Darrell N. Kotton, MD

Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Darrell N. Kotton, MD is the founding director of the Center for Regenerative Medicine of Boston University and Boston Medical Center. He is a physician-scientist with attending physician duties in pulmonary and critical care medicine at Boston Medical Center and is the David C. Seldin Professor in the department of medicine and in the department of pathology and laboratory medicine at the Boston University Chobanian and Avedesian School of Medicine. Dr. Kotton is an Allen Distinguished Investigator, a Paul G. Allen Frontiers Group advised program of the Paul G. Allen Family Foundation. He is also an elected member of the American Society of Clinical Investigators and the Association of American Physicians. He leads a basic research laboratory, funded continuously by the NIH since 2004, focused on lung regeneration and stem cell biology, and he serves on the NIH’s National Heart Lung and Blood Institute’s Board of External Experts. He is the recipient of the American Thoracic Society’s “Recognition Award for Scientific Accomplishments” (2018), the AAMC inaugural national “Research Resources Sharing Award” (2017), the Alpha-1 Foundation’s “Researcher of the Year” (2013) and “Shillelagh” (2010) Awards, Boston University’s Graduate Medical Sciences Educator of the Year Award (2018), and the Robert Dawes Evans Senior Research Mentor Award from Boston University.

Expertise: Stem Cell Biology; iPS cells; Reprogramming; Gene Therapy; Lung Developmental Biology.

Publications

  • Published 8/1/2026

    Cooney AL, Lamer S, Yang P, Wegner DJ, White FV, Cole FS, Wohlford-Lenane C, Hennessey E, Bawa P, Kotton DN, Sinn PL, Wambach JA, McCray PB. Lentiviral-mediated gene complementation to rescue pathogenic ABCA3 variants. Am J Respir Cell Mol Biol. 2026 Aug 01; 74(8):1089-1102. PMID: 42089300.

    Read at: PubMed

  • Published 8/1/2026

    Ma L, Thapa BR, Le Suer JA, Tilston-Lünel A, Herriges MJ, Wang F, Bawa PS, Varelas X, Hawkins FJ, Kotton DN. Author Correction: Life-long functional regeneration of in vivo airway epithelium by the engraftment of airway basal stem cells. Nat Protoc. 2026 Aug; 21(8):3814. PMID: 40164751.

    Read at: PubMed

  • Published 7/14/2026

    Pek NM, Thorner K, Guo M, Dennison H, Rajaguru T, Stan G, Kishimoto K, Rottier RJ, Kotton DN, Zorn AM, Gu M. Vessel Organoids Reveal FOXF1 Variant-Specific Regulation of Mesoderm and Capillary Development. bioRxiv. 2026 Jul 14. PMID: 42523355.

    Read at: PubMed

  • Published 6/29/2026

    Xu L, Chen KH, Dash B, Yao B, Li R, Wang X, Zhou Z, Yu V, Salamon R, Bawa PS, Guo M, Borok Z, Kotton DN, Eickelberg O, Bueno M, Sun X. Mesothelial Plasticity Specifies a Pleural Immune Circuit that Orchestrates Lung Regeneration. bioRxiv. 2026 Jun 29. PMID: 42427767.

    Read at: PubMed

  • Published 6/1/2026

    Dobie AC, Win W, Kotton DN, Monaghan JR. Toward human lung regeneration: gaining insights from the axolotl salamander Ambystoma mexicanum. Am J Respir Cell Mol Biol. 2026 Jun 01; 74(6):718-726. PMID: 41086376.

    Read at: PubMed

View All 197 Publications:   View Full Profile in BUMC

Other Positions

  • Director, Center for Regenerative Medicine
    Boston University
  • Professor, Pathology & Laboratory Medicine
    Boston University Chobanian & Avedisian School of Medicine
  • Investigator
    Framingham Heart Study
  • Member, Pulmonary Center
    Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research
    Boston University
  • Member, Genome Science Institute
    Boston University
  • Graduate Medical Sciences Educator and Mentor (Primary Mentor of Graduate Students)
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Websites

Education

  • Washington University School of Medicine, MD
  • University of Pennsylvania, BA

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