Douglas L. Rosene, PhD

Emeritus Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

My research interests are the neurobiological basis of learning, memory, and cognitive dysfunction in normal aging as well recovery of function after neurological insults to the brain such as stroke. These studies use multidisciplinary methods including assessment of behavioral and cognitive function, neural imaging of the brain with MRI, and analysis of neuronal function and organization with neurophysiological, neurohistochemical, neuropharmacological and neuroanatomical methods. The majority of studies utilize non-human primate models of aging, stroke, brain injury and cerebrovascular disease as well as a rat model of prenatal malnutrition.

Publications

  • Published 7/20/2026

    Zhou Y, Hsiung M, Capriglione AL, Joyce MKP, Bhatt H, Mojica CA, Chang W, Tsolias A, Moore TL, Rosene DL, Luebke JI, Medalla M. Subregional and laminar specializations of pyramidal neurons in the macaque anterior cingulate cortex. J Neurosci. 2026 Jul 20. PMID: 42476911.

    Read at: PubMed

  • Published 6/15/2026

    Capen TJ, O'Donnell LJ, Zhang F, Yeterian EH, Rathi Y, Makris N, Rosene DL, Rushmore RJ. Connectional neuroanatomy of U-fibers in the rhesus monkey brain. bioRxiv. 2026 Jun 15. PMID: 42282614.

    Read at: PubMed

  • Published 12/2/2025

    Mackie EC, Cheng CH, Alibrio MN, Rutledge C, Xin H, Chopp M, McCann RP, Rosene DL, Yang Q, Zeldich E, Medalla M, Koo BB, Moore TL. Mesenchymal cell-derived extracellular vesicles ameliorate age-related deficits in working memory and in vivo MRI measures of white matter structure and function in rhesus monkeys. Geroscience. 2025 Dec 02. PMID: 41329450.

    Read at: PubMed

  • Published 11/24/2025

    Vitantonio AT, Dimovasili C, Liu Y, Ye B, Lee JR, Hartigan M, Bouchard B, Ray M, Conner B, Vaughan KL, Mattison JA, Moore TL, Zhang C, Rosene DL. Calorie Restriction Attenuates Transcriptional Aging Signatures in White Matter Oligodendrocytes and Immune Cells of the Monkey Brain. Aging Cell. 2026 Jan; 25(1):e70298. PMID: 41283828.

    Read at: PubMed

  • Published 10/28/2025

    Gray AJ, Robinson RE, Berghol SA, Rosene DL, Moore TL, Bigio IJ. Birefringence microscopy enables rapid, label-free quantification of myelin debris following induced cortical injury. Neurophotonics. 2025 Oct; 12(4):045006. PMID: 41181030.

    Read at: PubMed

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Websites

Education

  • University of Rochester, PhD
  • Stanford University, AB

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