Darrell Nelson Kotton, MD

Professor, Medicine

Darrell Kotton
617.414.2969
670 Albany St Biosquare III

Biography

Expertise includes: Stem Cell Biology; iPS cells; Reprogramming; Gene Therapy; Lung Developmental Biology.

Other Positions

  • Director, Center for Regenerative Medicine, Boston University School of Medicine
  • Professor, Pathology & Laboratory Medicine, Boston University School of Medicine
  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences
  • Active Staff Privileges, Pulmonary, Allergy, Sleep & Critical Care Medicine, Medicine, Boston Medical Center

Education

  • Washington University School of Medicine, MD
  • University of Pennsylvania, BA

Publications

  • Published on 8/15/2019

    Kwong G, Marquez HA, Yang C, Wong JY, Kotton DN. Generation of a Purified iPSC-Derived Smooth Muscle-like Population for Cell Sheet Engineering. Stem Cell Reports. 2019 Sep 10; 13(3):499-514. PMID: 31422908.

    Read at: PubMed
  • Published on 2/22/2019

    Reeves EP, Dunlea DM, McQuillan K, O'Dwyer CA, Carroll TP, Saldova R, Akepati PR, Wormald MR, McElvaney OJ, Shutchaidat V, Henry M, Meleady P, Keenan J, Liberti DC, Kotton DN, Rudd PM, Wilson AA, McElvaney NG. Circulating Truncated Alpha-1 Antitrypsin Glycoprotein in Patient Plasma Retains Anti-Inflammatory Capacity. J Immunol. 2019 Apr 15; 202(8):2240-2253. PMID: 30796179.

    Read at: PubMed
  • Published on 10/15/2018

    Reeves EP, O'Dwyer CA, Dunlea DM, Wormald MR, Hawkins P, Alfares M, Kotton DN, Rowe SM, Wilson AA, McElvaney NG. Ataluren, a New Therapeutic for Alpha-1 Antitrypsin-Deficient Individuals with Nonsense Mutations. Am J Respir Crit Care Med. 2018 10 15; 198(8):1099-1102. PMID: 30011228.

    Read at: PubMed
  • Published on 9/10/2018

    Hawkins FJ, Kotton DN. Pulmonary Ionocytes Challenge the Paradigm in Cystic Fibrosis. Trends Pharmacol Sci. 2018 10; 39(10):852-854. PMID: 30213439.

    Read at: PubMed
  • Published on 5/4/2018

    McCauley KB, Hawkins F, Kotton DN. Derivation of Epithelial-Only Airway Organoids from Human Pluripotent Stem Cells. Curr Protoc Stem Cell Biol. 2018 05; 45(1):e51. PMID: 30040246.

    Read at: PubMed
  • Published on 4/12/2018

    McCauley KB, Alysandratos KD, Jacob A, Hawkins F, Caballero IS, Vedaie M, Yang W, Slovik KJ, Morley M, Carraro G, Kook S, Guttentag SH, Stripp BR, Morrisey EE, Kotton DN. Single-Cell Transcriptomic Profiling of Pluripotent Stem Cell-Derived SCGB3A2+ Airway Epithelium. Stem Cell Reports. 2018 05 08; 10(5):1579-1595. PMID: 29657097.

    Read at: PubMed
  • Published on 2/5/2018

    Kotton DN. Claudin-18: unexpected regulator of lung alveolar epithelial cell proliferation. J Clin Invest. 2018 03 01; 128(3):903-905. PMID: 29400691.

    Read at: PubMed
  • Published on 9/28/2017

    Jacob A, Morley M, Hawkins F, McCauley KB, Jean JC, Heins H, Na CL, Weaver TE, Vedaie M, Hurley K, Hinds A, Russo SJ, Kook S, Zacharias W, Ochs M, Traber K, Quinton LJ, Crane A, Davis BR, White FV, Wambach J, Whitsett JA, Cole FS, Morrisey EE, Guttentag SH, Beers MF, Kotton DN. Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells. Cell Stem Cell. 2017 Oct 05; 21(4):472-488.e10. PMID: 28965766.

    Read at: PubMed
  • Published on 9/25/2017

    Serra M, Alysandratos KD, Hawkins F, McCauley KB, Jacob A, Choi J, Caballero IS, Vedaie M, Kurmann AA, Ikonomou L, Hollenberg AN, Shannon JM, Kotton DN. Pluripotent stem cell differentiation reveals distinct developmental pathways regulating lung- versus thyroid-lineage specification. Development. 2017 11 01; 144(21):3879-3893. PMID: 28947536.

    Read at: PubMed
  • Published on 9/19/2017

    Luo J, Qin L, Kural MH, Schwan J, Li X, Bartulos O, Cong XQ, Ren Y, Gui L, Li G, Ellis MW, Li P, Kotton DN, Dardik A, Pober JS, Tellides G, Rolle M, Campbell S, Hawley RJ, Sachs DH, Niklason LE, Qyang Y. Vascular smooth muscle cells derived from inbred swine induced pluripotent stem cells for vascular tissue engineering. Biomaterials. 2017 Dec; 147:116-132. PMID: 28942128.

    Read at: PubMed

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