Douglas L. Rosene, PhD
Professor, Anatomy & Neurobiology
Biography
My research interests are the neurobiological basis of learning, memory, and cognitive dysfunction in normal aging as well recovery of function after neurological insults to the brain such as stroke. These studies use multidisciplinary methods including assessment of behavioral and cognitive function, neural imaging of the brain with MRI, and analysis of neuronal function and organization with neurophysiological, neurohistochemical, neuropharmacological and neuroanatomical methods. The majority of studies utilize non-human primate models of aging, stroke, brain injury and cerebrovascular disease as well as a rat model of prenatal malnutrition.
Other Positions
- Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
Education
- University of Rochester, PhD
- Stanford University, AB
Classes Taught
- GMS AN 702:
- GMS AN 810
- GMS BN 777
- GMS MS 703
Publications
- Published on 2/8/2023
Moore TL, Medalla M, Iba Ez S, Wimmer K, Mojica CA, Killiany RJ, Moss MB, Luebke JI, Rosene DL. Neuronal properties of pyramidal cells in lateral prefrontal cortex of the aging rhesus monkey brain are associated with performance deficits on spatial working memory but not executive function. bioRxiv. 2023 Feb 08. PMID: 36798388.
Read at: PubMed - Published on 10/7/2022
Kumar AA, Yeo N, Whittaker M, Attra P, Barrick TR, Bridges LR, Dickson DW, Esiri MM, Farris CW, Graham D, Lin WL, Meijles DN, Pereira AC, Perry G, Rosene DL, Shtaya AB, Van Agtmael T, Zamboni G, Hainsworth AH. Vascular Collagen Type-IV in Hypertension and Cerebral Small Vessel Disease. Stroke. 2022 Dec; 53(12):3696-3705. PMID: 36205142.
Read at: PubMed - Published on 8/18/2022
Calderazzo S, Covert M, Alba D, Bowley BE, Pessina MA, Rosene DL, Buller B, Medalla M, Moore TL. Neural recovery after cortical injury: Effects of MSC derived extracellular vesicles on motor circuit remodeling in rhesus monkeys. IBRO Neurosci Rep. 2022 Dec; 13:243-254. PMID: 36590089.
Read at: PubMed - Published on 8/5/2022
Dimovasili C, Fair AE, Garza IR, Batterman KV, Mortazavi F, Moore TL, Rosene DL. Aging compromises oligodendrocyte precursor cell maturation and efficient remyelination in the monkey brain. Geroscience. 2023 Feb; 45(1):249-264. PMID: 35930094.
Read at: PubMed - Published on 5/14/2022
Medalla M, Chang W, Ibañez S, Guillamon-Vivancos T, Nittmann M, Kapitonava A, Busch SE, Moore TL, Rosene DL, Luebke JI. Layer-specific pyramidal neuron properties underlie diverse anterior cingulate cortical motor and limbic networks. Cereb Cortex. 2022 05 14; 32(10):2170-2196. PMID: 34613380.
Read at: PubMed - Published on 2/4/2022
Nieder C, Rosene DL, Mortazavi F, Oblak AL, Ketten DR. Morphology and unbiased stereology of the lateral superior olive in the short-beaked common dolphin, Delphinus delphis (Cetacea, Delphinidae). J Morphol. 2022 04; 283(4):446-461. PMID: 35066941.
Read at: PubMed - Published on 1/13/2022
Eldridge SA, Mortazavi F, Rice FL, Ketten DR, Wiley DN, Lyman E, Reidenberg JS, Hanke FD, DeVreese S, Strobel SM, Rosene DL. Specializations of somatosensory innervation in the skin of humpback whales (Megaptera novaeangliae). Anat Rec (Hoboken). 2022 03; 305(3):514-534. PMID: 35023618.
Read at: PubMed - Published on 11/15/2021
Uprety A, Moss MB, Rosene DL, Killiany RJ, Moore TL. Curcumin improves reversal learning in middle-aged rhesus monkeys. Behav Neurosci. 2022 Apr; 136(2):126-138. PMID: 34780208.
Read at: PubMed - Published on 10/13/2021
Zhang J, Buller BA, Zhang ZG, Zhang Y, Lu M, Rosene DL, Medalla M, Moore TL, Chopp M. Exosomes derived from bone marrow mesenchymal stromal cells promote remyelination and reduce neuroinflammation in the demyelinating central nervous system. Exp Neurol. 2022 01; 347:113895. PMID: 34653510.
Read at: PubMed - Published on 10/9/2021
Bottenfield KR, Bowley BGE, Pessina MA, Medalla M, Rosene DL, Moore TL. Sex differences in recovery of motor function in a rhesus monkey model of cortical injury. Biol Sex Differ. 2021 10 09; 12(1):54. PMID: 34627376.
Read at: PubMed
View 181 more publications: View full profile at BUMC