Florian Douam, PhD

Assistant Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Florian Douam, Ph.D. is an Assistant Professor of Microbiology at Boston University Chobanian and Avedisian School of Medicine and a core investigator at the National Emerging Infectious Diseases Laboratories (NEIDL). Dr. Douam has a PhD in molecular virology and more than a decade of experience investigating virus biology in cell culture and animal models. Specifically, Dr. Douam is a viral immunologist with deep expertise in generating and using innovative mouse models to investigate viral pathogenesis and immune responses to viruses in BSL-2 and BSL-3 laboratories. At the NEIDL, he leads a research team focused on identifying the molecular and cellular mechanisms shaping immune outcomes in human RNA virus infections, employing a variety of viral pathogens from mosquito-borne viruses to coronaviruses.

Publications

  • Published 6/3/2026

    Soto Albrecht YE, Morrow RM, Kenney D, Olali AZ, Wacquiez A, Chehadeh N, Cen Z, Haltom JA, Chen I, Ranshing SS, Widjaja GA, Angelin A, Tintos-Hernandez JA, Xie W, Potluri P, Lott MT, Zhang S, Saeed M, Murdock DG, Weiss SR, Douam F, Wallace DC. Mitochondrial OXPHOS restricts SARS-CoV-2 replication. Sci Adv. 2026 Jun 05; 12(23):eadz3081. PMID: 42234733.

    Read at: PubMed

  • Published 4/28/2026

    Shastry A, Hiller BE, Sanders NL, Tseng AE, Kothari J, O'connell AK, Gertje HP, Ha CT, Murzin E, Traber KE, Lederer JA, Jones MR, Douam F, Beach TG, Remick DG, Crossland NA, Monti S, Campbell JD, Mizgerd JP. Sub-phenotypes of pneumonia defined by pulmonary histopathological features. Am J Respir Crit Care Med. 2026 Apr 28. PMID: 42089675.

    Read at: PubMed

  • Published 4/14/2026

    Streicher F, Kenney D, Caval V, Chazal M, Aicher S-M, Gracias S, Adams S, Matsuo M, Roesch F, Douam F, Jouvenet N. Type I and III interferon responses restrict infection by tick-borne orthoflaviviruses through IFI6. J Virol. 2026 May 19; 100(5):e0076025. PMID: 41979927.

    Read at: PubMed

  • Published 1/5/2026

    Subramaniam S, Napoleon MA, Lotfollahzadeh S, Kamal MH, Kurniawan H, Francis C, Elsadawi M, Wu Wong DJ, Kenney D, Douam F, Bosmann M, Whelan SA, Cabral H, Burks EJ, Zhao G, Kolachalama VB, Ravid K, Chitalia VC. Tryptophan metabolism reprogramming potentially contributes to the prothrombotic milieu in mice and humans with SARS-CoV-2. Blood Vessel Thromb Hemost. 2026 Feb; 3(1):100128. PMID: 41743170.

    Read at: PubMed

  • Published 9/29/2025

    Unali G, Douam F. Orthoflavivirus Vaccine Platforms: Current Strategies and Challenges. Vaccines (Basel). 2025 Sep 29; 13(10). PMID: 41150403.

    Read at: PubMed

View All 58 Publications:   View Full Profile in BUMC

Other Positions

  • Faculty, National Emerging Infectious Disease Lab
    Boston University
  • Graduate Medical Sciences Educator and Mentor (Primary Mentor of Graduate Students)
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Websites

Education

  • L'École Normale Supérieure de Lyon, PhD
  • Universite De Tours, BS

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