Darrell Nelson Kotton, MD

Professor, Pathology & Laboratory Medicine

Darrell Kotton
617.414.2969
670 Albany St Biosquare III

Biography

Expertise includes: Stem Cell Biology; iPS cells; Reprogramming; Gene Therapy; Lung Developmental Biology.

Other Positions

  • Professor, Pulmonary, Allergy, Sleep & Critical Care Medicine, Medicine, Boston University School of Medicine
  • Director, Center for Regenerative Medicine, Boston University School of Medicine
  • Investigator, Framingham Heart Study
  • Member, Pulmonary Center, Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences
  • Member, Genome Science Institute, Boston University

Education

  • Washington University School of Medicine, MD
  • University of Pennsylvania, BA

Publications

  • Published on 6/17/2020

    Cohen Y, Shen J, Semu D, Leman DP, Liberti WA, Perkins LN, Liberti DC, Kotton DN, Gardner TJ. Hidden neural states underlie canary song syntax. Nature. 2020 Jun 17. PMID: 32555461.

    Read at: PubMed
  • Published on 4/2/2020

    Basil MC, Katzen J, Engler AE, Guo M, Herriges MJ, Kathiriya JJ, Windmueller R, Ysasi AB, Zacharias WJ, Chapman HA, Kotton DN, Rock JR, Snoeck HW, Vunjak-Novakovic G, Whitsett JA, Morrisey EE. The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future. Cell Stem Cell. 2020 Apr 02; 26(4):482-502. PMID: 32243808.

    Read at: PubMed
  • Published on 1/31/2020

    Ikonomou L, Herriges MJ, Lewandowski SL, Marsland R, Villacorta-Martin C, Caballero IS, Frank DB, Sanghrajka RM, Dame K, Kandula MM, Hicks-Berthet J, Lawton ML, Christodoulou C, Fabian AJ, Kolaczyk E, Varelas X, Morrisey EE, Shannon JM, Mehta P, Kotton DN. The in vivo genetic program of murine primordial lung epithelial progenitors. Nat Commun. 2020 01 31; 11(1):635. PMID: 32005814.

    Read at: PubMed
  • Published on 1/30/2020

    Hurley K, Ding J, Villacorta-Martin C, Herriges MJ, Jacob A, Vedaie M, Alysandratos KD, Sun YL, Lin C, Werder RB, Huang J, Wilson AA, Mithal A, Mostoslavsky G, Oglesby I, Caballero IS, Guttentag SH, Ahangari F, Kaminski N, Rodriguez-Fraticelli A, Camargo F, Bar-Joseph Z, Kotton DN. Reconstructed Single-Cell Fate Trajectories Define Lineage Plasticity Windows during Differentiation of Human PSC-Derived Distal Lung Progenitors. Cell Stem Cell. 2020 Apr 02; 26(4):593-608.e8. PMID: 32004478.

    Read at: PubMed
  • Published on 1/10/2020

    Mithal A, Capilla A, Heinze D, Berical A, Villacorta-Martin C, Vedaie M, Jacob A, Abo K, Szymaniak A, Peasley M, Stuffer A, Mahoney J, Kotton DN, Hawkins F, Mostoslavsky G. Generation of mesenchyme free intestinal organoids from human induced pluripotent stem cells. Nat Commun. 2020 01 10; 11(1):215. PMID: 31924806.

    Read at: PubMed
  • Published on 11/15/2019

    Jacob A, Vedaie M, Roberts DA, Thomas DC, Villacorta-Martin C, Alysandratos KD, Hawkins F, Kotton DN. Derivation of self-renewing lung alveolar epithelial type II cells from human pluripotent stem cells. Nat Protoc. 2019 12; 14(12):3303-3332. PMID: 31732721.

    Read at: PubMed
  • Published on 8/15/2019

    Kwong G, Marquez HA, Yang C, Wong JY, Kotton DN. Generation of a Purified iPSC-Derived Smooth Muscle-like Population for Cell Sheet Engineering. Stem Cell Reports. 2019 09 10; 13(3):499-514. PMID: 31422908.

    Read at: PubMed
  • Published on 2/22/2019

    Reeves EP, Dunlea DM, McQuillan K, O'Dwyer CA, Carroll TP, Saldova R, Akepati PR, Wormald MR, McElvaney OJ, Shutchaidat V, Henry M, Meleady P, Keenan J, Liberti DC, Kotton DN, Rudd PM, Wilson AA, McElvaney NG. Circulating Truncated Alpha-1 Antitrypsin Glycoprotein in Patient Plasma Retains Anti-Inflammatory Capacity. J Immunol. 2019 04 15; 202(8):2240-2253. PMID: 30796179.

    Read at: PubMed
  • Published on 10/15/2018

    Reeves EP, O'Dwyer CA, Dunlea DM, Wormald MR, Hawkins P, Alfares M, Kotton DN, Rowe SM, Wilson AA, McElvaney NG. Ataluren, a New Therapeutic for Alpha-1 Antitrypsin-Deficient Individuals with Nonsense Mutations. Am J Respir Crit Care Med. 2018 10 15; 198(8):1099-1102. PMID: 30011228.

    Read at: PubMed
  • Published on 9/10/2018

    Hawkins FJ, Kotton DN. Pulmonary Ionocytes Challenge the Paradigm in Cystic Fibrosis. Trends Pharmacol Sci. 2018 10; 39(10):852-854. PMID: 30213439.

    Read at: PubMed

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