Dr. Chen attends on the Pulmonary Consult service and in the Medical Intensive Care Units at Boston Medical Center and Sturdy Memorial Hospital. She is a member of Dr. Wellington V. Cardoso’s lab.
The abnormalities of the developing respiratory system associated with retinoic acid (RA)-deficiency have been known for decades. However, the cellular and molecular events controlled by RA during lung development remain unclear. Dr. Chen’s research focuses on the various RA-dependent signaling mechanisms involved in primary lung bud formation. By using a combination of pharmacologic, genetic, and organ culture approaches, she has demonstrated the critical role of RA in controlling at least three major pathways, Tgf-beta, Wnt, and Fgf, to allow proper formation of the early lung. Currently, she’s investigating the role of retinoic acid in the differentiation of bronchial and vascular smooth muscles during lung development.
Special interests include:
-Mechanisms of primary lung bud induction
-Lung progenitor biology
-Role of retinoic acid in early lung development
-Lung injury and repair
- Courtesy Staff Privileges, Medicine, Boston Medical Center
- Albany Medical College, MD
- Johns Hopkins University, BA
- Published on 8/11/2016
Chen F, Fine A. Stem Cells in Lung Injury and Repair. Am J Pathol. 2016 Oct; 186(10):2544-50. PMID: 27524796.
- Published on 1/1/2015
Chen F, Cardoso WV. Culture of mouse embryonic foregut explants. Methods Mol Biol. 2015; 1189:163-9. PMID: 25245693.
- Published on 5/17/2010
Chen F, Cao Y, Qian J, Shao F, Niederreither K, Cardoso WV. A retinoic acid-dependent network in the foregut controls formation of the mouse lung primordium. J Clin Invest. 2010 Jun; 120(6):2040-8. PMID: 20484817.
- Published on 12/1/2009
Shi W, Chen F, Cardoso WV. Mechanisms of lung development: contribution to adult lung disease and relevance to chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2009 Dec 1; 6(7):558-63. PMID: 19934349.
- Published on 8/11/2008
Tsao PN, Chen F, Izvolsky KI, Walker J, Kukuruzinska MA, Lu J, Cardoso WV. Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung. J Biol Chem. 2008 Oct 24; 283(43):29532-44. PMID: 18694942.
- Published on 7/18/2007
Chen F, Desai TJ, Qian J, Niederreither K, Lü J, Cardoso WV. Inhibition of Tgf beta signaling by endogenous retinoic acid is essential for primary lung bud induction. Development. 2007 Aug; 134(16):2969-79. PMID: 17634193.
- Published on 1/19/2006
Desai TJ, Chen F, Lü J, Qian J, Niederreither K, Dollé P, Chambon P, Cardoso WV. Distinct roles for retinoic acid receptors alpha and beta in early lung morphogenesis. Dev Biol. 2006 Mar 1; 291(1):12-24. PMID: 16427040.
- Published on 8/26/2005
Lü J, Qian J, Chen F, Tang X, Li C, Cardoso WV. Differential expression of components of the microRNA machinery during mouse organogenesis. Biochem Biophys Res Commun. 2005 Aug 26; 334(2):319-23. PMID: 16036130.