Douglas L. Rosene, PhD

Professor, Anatomy & Neurobiology

Douglas Rosene
617.638.4061
700 Albany St Ctr for Adv Biomed Res

Biography

My research interests are the neurobiological basis of learning, memory, and cognitive dysfunction in normal aging as well recovery of function after neurological insults to the brain such as stroke. These studies use multidisciplinary methods including assessment of behavioral and cognitive function, neural imaging of the brain with MRI, and analysis of neuronal function and organization with neurophysiological, neurohistochemical, neuropharmacological and neuroanatomical methods. The majority of studies utilize non-human primate models of aging, stroke, brain injury and cerebrovascular disease as well as a rat model of prenatal malnutrition.

Other Positions

  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences

Education

  • University of Rochester, PhD
  • Stanford University, AB

Classes Taught

  • GMS AN 702:
  • GMS AN 810
  • GMS BN 777
  • GMS MS 703
  • GMSAN810
  • GMSBN777
  • GMSBN778
  • GMSBN779
  • GMSMS703

Publications

  • Published on 10/13/2021

    Zhang J, Buller BA, Zhang ZG, Zhang Y, Lu M, Rosene DL, Medalla M, Moore TL, Chopp M. Exosomes derived from bone marrow mesenchymal stromal cells promote remyelination and reduce neuroinflammation in the demyelinating central nervous system. Exp Neurol. 2021 Oct 13; 347:113895. PMID: 34653510.

    Read at: PubMed
  • Published on 10/9/2021

    Bottenfield KR, Bowley BGE, Pessina MA, Medalla M, Rosene DL, Moore TL. Sex differences in recovery of motor function in a rhesus monkey model of cortical injury. Biol Sex Differ. 2021 Oct 09; 12(1):54. PMID: 34627376.

    Read at: PubMed
  • Published on 10/6/2021

    Medalla M, Chang W, Ibañez S, Guillamon-Vivancos T, Nittmann M, Kapitonava A, Busch SE, Moore TL, Rosene DL, Luebke JI. Layer-specific pyramidal neuron properties underlie diverse anterior cingulate cortical motor and limbic networks. Cereb Cortex. 2021 Oct 06. PMID: 34613380.

    Read at: PubMed
  • Published on 10/1/2021

    Church NT, Weissner W, Galler JR, Amaral AC, Rosene DL, McGaughy JA, Rushmore RJ, Larrabee E, Mokler DJ. In vivo microdialysis shows differential effects of prenatal protein malnutrition and stress on norepinephrine, dopamine, and serotonin levels in rat orbital frontal cortex. Behav Neurosci. 2021 Oct; 135(5):629-641. PMID: 34582223.

    Read at: PubMed
  • Published on 7/1/2021

    Farris CW, Killiany RJ, O'Donoghue E, Koo BB, Wainford RD, Moss MB, Rosene DL, Moore TL. The relationship of age and hypertension with cognition and gray matter cerebral blood volume in a rhesus monkey model of human aging. Behav Neurosci. 2021 Oct; 135(5):680-692. PMID: 34197136.

    Read at: PubMed
  • Published on 6/1/2021

    Rushmore RJ, Bouix S, Kubicki M, Rathi Y, Rosene DL, Yeterian EH, Makris N. MRI-based Parcellation and Morphometry of the Individual Rhesus Monkey Brain: the macaque Harvard-Oxford Atlas (mHOA), a translational system referencing a standardized ontology. Brain Imaging Behav. 2021 Jun; 15(3):1589-1621. PMID: 32960419.

    Read at: PubMed
  • Published on 4/23/2021

    Clark IC, Gutiérrez-Vázquez C, Wheeler MA, Li Z, Rothhammer V, Linnerbauer M, Sanmarco LM, Guo L, Blain M, Zandee SEJ, Chao CC, Batterman KV, Schwabenland M, Lotfy P, Tejeda-Velarde A, Hewson P, Manganeli Polonio C, Shultis MW, Salem Y, Tjon EC, Fonseca-Castro PH, Borucki DM, Alves de Lima K, Plasencia A, Abate AR, Rosene DL, Hodgetts KJ, Prinz M, Antel JP, Prat A, Quintana FJ. Barcoded viral tracing of single-cell interactions in central nervous system inflammation. Science. 2021 04 23; 372(6540). PMID: 33888612.

    Read at: PubMed
  • Published on 4/1/2021

    Tsintou M, Dalamagkas K, Moore TL, Rathi Y, Kubicki M, Rosene DL, Makris N. The use of hydrogel-delivered extracellular vesicles in recovery of motor function in stroke: a testable experimental hypothesis for clinical translation including behavioral and neuroimaging assessment approaches. Neural Regen Res. 2021 Apr; 16(4):605-613. PMID: 33063708.

    Read at: PubMed
  • Published on 3/22/2021

    Blanke N, Go V, Rosene DL, Bigio IJ. Quantitative birefringence microscopy for imaging the structural integrity of CNS myelin following circumscribed cortical injury in the rhesus monkey. Neurophotonics. 2021 Jan; 8(1):015010. PMID: 33763502.

    Read at: PubMed
  • Published on 2/22/2021

    Buldyrev SV, Meng X, Reese TG, Mortazavi F, Rosene DL, Stanley HE, Wedeen VJ. Diffusion interactions between crossing fibers of the brain. Magn Reson Med. 2021 07; 86(1):429-441. PMID: 33619754.

    Read at: PubMed

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