosbie M, Soltani M, Goyal A, Zareba KM, Cheng RK, Kirkpatrick JN, Kitano T, Takeuchi M, Tiemi Hotta V, Campos Vieira ML, Elissamburu P, Ronderos RE, Prado A, Koutroumpakis E, Deswal A, Pursnani A, Sarswat N, Patel AR, Addetia K, Ruberg FL, Randazzo M, Asch FM, O'Driscoll J, Al-Roub N, Strom JB, Kidd L, Cuddy S, Upton R, Lang RM, Pellikka PA. Cardiac amyloidosis detection from a single echocardiographic video clip: a novel artificial intelligence-based screening tool. Eur Heart J. 2025 Oct 22; 46(40):4090-4101. PMID: 40631729.

    Read at: PubMed

  • Published 10/9/2025

    Wees IR, Ayers C, Ruberg FL, Maurer MS, Brailovsky Y, Stern LK, Griffin JM, Khouri MG, Roth LR, Grodin JL. Clinical Implications of the P.V142I TTR Variant: Insights From CARS. JACC Heart Fail. 2025 Oct 09; 102704. PMID: 41074899.

    Read at: PubMed

  • Published 10/1/2025

    Ruberg FL, Teruya S, Helmke S, Smiley DA, Fine D, Kurian D, Raiszadeh F, Prokaeva T, Spencer B, Wong S, Pandey S, Blaner WS, DeLuca A, Johnson LL, Kinkhabwala MP, Leb J, Mintz A, LaValley MP, Einstein AJ, Cohn E, Gallegos C, Murtagh G, Kelly JW, Miller EJ, Maurer MS. Transthyretin Cardiac Amyloidosis in Older Black and Hispanic Individuals With Heart Failure. JAMA Cardiol. 2025 Oct 01; 10(10):1034-1043. PMID: 40928765.

    Read at: PubMed

  • Published 9/28/2025

    Masri A, Judge DP, Ruberg FL, Gillmore JD, Grodin JL, Obici L, Maurer MS, Fontana M, Poulsen SH, van der Meer P, Cheng RK, Cuddy SAM, Ambardekar AV, Xiong K, Cao X, Murtagh G, Siddhanti S, Castaño A, Tamby JF, Fox JC, Alexander KM, Witteles R. Effect of Acoramidis on Recurrent and Cumulative Cardiovascular Outcomes in ATTR-CM: Exploratory Analysis From ATTRibute-CM. J Am Coll Cardiol. 2025 Sep 28. PMID: 41143759.

    Read at: PubMed

  • Published 9/11/2025

    Benz DC, Clerc OF, Cuddy SAM, Singh V, Kijewski MF, Bianchi G, Yee AJ, Ruberg FL, Jerosch-Herold M, Kwong RY, Di Carli MF, Liao R, Falk RH, Dorbala S. Changes in Myocardial Light Chain Amyloid Burden After Plasma Cell Therapy. JACC Cardiovasc Imaging. 2025 Sep 11. PMID: 40938234.

    Read at: PubMed

View All 161 Publications:   View Full Profile in BUMC

Other Positions

  • Professor, Radiology
    Boston University Chobanian & Avedisian School of Medicine
  • Member, Whitaker Cardiovascular Institute
    Boston University
  • Member, Amyloidosis Center
    Boston University
  • Program Director, Clinical and Translational Science Institute
    Boston University Chobanian & Avedisian School of Medicine

Websites

Education

  • University of Pennsylvania School of Medicine, MD
  • Haverford College, BA

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