My research interests are the neurobiological basis of learning, memory, and cognitive dysfunction in normal aging as well recovery of function after neurological insults to the brain such as stroke. These studies use multidisciplinary methods including assessment of behavioral and cognitive function, neural imaging of the brain with MRI, and analysis of neuronal function and organization with neurophysiological, neurohistochemical, neuropharmacological and neuroanatomical methods. The majority of studies utilize non-human primate models of aging, stroke, brain injury and cerebrovascular disease as well as a rat model of prenatal malnutrition.
- Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Division of Graduate Medical Sciences
- University of Rochester, PhD
- Stanford University, AB
- Published on 12/11/2017
Paspalas CD, Carlyle BC, Leslie S, Preuss TM, Crimins JL, Huttner AJ, van Dyck CH, Rosene DL, Nairn AC, Arnsten AFT. The aged rhesus macaque manifests Braak stage III/IV Alzheimer's-like pathology. Alzheimers Dement. 2017 Dec 11. PMID: 29241829.
- Published on 10/18/2017
Moore TL, Bowley B, Shultz P, Calderazzo S, Shobin E, Killiany RJ, Rosene DL, Moss MB. Chronic curcumin treatment improves spatial working memory but not recognition memory in middle-aged rhesus monkeys. Geroscience. 2017 Dec; 39(5-6):571-584. PMID: 29047012.
- Published on 8/15/2017
Mortazavi F, Romano SE, Rosene DL, Rockland KS. A Survey of White Matter Neurons at the Gyral Crowns and Sulcal Depths in the Rhesus Monkey. Front Neuroanat. 2017; 11:69. PMID: 28860975.
- Published on 2/25/2017
Shobin E, Bowley MP, Estrada LI, Heyworth NC, Orczykowski ME, Eldridge SA, Calderazzo SM, Mortazavi F, Moore TL, Rosene DL. Microglia activation and phagocytosis: relationship with aging and cognitive impairment in the rhesus monkey. Geroscience. 2017 Apr; 39(2):199-220. PMID: 28238188.
- Published on 2/16/2017
Mortazavi F, Oblak AL, Morrison WZ, Schmahmann JD, Stanley HE, Wedeen VJ, Rosene DL. Geometric Navigation of Axons in a Cerebral Pathway: Comparing dMRI with Tract Tracing and Immunohistochemistry. Cereb Cortex. 2017 Feb 16; 1-14. PMID: 28203748.
- Published on 1/12/2017
Estrada LI, Robinson AA, Amaral AC, Giannaris EL, Heyworth NC, Mortazavi F, Ngwenya LB, Roberts DE, Cabral HJ, Killiany RJ, Rosene DL. Evaluation of Long-Term Cryostorage of Brain Tissue Sections for Quantitative Histochemistry. J Histochem Cytochem. 2017 Mar; 65(3):153-171. PMID: 28080173.
- Published on 9/21/2016
Moore TL, Pessina MA, Finklestein SP, Killiany RJ, Bowley B, Benowitz L, Rosene DL. Inosine enhances recovery of grasp following cortical injury to the primary motor cortex of the rhesus monkey. Restor Neurol Neurosci. 2016 Sep 21; 34(5):827-48. PMID: 27497459.
- Published on 3/26/2016
Peter CJ, Fischer LK, Kundakovic M, Garg P, Jakovcevski M, Dincer A, Amaral AC, Ginns EI, Galdzicka M, Bryce CP, Ratner C, Waber DP, Mokler D, Medford G, Champagne FA, Rosene DL, McGaughy JA, Sharp AJ, Galler JR, Akbarian S. DNA Methylation Signatures of Early Childhood Malnutrition Associated With Impairments in Attention and Cognition. Biol Psychiatry. 2016 Nov 15; 80(10):765-774. PMID: 27184921.
- Published on 2/22/2016
Mortazavi F, Wang X, Rosene DL, Rockland KS. White Matter Neurons in Young Adult and Aged Rhesus Monkey. Front Neuroanat. 2016; 10:15. PMID: 26941613.
- Published on 7/14/2015
Ngwenya LB, Heyworth NC, Shwe Y, Moore TL, Rosene DL. Age-related changes in dentate gyrus cell numbers, neurogenesis, and associations with cognitive impairments in the rhesus monkey. Front Syst Neurosci. 2015; 9:102. PMID: 26236203.
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